Background: Research has shown the positive connections between physical activity and health, and physical education has been shown to influence the motivation to participate in physical activities. Student-centred pedagogical models encouraging active learning may be capable of bringing about changes in girls’ physical activity. Objective: The aim of the study was to investigate whether a hybrid pedagogical model could make a difference to adolescent girls’ in-class physical activity levels. Design, setting and method: Sixty-six students aged 13–17 years participated in the study from two Year 9 and two Year 11 classes in three different high schools. All classes experienced the same 12-session hybrid sports education-tactical games learning unit. To objectively measure students’ physical activity, participants wore accelerometers. Results and conclusion: The overall results showed that students spent 39.74% of the class in moderate-to-vigorous physical activity (MVPA), but girls showed statistically significantly lower scores. While in the role of judge/referee (27.34% of the class), students showed significantly higher levels of sedentary physical activity. Finally, year 11 students showed higher MVPA than Year 9 students. In conclusion, hybrid pedagogical models, per se, may not help girls achieve MVPA scores similar to those of boys. Teachers need to identify the barriers and make necessary changes to achieve this goal. Some ideas for doing so are discussed in the paper.