Appropriate Use of Antibiotics for the Management of Respiratory Tract Infections

Abstract

Lower respiratory tract infections (LRTIs) and Upper respiratory tract infections (URTIs) cause high morbidity and mortality worldwide. Lower respiratory tract infections are generally more serious than upper infections. Antibiotics are often inappropriately prescribed for patients with RTI. Inappropriate utilization of antibiotics specifically the broad spectrum in respiratory tract infection results in resistance to antibiotics. The common use of antibiotics is the prime reason for the spread of drug resistant bacterial strains which not only results in cost treatment but high rate of morbidity and mortality due to undesired adverse effect of the drug. Literature survey was performed using PubMed, Science Direct, and Web of Science search engines. One hundred forty-five papers were retrieved, and more than 100 were included in this review. This article describes the overview and diagnosis of respiratory tract infections and plethora of antibiotics has been used in the management of RTIs.

Integrative analyses identify opportunistic pathogens of patients with lower respiratory tract infections based on metagenomic next-generation sequencing

“…Lower respiratory tract infections (LRTIs) are one of the predominant causes of morbidity and mortality among all patient populations worldwide [ 1 ]. The respiratory system harbors a myriad of bacteria; consequently, bacterial dysbiosis can trigger an escalation in colonization by opportunistic pathogens, which deems the determination of causative pathogens challenging [ 2 ].…”