Appropriateness of glycopeptide use in a hospital in Italy

Bianco, Aida; Rizza, Paolo; Scaramuzza, Gaetano; Pavia, Maria

doi:10.1016/j.ijantimicag.2005.10.004

Cited by 6 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with figures from other hospitals, where conformance to guidelines was found to be between 24% and 80% [16,17]. Culture and sensitivity tests were found to be the main guide in prescribing vancomycin for treatment as recommended by the HICPAC [4].…”

Section: Discussionsupporting

confidence: 87%

“…Among these cases were patients requiring renal replacement therapy such as hemodialysis and peritoneal dialysis. Vancomycin is recommended for treatment of patients allergic to beta-lactam-sensitive Gram-positive bacteria in renal impairment [16]. However, during the study, only 7.6% of these patients were allergic to beta-lactam antibiotics.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Appropriate vancomycin use in a Malaysian tertiary hospital based on current HICPAC recommendations

Islahudin

Ong

2014

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Antibiotic resistance is a rapidly emerging problem. A major concern is methicillin-resistant Staphylococcus aureus (MRSA), especially in developing countries where cost-effectiveness is imperative. Restriction of vancomycin usage is necessary to reduce the emergence of vancomycin-resistant organisms. The aim of this study was to look into the appropriate use of vancomycin based on the Healthcare Infection Control Practices Advisory Committee (HICPAC) guidelines and to investigate serum levels of vancomycin. Methodology: The study was performed retrospectively. Medical records of patients treated with vancomycin for the past year were identified and selected. Results: Overall, 118 patients were treated with vancomycin. Appropriate use of vancomycin was significantly higher than inappropriate use (p = 0.001). Approximately 85% (n = 100) of patients were given vancomycin for treatment, whereas the rest were given it for prophylaxis. Appropriate use of vancomycin was observed in 67% (n = 79) of patients. However, there was still a high rate of inappropriate vancomycin use for prophylaxis and treatment (n = 39, 33.1%). The most common reason for inappropriate use was non-neutropenic and non-line related sepsis (n = 36, 30.8%). Therapeutic drug monitoring of vancomycin was performed in 79 patients (67%). Most patients (n = 53, 67%) demonstrated sub-therapeutic levels during the first measurement. There was no significant difference between trough levels achieved with a higher (> 15 mg/kg) versus a lower dose (< 15 mg/kg). Conclusions: This study demonstrates that there was still a high level of inappropriate vancomycin use, which could potentially contribute to vancomycin resistance.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Appropriate vancomycin use in a Malaysian tertiary hospital based on current HICPAC recommendations

Islahudin

Ong

2014

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“… 39 Therefore, antimicrobial policies to promote better use of these drugs should be implemented in primary care as well as in the hospital setting where 30%–50% of antibiotics prescribed are unnecessary 40 and up to the 90% of last-line antibiotics are inappropriately prescribed. 41 …”

Section: Discussionmentioning

confidence: 99%

Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners

Bianco¹,

Papadopoli²,

Mascaro³

et al. 2018

IDR

Self Cite

View full text Add to dashboard Cite

PurposeThe overuse, misuse, and underuse of antimicrobial agents often lead to the spread of antibiotic-resistant microorganisms. The aim of our study was to describe the pattern of antibiotic prescriptions for acute respiratory tract infections (RTIs) among the adult population and the factors associated with antibiotic prescribing.Patients and methodsThe study involved patients who visited a general practitioner with suspected acute RTI. Patients with diagnosis of acute sinusitis, acute pharyngitis, acute bronchitis, and influenza were included in the study. We evaluated the presence of an indication for antibiotic therapy for selected diseases according to international guidelines. The appropriateness of any prescribed molecule was also evaluated.ResultsA total of 1,979 cases of acute RTIs were included: 1,196 (60.4%) pharyngitis, 359 (18.2%) bronchitis, 234 (11.8%) influenza, and 190 (9.6%) sinusitis. An antibiotic prescription was given in 67.3% of the consultations and was not indicated by the guidelines in 66.5% of the total RTIs. Macrolides were the most frequently prescribed antibiotics accounting for 32.5% of all those prescribed, followed by amoxicillin with clavulanic acid (31.1%) and fluoroquinolones (14.2%). The highest overprescription was associated with pharyngitis (65.9%) and the lowest with influenza (4.9%). A throat swab was performed only in 11 of all the patients with a diagnosis of acute pharyngitis.ConclusionThe present study showed a very high frequency of nonevidence-based prescription of antibiotics at the primary care level. Future improvement programs should focus on development of evidence-based guidelines, access to postgraduate training, and better availability of diagnostic tools.

show abstract

“…10 However, the variables that were associated with IAP in our study differed from those identified in other studies -such as increased patient age, HA infection, prophylaxis and fluoroquinolone usage. 5,11,12 This highlights the need for hospitals to conduct their own audits to identify site-specific factors associated with IAP. Such information could then be used to tailor their antimicrobial stewardship interventions.…”

Section: Brief Communicationmentioning

confidence: 99%

Point‐prevalence study of inappropriate antibiotic use at a tertiary Australian hospital

Ingram¹,

Seet²,

Budgeon

et al. 2012

Internal Medicine Journal

View full text Add to dashboard Cite

A point‐prevalence study at a tertiary Australian hospital found 199 of 462 inpatients (43%) to be receiving antibiotic therapy. Forty‐seven per cent of antibiotic use was discordant with guidelines or microbiological results and hence considered inappropriate. Risk factors for inappropriate antibiotic prescribing included bone/joint infections, the absence of infection, creatinine level >120 µmol/L, carbapenem or macrolide use and being under the care of the aged care/rehabilitation team. In the setting of finite antimicrobial stewardship resources, identification of local determinants for inappropriate antibiotic use may enable more targeted interventions.

show abstract

Appropriateness of glycopeptide use in a hospital in Italy

Cited by 6 publications

References 30 publications

Appropriate vancomycin use in a Malaysian tertiary hospital based on current HICPAC recommendations

Appropriate vancomycin use in a Malaysian tertiary hospital based on current HICPAC recommendations

Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners

Point‐prevalence study of inappropriate antibiotic use at a tertiary Australian hospital

Contact Info

Product

Resources

About