Appropriateness of perioperative blood transfusion in patients undergoing cancer surgery: A prospective single-centre study

Ranganathan, Priya; Ahmed, Sarfaraz; Kulkarni, Atul P; Divatia, Jigeeshu Vasishtha

doi:10.4103/0019-5049.98763

Cited by 9 publications

(9 citation statements)

References 13 publications

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“…In our study, surgical procedures were performed by mostly use of regional anaesthesia in both the groups. According to Malhotra et al, performed by regional anaesthesia [21] . In the study, the primary efficacy outcome (total VTE and allcause mortality) occurred in 13.0% of patients in the Rivaroxaban group and 17.3% of patients in the enoxaparin group.…”

Section: Discussionmentioning

confidence: 99%

Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty

Ligu¹,

Jini²

2020

Int. J. Orthop. Sci.

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Background: Introduction: Total hip arthroplasty (THA) is a successful surgical procedure for reducing pain and improving physical function in osteoarthritis. It is one of the most effective orthopaedic procedures. Material and methods: Patients were eligible for the study if they were aged 18 years or older and were scheduled for total hip arthroplasty. Patients were ineligible if they were scheduled to undergo staged, bilateral hip arthroplasty were pregnant or breastfeeding, had active bleeding or a high risk of bleeding, or any disorder contraindicating the use of Rivaroxaban/enoxaparin that might necessitate enoxaparin dose adjustment. Results: Of the 52 patients enrolled in study, 52 patients were randomized to receive either Rivaroxaban (n=26) or enoxaparin (n=26). The baseline demographic characteristics of the two randomized treatment groups are well balanced as described in Table 1. The surgical characteristics are described in Table 2. Conclusion: Rivaroxaban, given as a once-daily 10 mg fixed dose 6-8 h postoperatively, is the first new oral anticoagulant to significantly reduce the incidence of venous thromboembolism after total knee arthroplasty, compared with enoxaparin 30 mg twice daily, starting 12-24 h postoperatively, without a significant difference in the risk of major or clinically relevant bleeding.

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Section: Discussionmentioning

confidence: 99%

Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty

Ligu¹,

Jini²

2020

Int. J. Orthop. Sci.

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“…These values include factors, such as hemoglobin levels, total blood loss, and operative time, which are traditionally believed to be predictive for administering a transfusion. 10, 11, 12, 13 …”

Section: Discussionmentioning

confidence: 99%

Restrictive blood transfusion protocol in malignant upper gastrointestinal and pancreatic resections patients reduces blood transfusions with no increase in patient morbidity

Wehry

Agle

Philips

et al. 2015

The American Journal of Surgery

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Background The purpose of this study was to determine the impact of a restrictive blood transfusion protocol on the number of transfusions performed and the related effect on patient morbidity. Methods A cohort study was performed using our prospective database with information from 01/01/2000–06/01/2013. The restrictive blood transfusion protocol was implemented in 9/2011, so this date served as the separation point for the date of operation criteria. Results For the study, 415 patients undergoing operation for an abdominal malignancy were reviewed. Following the restrictive blood transfusion protocol the percentage of patients that received blood dropped from 35.6% to 28.3%. The percentage of patients that experienced perioperative complication was significantly higher in transfused patients compared to those that did not receive blood(p=0.0001). There was no statistical significance observed between the four groups for the length of stay at the hospital following their procedure. Conclusion The restrictive blood transfusion protocol resulted in a reduction of the percentage of patients transfused, and there was no evidence to suggest that it negatively impacted the outcomes of patients in this group.

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“…However, many centres in India still do cardiac surgeries using a conventional CPB with limited resources and there is a considerable variation in blood transfusion practice in different medical centres in India. One report from Western India indicates over-transfusion in more than 50% of cases,[ 3 ] whereas a South Indian study reveals appropriate blood transfusion in 90% of patients from their study cohort,[ 4 ] which implies differences in perioperative practice patterns as well as possible inappropriate use and therefore, current transfusion practices may require re-evaluation.…”

Section: Introductionmentioning

confidence: 99%

Blood transfusion practices in cardiac anaesthesia

Mangu¹,

Samantaray²,

Anakapalli³

2014

Indian J Anaesth

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The primary reasons for blood transfusion in cardiac surgery are to correct anaemia and to improve tissue oxygen delivery. However, there is a considerable debate regarding the actual transfusion trigger at which the benefits of transfusion overweight the risk. The association between extreme haemodilution, transfusion and adverse outcome after cardio pulmonary bypass (CPB) is not clear and the current available literature is not sufficient to provide a strong recommendation regarding the safe haematocrit range during CPB. There is no quality evidence to support use of fresh red blood cell except during massive transfusion or exchange transfusion in neonate. Overall concern regarding the safety of allogeneic blood transfusion resulted in the search for autologous blood transfusion and perioperative blood salvage. The aim of this review is to provide cardiac surgery specific clinically useful guidelines pertaining to transfusion triggers, optimal haemodilution during CPB, autologous blood transfusion and role of perioperative blood salvage based on available evidence.

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Appropriateness of perioperative blood transfusion in patients undergoing cancer surgery: A prospective single-centre study

Cited by 9 publications

References 13 publications

Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty

Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty

Restrictive blood transfusion protocol in malignant upper gastrointestinal and pancreatic resections patients reduces blood transfusions with no increase in patient morbidity

Blood transfusion practices in cardiac anaesthesia

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