Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood

Yeragani, Vikram K.; Pohl, Robert; Mallavarapu, Mallika; Balon, Richard

doi:10.1034/j.1399-5618.2003.00012.x

Cited by 50 publications

(31 citation statements)

References 34 publications

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“…11, 15 In contrast to chronically stressed mice, 11, 37 fluoxetine may induce some behavioral effects independent of neurogenesis and fail to alter neurogenesis in unstressed BALB/c mice. 58, 60 Considering that antidepressants are mainly devoid of mood-changing effects in non-depressed healthy humans 61, 62, 63 and that fluoxetine effects on behavior and large-scale gene expression greatly differ depending if the mice are under control or UCMS conditions, 33 paradigms elaborated in ‘non-depressed' mice may engage different neurobiological mechanisms that are perhaps irrelevant to clinical remission. Rather, it is likely that relevant antidepressant effects are conditional on the presence of a disorder-related neuropathology.…”

Section: Discussionmentioning

confidence: 99%

Antidepressants recruit new neurons to improve stress response regulation

et al. 2011

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Recent research suggests an involvement of hippocampal neurogenesis in behavioral effects of antidepressants. However, the precise mechanisms through which newborn granule neurons might influence the antidepressant response remain elusive. Here, we demonstrate that unpredictable chronic mild stress in mice not only reduces hippocampal neurogenesis, but also dampens the relationship between hippocampus and the main stress hormone system, the hypothalamo-pituitary-adrenal (HPA) axis. Moreover, this relationship is restored by treatment with the antidepressant fluoxetine, in a neurogenesis-dependent manner. Specifically, chronic stress severely impairs HPA axis activity, the ability of hippocampus to modulate downstream brain areas involved in the stress response, the sensitivity of the hippocampal granule cell network to novelty/glucocorticoid effects and the hippocampus-dependent negative feedback of the HPA axis. Remarkably, we revealed that, although ablation of hippocampal neurogenesis alone does not impair HPA axis activity, the ability of fluoxetine to restore hippocampal regulation of the HPA axis under chronic stress conditions, occurs only in the presence of an intact neurogenic niche. These findings provide a mechanistic framework for understanding how adult-generated new neurons influence the response to antidepressants. We suggest that newly generated neurons may facilitate stress integration and that, during chronic stress or depression, enhancing neurogenesis enables a dysfunctional hippocampus to restore the central control on stress response systems, then allowing recovery.

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Section: Discussionmentioning

confidence: 99%

Antidepressants recruit new neurons to improve stress response regulation

et al. 2011

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“…For example, nonlinear analysis of the temporal structure of the variability has recently been used to study heart rate irregularities, sudden cardiac death syndrome, blood pressure control, brain ischemia, epileptic seizures, and several other conditions. 1,10,12,13,17,41 Such research has allowed for a better understanding of the complexity of these pathologies and eventually led to the development of better prognostic and diagnostic tools in other areas (i.e., cardiology, neurology). Thus, it is fair to assume that nonlinear analysis of the sway variability could allow insight into the complex strategies used to control movement and posture informing clinical practice with respect to movement related disorders.…”

Section: Introductionmentioning

confidence: 99%

Locomotor Sensory Organization Test: How Sensory Conflict Affects the Temporal Structure of Sway Variability During Gait

et al. 2015

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When maintaining postural stability temporally under increased sensory conflict, a more rigid response is used where the available degrees of freedom are essentially frozen. The current study investigated if such a strategy is also utilized during more dynamic situations of postural control as is the case with walking. This study attempted to answer this question by using the Locomotor Sensory Organization Test (LSOT). This apparatus incorporates SOT inspired perturbations of the visual and the somatosensory system. Ten healthy young adults performed the six conditions of the traditional SOT and the corresponding six conditions on the LSOT. The temporal structure of sway variability was evaluated from all conditions. The results showed that in the anterior posterior direction somatosensory input is crucial for postural control for both walking and standing; visual input also had an effect but was not as prominent as the somatosensory input. In the medial lateral direction and with respect to walking, visual input has a much larger effect than somatosensory input. This is possibly due to the added contributions by peripheral vision during walking; in standing such contributions may not be as significant for postural control. In sum, as sensory conflict increases more rigid and regular sway patterns are found during standing confirming the previous results presented in the literature, however the opposite was the case with walking where more exploratory and adaptive movement patterns are present.

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“…For instance, ApEn has been employed in clinical cardiovascular studies [12][13][14] and irregularity of EEG signals under general anesthesia [15,16]. It is referred to as a measure of the complexity of the sequence and statistical quantitative rules [17], and its computation is according to Eq.…”

Section: Approximate Entropymentioning

confidence: 99%

A critical care monitoring system for depth of anaesthesia analysis based on entropy analysis and physiological information database

Wei

Fan

et al. 2014

Australas Phys Eng Sci Med

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Diagnosis of depth of anaesthesia (DoA) plays an important role in treatment and drug usage in the operating theatre and intensive care unit. With the flourishing development of analysis methods and monitoring devices for DoA, a small amount of physiological data had been stored and shared for further researches. In this paper, a critical care monitoring (CCM) system for DoA monitoring and analysis was designed and developed, which includes two main components: a physiologic information database (PID) and a DoA analysis subsystem. The PID, including biologic data and clinical information was constructed through a browser and server model so as to provide a safe and open platform for storage, sharing and further study of clinical anaesthesia information. In the analysis of DoA, according to our previous studies on approximate entropy, sample entropy (SampEn) and multi-scale entropy (MSE), the SampEn and MSE were integrated into the subsystem for indicating the state of patients underwent surgeries in real time because of their stability. Therefore, this CCM system not only supplies the original biological data and information collected from the operating room, but also shares our studies for improvement and innovation in the research of DoA.

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Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood

Cited by 50 publications

References 34 publications

Antidepressants recruit new neurons to improve stress response regulation

Antidepressants recruit new neurons to improve stress response regulation

Locomotor Sensory Organization Test: How Sensory Conflict Affects the Temporal Structure of Sway Variability During Gait

A critical care monitoring system for depth of anaesthesia analysis based on entropy analysis and physiological information database

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