Immune cells have remarkable properties. They are able to migrate long distances, cross dense cell barriers and use a wide range of tools to identify and fight foreign materials in our body. In this context, neutrophil extracellular trap formation (NETosis), as their latest tool and a new type of cell death, has received much attention in the last years. During NETosis, leukocytes, such as neutrophilic granulocytes (neutrophils), undergo massive morphological changes leading to intracellular chromatin decondensation, membrane disruption and a final release of their nuclear content in the form of neutrophil extracellular traps (NETs). Even though many studies tried to elucidate these unique alterations, the general course of NETosis is still poorly understood.