Apraxia of Eyelid Closure Complicating Right Parietal Infarction

Hamano, Tadanori; Kimura, Seigo; Miyao, Shinichi; Teramoto, Jun

doi:10.1159/000052107

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…Fourth, lateralization could be found beyond the eloquent areas of language and motor networks. Lower FA, AD, and greater RD in the left-hemispheric inferior parietal cortex and the temporo-parieto-occipital junction could correspond to specialization of the parietal cortex in higher-order integrative functions that was observed in imaging and stimulation studies (8, 53), while ischemic lesions affecting right inferior parietal cortices have been linked with neglect and apraxia (54, 55). Strikingly, one would expect greater AD and RD, in particular when considering the specialization, in the right hemisphere as these could represent greater neuronal count and dendritic arborization or interneuronal density in the specialized area.…”

Section: Discussionmentioning

confidence: 81%

Cortical microstructure and hemispheric specialization – a diffusion-imaging analysis in younger and older adults

Wróbel,

Braaß,

Frey

et al. 2023

Preprint

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Characterizing cortical plasticity becomes increasingly important for identifying compensatory mechanisms and structural reserve in the aging population. While cortical thickness (CT) largely contributed to systems neuroscience, it incompletely informs about the underlying neuroplastic pathophysiology. In turn, microstructural characteristics may correspond to atrophy mechanisms in a more sensitive way, indicating a potentially necessary paradigm shift in neuroimaging. Fractional anisotropy (FA), a diffusion tensor imaging (DTI) measure, is inversely related to cortical histologic complexity. Axial (AD) and radial diffusivity (RD) are assumed to be linked to density of structures oriented perpendicular and parallel to cortical surface respectively. We hypothesized (1) that cortical DTI will reveal microstructural correlates for hemispheric specialization, particularly in the language and motor systems and (2) that lateralization of cortical DTI parameters will show an age effect, paralleling age-related changes in activation, especially in the prefrontal cortex. We re-analyzed data of healthy younger and older adult participants (n=91). DTI measures and CT were extracted from Destrieux atlas regions. Diffusion measures showed lateralization in specialized motor, language, visual, auditory, and inferior parietal cortices. Age-dependent increased lateralization was observed for DTI measures in the prefrontal, angular, superior temporal, and lateral occipital cortex. CT did not show any age-dependent alterations in lateralization. Our observations argue that cortical DTI is able to capture correlates of microstructural properties associated with functional specialization, resembling findings from histology. Age effects on diffusion measures in the integrative prefrontal and parietal areas may shed novel light on the atrophy-related plasticity in healthy aging.Significance statementCortical thickness significantly contributed to systems neuroscience research related to cortical neuroplasticity. However, regarding the underlying cortical microstructure it remains an unspecific measure. With a strong lateralization in diffusion measures but not in thickness in specialized areas we demonstrate that cortical diffusion MRI is suitable to grasp microstructural features linked to specialization already described in histology literature. The findings in the lateralization of prefrontal and parietal cortical features may reflect age-related dynamic in cerebral activation. These results indicate the great potential of cortical diffusion tensor imaging in neuroscience and may even emphasize a necessary paradigm shift from the assessment of cortical macrostructure towards cortical microstructure for a better understanding of neuroplasticity and structure-function relationships in health and disease.

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Section: Discussionmentioning

confidence: 81%

Cortical microstructure and hemispheric specialization – a diffusion-imaging analysis in younger and older adults

Wróbel,

Braaß,

Frey

et al. 2023

Preprint

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“…Activation of the oculomotor cortex has been associated with voluntary eyelid closure and lesions in right frontal and parietal lobes with eyelid closure apraxia. 1,2 AUTHOR CONTRIBUTIONS…”

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confidence: 99%

Teaching Video Neuro Images : Apraxia of eyelid closure following right hemispheric infarction

2017

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A 56-year-old man presented following a right middle cerebral artery territory infarction (figure). In addition to left hemiparesis and neglect, he was unable to close his left eye on command (video at Neurology.org), though he was able to blink spontaneously and keep his eyes closed during sleep. He could maintain closure of both eyes once manually closed. Apraxia of eyelid closure is distinguished clinically from eyelid closure weakness by ability to blink reflexively and maintain eyelid closure. Activation of the oculomotor cortex has been associated with voluntary eyelid closure and lesions in right frontal and parietal lobes with eyelid closure apraxia.

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Blepharospasm

Bhatti

2023

Reference Module in Neuroscience and Biobehavioral Psychology

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Apraxia of Eyelid Closure Complicating Right Parietal Infarction

Cited by 7 publications

References 9 publications

Cortical microstructure and hemispheric specialization – a diffusion-imaging analysis in younger and older adults

Cortical microstructure and hemispheric specialization – a diffusion-imaging analysis in younger and older adults

Teaching Video Neuro Images : Apraxia of eyelid closure following right hemispheric infarction

Blepharospasm

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