Apraxia of Speech and Phonological Errors in the Diagnosis of Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia

Croot, Karen; Ballard, Kirrie J.; Leyton, Cristian E.; Hodges, John R.

doi:10.1044/1092-4388(2012/11-0323)

Cited by 107 publications

(69 citation statements)

References 31 publications

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“…In svPPA and lvPPA, a slow rate of speech can result from word-finding difficulties, 27,28 whereas slow or halting speech in nvPPA can arise from agrammatism, apraxia of speech, and oral apraxia. 28 The speech profile of lvPPA is dominated by phonologic sound substitutions (phonemic paraphasias) in the absence of motor speech errors 6,28 and individuals with nvPPA can present with consonant and vowel distortions, groping, prolonged phonemes, and excess and equal stress. 29 In line with the diagnostic criteria for bvFTD, the reduced rate of speech observed in patients with bvFTD compared to controls could arise from deficits in executive functioning rather than overt issues relating to speech motor planning or semantic/lexical retrieval.…”

Section: -24mentioning

confidence: 99%

Motor speech signature of behavioral variant frontotemporal dementia

et al. 2017

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Objective: To provide a comprehensive description of motor speech function in behavioral variant frontotemporal dementia (bvFTD).Methods: Forty-eight individuals (24 bvFTD and 24 age-and sex-matched healthy controls) provided speech samples. These varied in complexity and thus cognitive demand. Their language was assessed using the Progressive Aphasia Language Scale and verbal fluency tasks. Speech was analyzed perceptually to describe the nature of deficits and acoustically to quantify differences between patients with bvFTD and healthy controls. Cortical thickness and subcortical volume derived from MRI scans were correlated with speech outcomes in patients with bvFTD.Results: Speech of affected individuals was significantly different from that of healthy controls. The speech signature of patients with bvFTD is characterized by a reduced rate (75%) and accuracy (65%) on alternating syllable production tasks, and prosodic deficits including reduced speech rate (45%), prolonged intervals (54%), and use of short phrases (41%). Groups differed on acoustic measures derived from the reading, unprepared monologue, and diadochokinetic tasks but not the days of the week or sustained vowel tasks. Variability of silence length was associated with cortical thickness of the inferior frontal gyrus and insula and speech rate with the precentral gyrus. Conclusions:One in 8 patients presented with moderate speech timing deficits with a further twothirds rated as mild or subclinical. Subtle but measurable deficits in prosody are common in bvFTD and should be considered during disease management. Language function correlated with speech timing measures derived from the unprepared monologue only. Neurology ® 2017;89:837-844 GLOSSARY ALS 5 amyotrophic lateral sclerosis; AMR 5 alternating motion rate; bvFTD 5 behavioral variant of frontotemporal dementia; CBD 5 corticobasal degeneration; CI 5 confidence interval; DDK 5 diadochokinesis; FTD 5 frontotemporal dementia; lvPPA 5 logopenic variant primary progressive aphasia; nvPPA 5 nonfluent variant primary progressive aphasia; PALS 5 Progressive Aphasia Language Scale; PPA 5 primary progressive aphasia; PSP 5 progressive supranuclear palsy; ROI 5 region of interest; SMR 5 sequential motion rate; svPPA 5 semantic variant primary progressive aphasia.

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confidence: 99%

Motor speech signature of behavioral variant frontotemporal dementia

et al. 2017

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“…O termo descritivo "logopênica" foi introduzido para designar um tipo de prejuízo da linguagem que parecia peculiar à APP, mas sem que propusesse nenhum critério diagnóstico (LEYTON; HODGES, 2013). O Consenso Internacional de critérios para o diagnóstico da APP sugeriu que a apraxia do discurso fosse considerada como uma das duas características essenciais da versão agramática da DFTL, enquanto " erros fonológicos na ausência de distúrbios motores da fala" caracterizaria a variante logopênica (CROOT et al, 2012;GORNO-TEMPINI et al, 2011).…”

Section: Afasia Progressiva Primáriaunclassified

Degeneração Lobar Frontotemporal: Polêmicas E Desafios

Breda¹,

Gomes

2016

Cad. Pedagógico

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Resumo: As degenerações lobares frontotemporais constituem a segunda causa mais frequente de demência de início precoce, afetando indivíduos que se encontram muitas vezes em idade produtiva. A avaliação neuropsicológica é uma das principais ferramentas para o monitoramento da evolução do processo demencial, sendo um instrumento sensível à identificação de disfunções cognitivas e capaz de direcionar hipóteses diagnósticas. O presente artigo caracteriza-se como uma revisão de literatura não sistemática sobre a temática da degeneração lobar frontotemporal com o foco na avaliação neuropsicológica. Na busca dos artigos utilizou-se o Indexador Medline e a base Portal de Periódicos do CAPES, por consistirem em bases multidisciplinares que reúnem artigos estrangeiros, bem como teses e dissertações brasileiras. Foram selecionados vinte e cinco dentre os cinquenta artigos pesquisados com o foco na área cognitivocomportamental. A pesquisa delimitou o tempo de produção dos artigos nos últimos dez anos utilizando os seguintes termos como palavras-chaves: frontotemporal lobe degeneration, neuropsychological assessment, frontotemporal dementia, degeneração lobar frontotemporal, avaliação neuropsicológica e demência frontotemporal. O artigo revisa a temática da degeneração lobar frontotemporal, abordando brevemente o histórico do conceito e descobertas na área da patologia cerebral, acompanhando a evolução dos critérios diagnósticos e diferenciais das diversas variantes e suas manifestações clínicas. Revisa ainda pesquisas recentes acerca dos perfis cognitivo-comportamentais esperados em cada variante em bateria de avaliação das funções mentais, tecendo considerações sobre a avaliação neuropsicológica nesse contexto. Devese conceber as funções cognitivas como processos conectados em complexas redes neurais, bem como relativizar marcadores frente ao aprofundamento dos conhecimentos na área.Palavras-chave: Degeneração lobar frontotemporal. Avaliação neuropsicológica. Demência frontotemporal.

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“…Although pure AOS has been defined as a disruption of speech motor planning and/or programming following intact phonological encoding, phonological encoding impairments may coexist with AOS (Ballard, Granier, & Robin, 2000;Code, 1998;Croot, Ballard, Leyton, & Hodges, 2012;Duffy, 2005;Laganaro, 2012;McNeil, Robin, & Schmidt, 2009;Rogers, Redmond, & Alarcon, 1999).…”

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confidence: 98%

Phonological encoding in apraxia of speech and aphasia

2013

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Background: Apraxia of speech (AOS) is considered a speech motor planning/programming disorder. While it is possible that co-occurring phonological impairments exist, the speech motor planning/programming deficit often makes it difficult to assess the phonological encoding stage directly. Studies using online methods have suggested that activation of phonological information may be protracted in AOS. Aims: The present study was designed to investigate the integrity of the phonological encoding stage in AOS and aphasia. We tested two specific hypotheses, the Frame Hypothesis and the Segment Hypothesis. According to the Frame Hypothesis, speakers with AOS have an impairment in retrieving metrical frames (e.g., number of syllables); according to the Segment Hypothesis, speakers with AOS have an impairment in retrieving segments (e.g., consonants). Methods & Procedures: Four individuals with AOS and varying degrees of aphasia, two speakers with aphasia, and 13 age-matched control speakers completed an online priming task in which participants name pictures in sets that do or do not share number of syllables (e.g., balcony-coconut-signature vs. balcony-carrot-sock), the initial consonant (e.g., carpenter-castle-cage vs. carpenter-beaver-sun), or both (e.g., boomerang-butterflybicycle vs. boomerang-sausage-cat). Error rates and reaction times were measured. Outcomes & Results: Data for controls replicated previous literature. Reaction time data supported the Segment Hypothesis for speakers with AOS and for one speaker with aphasia without AOS, with no differences in pattern from controls for the other speaker with aphasia without AOS. Conclusions: These results suggest that speakers with AOS may also have difficulties at the phonological encoding stage. Theoretical and clinical implications of these findings are discussed.

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Apraxia of Speech and Phonological Errors in the Diagnosis of Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia

Abstract: Attention to AOS and phonological errors may help counter some of the inherent limitations of diagnosis-by-exclusion in the current International Consensus Criteria for diagnosing PPA.

Cited by 107 publications

References 31 publications

Motor speech signature of behavioral variant frontotemporal dementia

Motor speech signature of behavioral variant frontotemporal dementia

Degeneração Lobar Frontotemporal: Polêmicas E Desafios

Phonological encoding in apraxia of speech and aphasia

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