April 2016 at a glance. Focus on cardiac remodeling, biomarkers and treatment

Metra, Marco

doi:10.1002/ejhf.542

European J of Heart Fail

2016

DOI: 10.1002/ejhf.542

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April 2016 at a glance. Focus on cardiac remodeling, biomarkers and treatment

Marco Metra

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2020

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Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Zhao

2020

Oxidative Medicine and Cellular Longevity

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Cardiac remodeling describes a series of structural and functional changes in the heart after myocardial infarction (MI). Adverse post-MI cardiac remodeling directly jeopardizes the recovery of cardiac functions and the survival rate in MI patients. Several classes of drugs are proven to be useful to reduce the mortality of MI patients. However, it is an ongoing challenge to prevent the adverse effects of cardiac remodeling. The present review aims to identify the pharmacological therapies from the existing clinical drugs for the treatment of adverse post-MI cardiac remodeling. Post-MI cardiac remodeling is a complex process involving ischemia/reperfusion, inflammation, cell death, and deposition of extracellular matrix (ECM). Thus, the present review included two parts: (1) to examine the basic pathophysiology in the cardiovascular system and the molecular basis of cardiac remodeling and (2) to identify the pathological aspects of cardiac remodeling and the potential of the existing pharmacotherapies. Ultimately, the present review highlights drug repositioning as a strategy to discover effective therapies from the existing drugs against post-MI cardiac remodeling.

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Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Zhao

2020

Oxidative Medicine and Cellular Longevity

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April 2016 at a glance. Focus on cardiac remodeling, biomarkers and treatment

Cited by 1 publication

References 9 publications

Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

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