2003
DOI: 10.1097/01.brs.0000090835.45437.7f
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Aprotinin Reduces Blood Loss During Spinal Surgery in Children

Abstract: This randomized, blinded study suggests that aprotinin significantly decreased blood loss and transfusion requirements in pediatric and adolescent scoliosis surgical patients at increased risk for intraoperative bleeding.

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Cited by 103 publications
(60 citation statements)
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“…His review demonstrated that the use of aprotinin decreased blood loss significantly and did not increase the risk for renal failure or DVT. Additional reports have not demonstrated an increase in DVT formation in patients receiving aprotinin during spinal surgery, although the numbers are too small to prove that a difference is not present [1,14]. According to Cole et al [1] venous duplex studies of the lower limbs of pediatric neuromuscular scoliosis patients, revealed no thrombus formation in aprotinin treated patients and 13% in the control group, although this was not statistically significant.…”
Section: Discussionmentioning
confidence: 88%
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“…His review demonstrated that the use of aprotinin decreased blood loss significantly and did not increase the risk for renal failure or DVT. Additional reports have not demonstrated an increase in DVT formation in patients receiving aprotinin during spinal surgery, although the numbers are too small to prove that a difference is not present [1,14]. According to Cole et al [1] venous duplex studies of the lower limbs of pediatric neuromuscular scoliosis patients, revealed no thrombus formation in aprotinin treated patients and 13% in the control group, although this was not statistically significant.…”
Section: Discussionmentioning
confidence: 88%
“…Several studies have previously shown that aprotinin is effective in decreasing surgical blood loss in various fields of orthopaedic surgery [1,14]. A report by Cole et al [1] demonstrated a favorable outcome in pediatric spinal surgery with the use of aprotinin: on average, the aprotinin group required only 1.1 versus 2.2 units of blood for the placebo group.…”
Section: Discussionmentioning
confidence: 99%
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“…Spinal fusion surgery is often associated with major blood loss, which is sometimes significant, requiring the transfusion of blood or blood products (1). Blood loss can be an acute problem not only in major deformity surgery but also in less extensive fusion procedures.…”
Section: Introductionmentioning
confidence: 99%