Aptamer-based biosensors for virus protein detection

Lou, Beibei; Liu, Yanfei; Shi, Meilin; Chen, Jun; Li, Ké; Tan, Yifu; Chen, Liwei; Wu, Yuwei; Wang, Ting; Liu, Xiaoqin; Jiang, Ting; Peng, Dongming; Liu, Zhenbao

doi:10.1016/j.trac.2022.116738

Cited by 59 publications

(27 citation statements)

References 202 publications

(257 reference statements)

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“…In the current circumstance, aptamer-based biosensors can be an inexpensive and perfect tool for the SARS-CoV-2 diagnosis. Moreover, the usefulness of aptasensor in the detection of the SARS-CoV-2 virus and its structural proteins has already been demonstrated by many reports as listed in Table 1 ( Lou et al, 2022 ; Mandal et al, 2021 ; Wandtke et al, 2022 ). The S and N proteins are the most widely used biomarker for the detection of SARS-CoV-2.…”

Section: Bio-recognition Elements For Sars-cov-2 Biomarkersmentioning

confidence: 96%

Emerging trends in point-of-care biosensing strategies for molecular architectures and antibodies of SARS-CoV-2

Karuppaiah

Vashist

Nair

et al. 2023

Biosensors and Bioelectronics: X

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Section: Bio-recognition Elements For Sars-cov-2 Biomarkersmentioning

confidence: 96%

Emerging trends in point-of-care biosensing strategies for molecular architectures and antibodies of SARS-CoV-2

Karuppaiah

Vashist

Nair

et al. 2023

Biosensors and Bioelectronics: X

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“…With the in-depth research on the mechanism of SARS-CoV-2 infection and the development of neutralizing aptamers, aptamer-based treatment as a strategy to combat the COVID-19 pandemic has attracted the attention of more and more researchers. [44] In addition, based on the chemistry of nucleic acids, aptamers can be flexibly designed to be easily combined with other technologies, such as nanostructures, to improve their performance and application in both the detection and treatment of SARS-CoV-2. [45] Furthermore, aptamers also provide valuable reference for studying the SARS-CoV-2 infection mechanism and vaccine design.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

Aptamer‐based strategies against SARS‐CoV‐2 viruses

Huang

Chen

Zhang

et al. 2023

BMEMat

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The COVID‐19 pandemic, caused by SARS‐CoV‐2, has seriously threatened human life and security in recent years and has had a serious impact on economic development. A range of strategies, including antibodies, small‐molecule agents and vaccines, have been developed and widely used to combat SARS‐CoV‐2. However, the uncertain development and susceptibility to mutation of SARS‐CoV‐2 pose challenges to these approaches, making it necessary to develop a broader range of strategies to complement and expand the diversity of attacks against SARS‐CoV‐2. As promising tools against SARS‐CoV‐2, aptamers have attracted wide attention due to their unique molecular properties. In this review, we survey SARS‐CoV‐2 aptamers and aptamer‐based detection tools as well as aptamer‐based therapeutics. In addition, we analyze the potential value of aptamers in the investigation of SARS‐CoV‐2 infection mechanism and vaccine design. Finally, we look forward to the future development direction of aptamers against SARS‐CoV‐2 or other viruses.

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“…Electrochemical nucleic acid (NA) biosensor combines the sensitivity of electrical analysis with the inherent bioselectivity of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) (Lou et al, 2022). It uses the affinity of single-stranded DNA/RNA to its complementary chain and is used to detect the complementary sequence of NA on the basis of hybridization.…”

Section: Electrochemical Dna Biosensing Of Oral Diseasesmentioning

confidence: 99%

“…For periodontal disease detection, Satit et al demonstrated a quartz crystal microbalance (QCM) immunoassay for quantitative evaluation of periodontal bacteria, Actinomycetes (Liu et al, 2022). An immunological sensor was built on the gold surface of the QCM device using a self-assembled monolayer of 11-mercaptodecanoic acid (11-MUA).…”

Section: Composition Of Microorganismsmentioning

confidence: 99%

Advances in electrochemical biosensors for the detection of common oral diseases

Han

Liu

Guan

et al. 2023

Preprint

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With the advancement of society and people’s knowledge of oral health, the prevention of oral illnesses such as dental caries, periodontal disease, oral cancer, oral mucosal disease, salivary gland disease, and so on has become the primary focus of current health status and treatment. Although treatment for these diseases has focused on removing lesions or inhibiting progression, early detection has always been the focus of clinical research. And the non-invasive diagnosis is now the primary goal of clinical diagnosis. Meanwhile, the electrochemical approach can satisfy this need while also achieving a speedy and reliable diagnosis, giving patients a more comfortable option. And noninvasive detection of specific diseases can be achieved by detecting markers carried in body fluids. Therefore, in the context of disease, pathophysiological progress and electrochemical-assisted diagnosis form a close relationship, providing a basis for the detection of oral disease related indicators. As a result, this review comprehensively summarizes the detection and diagnosis of common oral diseases using electrochemical sensing technology and provides important insights for the development of electrochemical biosensors for the early detection of common oral diseases.

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Aptamer-based biosensors for virus protein detection

Cited by 59 publications

References 202 publications

Emerging trends in point-of-care biosensing strategies for molecular architectures and antibodies of SARS-CoV-2

Emerging trends in point-of-care biosensing strategies for molecular architectures and antibodies of SARS-CoV-2

Aptamer‐based strategies against SARS‐CoV‐2 viruses

Advances in electrochemical biosensors for the detection of common oral diseases

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