Aptamer conjugated polydopamine-coated gold nanoparticles as a dual-action nanoplatform targeting β-amyloid peptide for Alzheimer's disease therapy

Abstract

The accumulations and deposits of amyloid beta (Aβ) peptide are the important pathological hallmark of Alzheimer’s disease (AD).Development of multifunctional agents that can effectively clear Aβ aggregates is one of...

Design of aggregation-induced emission-active fluorogen-based nanoparticles for imaging and scavenging Alzheimer's β-amyloid by photo-oxygenation

“…4B). 62 The fluorescence curves of Aβ treated with irradiation or T-LD NPs were similar to that of Aβ alone. However, when Aβ was incubated with T-LD NPs under laser irradiation, the fluorescence intensity significantly reduced (Fig.…”

Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy

“…70 Two years later, Qin et al designed aptamer conjugated polydopamine-coated NPs (Au@PDA-Apt NPs) for AD therapy by targeting Ab 1-40 peptides. 71 The results illustrated that Au@PDA-Apt NPs could efficiently inhibit Ab 1-40 monomer fibrillization and depolymerize the mature Ab 1-40 fibrils. Given the high incidence of AD, it is necessary to develop noninvasive tools for AD diagnosis.…”

Antibacterial and antibiofilm activities of zeolitic imidazolate framework-67 for dental caries prevention

“…The biocompatibility of ZIF-67 was examined by the CCK-8 experiment [8] . Mouse gingival fibroblast (L929) cells were inoculated for 24 hours into a 96-well transparent plate.…”