Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy

Chen, Zhongyuan; Peng, Yueting; Li, Yichao; Xie, Xiaoxue; Wei, Xiaodan; Yang, Geng; Zhang, Hanxi; Li, Ningxi; Li, Tingting; Qin, Xiang; Li, Shun; Wu, Chunhui; You, Fengming; Yang, Hong; Liu, Yiyao

doi:10.1021/acsnano.1c06667

Cited by 44 publications

(37 citation statements)

References 51 publications

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“…Biodistribution of MPDA@Fe 3 O 4 -Era was investigated in a 4T1 tumor-bearing mouse model. For in vivo monitoring, Cy5 labeled MPDA@Fe 3 O 4 -Era were fabricated to track the distribution of MPDA@Fe 3 O 4 -Era in mice [ 30 ]. After intravenously injected with Cy5-labeled MPDA@Fe 3 O 4 -Era, the fluorescence signals increased within 12 h and then decayed at 24 h, ascribe to the EPR effect of NPs ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory

Xie

Chen

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory

Xie

Chen

et al. 2022

Materials Today Bio

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“…Another formulation for MDT therapy by Chen et al used AS1411 targeted zinc-doped iron oxide nano octahedra co-loaded with DOX and HSP70/HSP90 siRNA 178 . Remarkable tumor growth inhibition in 4T1 xenografts was achieved after a single injection of the nanoprobe and AMF application.…”

Section: Aptamers For Theranostic Applicationsmentioning

confidence: 99%

Aptamers used for molecular imaging and theranostics - recent developments

Bohrmann¹,

Burghardt²,

Haynes³

et al. 2022

Theranostics

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Aptamers are single stranded oligonucleotides that fold into three dimensional structures and are able to recognize a variety of molecular targets. Due to the similarity to antibodies with regards to specificity and affinity and their chemical versatility, aptamers are increasingly used to create targeted probes for in vivo molecular imaging and therapy. Hence, aptamer-based probes have been utilized in practically all major imaging modalities such as nuclear imaging, magnetic resonance imaging, x-ray computed tomography, echography and fluorescence imaging, as well as newer modalities such as surface enhanced Raman spectroscopy. Aside from targeting, aptamers have been used for the creation of sensors that allow the localized detection of cellular markers such as ATP in vivo . This review focuses on in vivo studies of aptamer-based probes for imaging and theranostics since the comprehensive overview by Bouvier-Müller and Ducongé in 2018.

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“…First, the design of MBs is simple. MB sequence and target sequence can be designed and verified by software such as Beacon Designer and NCBI Primer-BLAST, which ensures the accuracy of the assay . Additionally, the synthesis of MB is simple and inexpensive.…”

Section: Mbs: Structure Classification and Their Applications In Rna ...mentioning

confidence: 99%

Recent Advancements in Nanosystem-Based Molecular Beacons for RNA Detection and Imaging

Yang

Song

Wang

et al. 2022

ACS Appl. Nano Mater.

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As one of the two nucleic acids used by extant biochemistry, RNA is of great importance for cellular function and development, and its expression can affect cell homeostasis. Therefore, accurate detection of RNA is the key contributor to disease diagnosis, including tumor detection. Compared with conventional RNA detection methods, molecular beacons (MBs) have high selectivity for target molecules detection, which have been widely used in RNA detection. However, the background fluorescence of typical MBs will seriously affect the detection sensitivity and accuracy. In addition, the poor affinity and weak resistance to the nuclease digestion of MBs also limit its applications. With the development of nanotechnology, many nanomaterials with fluorescence quenching ability have been widely used as quenchers and carriers for MBs to construct nanoprobes (Nano-MBs). In this review, we summarize the recent developments of Nano-MBs in RNA detection and imaging over the past decade. First, the structure, working principle, and classification of MBs are discussed. Then, we introduce several typical Nano-MBs based on gold nanoparticles, polydopamine, graphene oxide, molybdenum disulfide, and quantum dots. Particular emphasis is placed on the application of Nano-MBs in mRNA and miRNA detection and imaging in the diagnosis and treatment of diseases, as well as in cancer. Finally, the current challenges and future perspectives are also discussed.

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Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy

Cited by 44 publications

References 51 publications

Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory

Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory

Aptamers used for molecular imaging and theranostics - recent developments

Recent Advancements in Nanosystem-Based Molecular Beacons for RNA Detection and Imaging

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