Aptamer-drug conjugates: New probes for imaging and targeted therapy

Li, Pingping; Ga, Lu; Aodeng, Gerile; Wang, Yong; Ai, Jun

doi:10.1016/j.biosx.2022.100126

Cited by 6 publications

(4 citation statements)

References 171 publications

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“…A variety of therapeutic agents and biological imaging agents can be carried by nanocarriers, allowing for greater cytotoxic drug payload [140]. The use of nano-based technologies for imaging, diagnostics, and radiation therapy has increased in clinical settings [141][142][143]. Aptamers' in vivo applications are limited due to their vulnerability to nuclease degradation and fast renal excretion.…”

Section: Aptamer-functionalized Nanoparticles In Drug Delivery Systemsmentioning

confidence: 99%

“…Aptamers' in vivo applications are limited due to their vulnerability to nuclease degradation and fast renal excretion. To overcome these limitations, several attempts have been made to modify aptamers to enhance their binding affinity with the target, improve their stability, and prevent degradation by in vivo nucleases [142,144]. In addition to adjusting the SELEX protocol, nanocarriers can improve and modify aptamers for biological applications and enhance their stability and pharmacokinetics in vivo [142].…”

Section: Aptamer-functionalized Nanoparticles In Drug Delivery Systemsmentioning

confidence: 99%

“…The second method is called "DNA origami" which is a bottom-up assembly process that involves folding a long single-stranded DNA scaffold of a few thousand nucleotides and using hundreds of short staple strands to create complex 2D and 3D structures [145,146]. Moreover, radiosensitizersaptamers conjugated with nanoparticles radiotherapy efficiency is increased [142].…”

Section: Aptamer-functionalized Nanoparticles In Drug Delivery Systemsmentioning

confidence: 99%

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Aptamers as an approach to targeted cancer therapy

Mahmoudian,

Ahmari,

Shabani

et al. 2024

Cancer Cell Int

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Conventional cancer treatments can cause serious side effects because they are not specific to cancer cells and can damage healthy cells. Aptamers often are single-stranded oligonucleotides arranged in a unique architecture, allowing them to bind specifically to target sites. This feature makes them an ideal choice for targeted therapeutics. They are typically produced through the systematic evolution of ligands by exponential enrichment (SELEX) and undergo extensive pharmacological revision to modify their affinity, specificity, and therapeutic half-life. Aptamers can act as drugs themselves, directly inhibiting tumor cells. Alternatively, they can be used in targeted drug delivery systems to transport drugs directly to tumor cells, minimizing toxicity to healthy cells. In this review, we will discuss the latest and most advanced approaches to using aptamers for cancer treatment, particularly targeted therapy overcoming resistance to conventional therapies.

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Section: Aptamer-functionalized Nanoparticles In Drug Delivery Systemsmentioning

confidence: 99%

Section: Aptamer-functionalized Nanoparticles In Drug Delivery Systemsmentioning

confidence: 99%

Section: Aptamer-functionalized Nanoparticles In Drug Delivery Systemsmentioning

confidence: 99%

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Aptamers as an approach to targeted cancer therapy

Mahmoudian,

Ahmari,

Shabani

et al. 2024

Cancer Cell Int

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“…Such aptamer–polymer chimeras improve the specificity of drug delivery by targeting various surface biomarkers, including the epithelial cell adhesion protein molecule (EpCAM) on the surface of breast adenocarcinoma and colon cancer cells [ 79 , 80 ]; nucleolin on acute myeloid leukemia, gliomas, kidney tumors, etc. [ 81 , 82 , 83 , 84 , 85 ]; PSMA on the surface of prostate tumor cells [ 86 ], and mucin-1 on lung epithelial cancer cells [ 87 , 88 ]. The increased biodegradability and biocompatibility of copolymers or liposomes open up excellent opportunities for their conjugation with aptamers for the targeted drug delivery [ 52 ].…”

Section: Applications Of Aptamersmentioning

confidence: 99%

Aptamers Enhance Oncolytic Viruses’ Antitumor Efficacy

et al. 2022

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Oncolytic viruses are highly promising for cancer treatment because they target and lyse tumor cells. These genetically engineered vectors introduce therapeutic or immunostimulatory genes into the tumor. However, viral therapy is not always safe and effective. Several problems are related to oncolytic viruses’ targeted delivery to the tumor and immune system neutralization in the bloodstream. Cryoprotection and preventing viral particles from aggregating during storage are other critical issues. Aptamers, short RNA, or DNA oligonucleotides may help to crawl through this bottleneck. They are not immunogenic, are easily synthesized, can be chemically modified, and are not very demanding in storage conditions. It is possible to select an aptamer that specifically binds to any target cell, oncolytic virus, or molecule using the SELEX technology. This review comprehensively highlights the most important research and methodological approaches related to oncolytic viruses and nucleic acid aptamers. Here, we also analyze possible future research directions for combining these two methodologies to improve the effectiveness of cancer virotherapy.

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Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities

Maiti

Patel

et al. 2023

Arch. Pharm. Res.

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Aptamer-drug conjugates: New probes for imaging and targeted therapy

Cited by 6 publications

References 171 publications

Aptamers as an approach to targeted cancer therapy

Aptamers as an approach to targeted cancer therapy

Aptamers Enhance Oncolytic Viruses’ Antitumor Efficacy

Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities

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