Aptamer-functionalized chitosan magnetic nanoparticles as a novel adsorbent for selective extraction of ochratoxin A

Wang, Shuwen; Niu, Rui; Yang, Yamei; Zhou, Xinghua; Luo, Shilong; Zhang, Chen; Wang, Yun

doi:10.1016/j.ijbiomac.2020.03.035

Cited by 41 publications

(8 citation statements)

References 37 publications

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“…For example, it has been assigned to ν as (COO – ) ,, or N–H bending, ,,, however, this band in our samples cannot simply be assigned to either of these bonds. Especially, because this and a very broad band at around 3420 (which may also be a result of N–H bending − ) can be the result of O–H stretching of observed water. Metal–organic structures can contain adsorbed water .…”

Section: Resultsmentioning

confidence: 97%

From Low to High Saturation Magnetization in Magnetite Nanoparticles: The Crucial Role of the Molar Ratios Between the Chemicals

et al. 2022

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In this study, a comprehensive characterization of iron oxide nanoparticles synthesized by using a simple one-pot thermal decomposition route is presented. In order to obtain monodisperse magnetite nanoparticles with high saturation magnetization, close to the bulk material, the molar ratios between the starting materials (solvents, reducing agents, and surfactants) were varied. Two out of nine conditions investigated in this study resulted in monodisperse iron oxide nanoparticles with high saturation magnetization (90 and 93% of bulk magnetite). The X-ray diffraction analyses along with the inspection of the lattice structure through transmission electron micrographs revealed that the main cause of the reduced magnetization in the other seven samples is likely due to the presence of distortion and microstrain in the particles. Although the thermogravimetric analysis, Raman and Fourier transform infrared spectroscopies confirmed the presence of covalently bonded oleic acid on the surface of all the samples, the particles with higher polydispersity and the lowest surface coating molecules showed the lowest saturation magnetization. Based on the observed results, it could be speculated that the changes in the kinetics of the reactions, induced by varying the molar ratio of the starting chemicals, can lead to the production of the particles with higher polydispersity and/or lattice deformation in their crystal structures. Finally, it was concluded that the experimental conditions for obtaining high-quality iron oxide nanoparticles, particularly the molar ratios and the heating profile, should not be chosen independently; for any specific molar ratio, there may exist a specific heating profile or vice versa. Because this synthetic consideration has rarely been reported in the literature, our results can give insights into the design of iron oxide nanoparticles with high saturation magnetization for different applications.

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Section: Resultsmentioning

confidence: 97%

From Low to High Saturation Magnetization in Magnetite Nanoparticles: The Crucial Role of the Molar Ratios Between the Chemicals

et al. 2022

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“…The functional chitosan MNPs (Fe 3 O 4 @CTS@Apt) developed by Fang et al can be used as a new adsorbent for selectively capturing OTA. The recovery of the modified corn powder was 91.3% and 99.1% . Mycotoxins are usually detected in foods rather than fungal cells.…”

Section: Microbial Toxinsmentioning

confidence: 97%

“…The recovery of the modified corn powder was 91.3% and 99.1%. 129 Mycotoxins are usually detected in foods rather than fungal cells. Although a variety of separation and enrichment techniques have been developed for sample pretreatment of mycotoxins, problems such as low levels of mycotoxins and the coexistence of multiple mycotoxins make direct rapid, precise, and sensitive quantification challenging.…”

Section: Microbial Toxinsmentioning

confidence: 99%

Magnetic Nanoseparation Technology for Efficient Control of Microorganisms and Toxins in Foods: A Review

Kang

Shi

Sun

et al. 2022

J. Agric. Food Chem.

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Outbreaks of foodborne diseases mediated by food microorganisms and toxins remain one of the leading causes of disease and death worldwide. It not only poses a serious threat to human health and safety but also imposes a huge burden on health care and socioeconomics. Traditional methods for the removal and detection of pathogenic bacteria and toxins in various samples such as food and drinking water have certain limitations, requiring a rapid and sensitive strategy for the enrichment and separation of target analytes. Magnetic nanoparticles (MNPs) exhibit excellent performance in this field due to their fascinating properties. The strategy of combining biorecognition elements with MNPs can be used for fast and efficient enrichment and isolation of pathogens. In this review, we describe new trends and practical applications of magnetic nanoseparation technology in the detection of foodborne microorganisms and toxins. We mainly summarize the biochemical modification and functionalization methods of commonly used magnetic nanomaterial carriers and discuss the application of magnetic separation combined with other instrumental analysis techniques. Combined with various detection techniques, it will increase the efficiency of detection and identification of microorganisms and toxins in rapid assays.

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“…Notably, MSPE has become the primary method of analyte pretreatment in many fields due to its ability to rapidly agglomerate or disperse in analyte solutions under the magnetic field and its ease of operation without centrifugation [16][17][18]. In MSPE, aptamers or antibodies as the major recognition elements coupled to magnetic nanoparticles can achieve pre-treatment of samples with diverse targets in different matrices [19][20][21]. Although antibodies exhibit high specificity, the high cost and complexity of production limit the use of antibodies.…”

Section: Instructionmentioning

confidence: 99%

High‐throughput extraction and automatic purification of alternariol from edible and medicinal herbs based on aptamer‐functionalized magnetic nanoparticles

Yang,

Zhao,

Wang

et al. 2024

J of Separation Science

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Mycotoxin contamination is widespread in plants and herbs, posing serious threats to the consumer and human health. Of them, alternariol (AOH) has attracted great attention as an “emerging” mycotoxin in medicinal herbs. However, a specific and high‐throughput extraction method for AOH is currently lacking. Thus, developing an efficient pre‐treatment technique for AOH detection is extremely vital. Here, a novel automated magnetic solid‐phase extraction method was proposed for the highly efficient extraction of AOH. Combining the aptamer‐functionalized magnetic nanoparticles (AMNPs) and the automatic purification instrument, AOH could be extracted in medicinal herbs in high throughput (20 samples) and a short time (30 min). The main parameters affecting extraction were optimized, and the method was finally carried out by incubation AMNPs with 3 mL of sample solution for 10 min, and then desorption in 75% methanol for liquid‐phase detection. Under optimal conditions, good reproducibility, stability, and selectivity were realized with an adsorption capacity of 550.84 ng/mg. AOH extraction in three edible herbs showed good resistance to matrix interference with recovery rates from 86% to 111%. In combination with AMNPs and the automatic purification instrument, high‐throughput and labor‐free extraction of AOH in different complex matrices was achieved, which could be extended in other complex matrices.

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Aptamer-functionalized chitosan magnetic nanoparticles as a novel adsorbent for selective extraction of ochratoxin A

Cited by 41 publications

References 37 publications

From Low to High Saturation Magnetization in Magnetite Nanoparticles: The Crucial Role of the Molar Ratios Between the Chemicals

From Low to High Saturation Magnetization in Magnetite Nanoparticles: The Crucial Role of the Molar Ratios Between the Chemicals

Magnetic Nanoseparation Technology for Efficient Control of Microorganisms and Toxins in Foods: A Review

High‐throughput extraction and automatic purification of alternariol from edible and medicinal herbs based on aptamer‐functionalized magnetic nanoparticles

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