Aptamer-functionalized micelles for targeted cancer therapy

Salahpour‐Anarjan, Fatemeh; Zare, Faraz; Hosseini, Farnaz; Ahranjani, Sara Davari; Alipour, Mahnaz; Gozali, Elahe

doi:10.1016/b978-0-323-85881-6.00015-4

Cited by 1 publication

(2 citation statements)

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“…Furthermore, their biocompatibility and ability to incorporate various therapeutic agents make micelles versatile carriers, allowing for the co-delivery of multiple drugs [65] or imaging agents [66], enhancing therapeutic efficacy [63], and personalized medicine strategies [67]. Hence, the assembly of aptamer-micelle conjugates demonstrates significant promise in recognizing cancer cells and has potential applications for in vivo drug delivery [68].…”

Section: Aptamer-micelle Conjugationmentioning

confidence: 99%

“…The micelle incorporates a targeting aptamer, with the aim of minimizing the therapeutic dosage and reducing off-target effects [68]. The dual redox/pH-sensitive poly (β-amino ester) copolymeric micelles are coupled with the CSRLSLPGSSSKpalmSSS peptide and TA1 aptamer as dual-targeting ligands for synergistic targeting in the 4T1 breast cancer model.…”

Section: Aptamer-micelle Conjugationmentioning

confidence: 99%

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Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Park,

Lee,

Park

2024

Biomedicines

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In recent years, the field of drug delivery has witnessed remarkable progress, driven by the quest for more effective and precise therapeutic interventions. Among the myriad strategies employed, the integration of aptamers as targeting moieties and stimuli-responsive systems has emerged as a promising avenue, particularly in the context of anticancer therapy. This review explores cutting-edge advancements in targeted drug-delivery systems, focusing on the integration of aptamers and stimuli-responsive platforms for enhanced spatial anticancer therapy. In the aptamer-based drug-delivery systems, we delve into the versatile applications of aptamers, examining their conjugation with gold, silica, and carbon materials. The synergistic interplay between aptamers and these materials is discussed, emphasizing their potential in achieving precise and targeted drug delivery. Additionally, we explore stimuli-responsive drug-delivery systems with an emphasis on spatial anticancer therapy. Tumor microenvironment-responsive nanoparticles are elucidated, and their capacity to exploit the dynamic conditions within cancerous tissues for controlled drug release is detailed. External stimuli-responsive strategies, including ultrasound-mediated, photo-responsive, and magnetic-guided drug-delivery systems, are examined for their role in achieving synergistic anticancer effects. This review integrates diverse approaches in the quest for precision medicine, showcasing the potential of aptamers and stimuli-responsive systems to revolutionize drug-delivery strategies for enhanced anticancer therapy.

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