Aptamer-guided extracellular vesicle theranostics in oncology

Tran, Phuong Ha Lien; Xiang, Dongxi; Nguyen, Tuong N.G.; Tran, Thao T.D.; Chen, Qian; Wang, Yin; Zhang, Yumei; Kong, Lingxue; Duan, Andrew; Chen, Kuisheng; Sun, Miomio; Li, Yong; Hou, Yingchun; Zhu, Y.; Ma, Yongchao; Jiang, Guoqin; Duan, Wei

doi:10.7150/thno.39706

Cited by 60 publications

(50 citation statements)

References 150 publications

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“…Aptamer functionalized‐exosomes play a role in cell to cell communication, transporting diagnostic agents such as RNA and proteins, among others. [ 139,140 ]…”

Section: Exosomes As Drug Delivery Systemsmentioning

confidence: 99%

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Advances in Exosomes‐Based Drug Delivery Systems

Gutiérrez-Millán

Díaz

Lanao

et al. 2020

Macromolecular Bioscience

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Exosomes, a subgroup of extracellular vesicles, are important mediators of long‐distance intercellular communication and are involved in a diverse range of biological processes such as the transport of lipids, proteins, and nucleic acids. Researchers, seeing the problems caused by the toxic effects and clearance of synthetic nanoparticles, consider exosomes as an interesting alternative to such nanoparticles in the specific and controlled transport of drugs. In recent years, there have been remarkable advances in the use of exosomes in cancer therapeutics or for treating neurological diseases, among other applications. The objective of this work is to analyze studies focused on exosomes used in drug delivery system, present and future applications in this field of research are discussed based on the results obtained.

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“…Aptamer functionalized‐exosomes play a role in cell to cell communication, transporting diagnostic agents such as RNA and proteins, among others. [ 139,140 ]…”

Section: Exosomes As Drug Delivery Systemsmentioning

confidence: 99%

“…In this kind of system engineered aptamer exosomes are loaded with active molecules and targeted in vivo with different potential applications as shown in Figure 8 . [ 139 ]…”

Section: Exosomes As Drug Delivery Systemsmentioning

confidence: 99%

Advances in Exosomes‐Based Drug Delivery Systems

Gutiérrez-Millán

Díaz

Lanao

et al. 2020

Macromolecular Bioscience

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“…In addition, aptamers represent another low molecular weight targeting system. A comprehensive review of aptamer-guided EV theranostics in oncology is available elsewhere 63 . With respect to inflammation targeting, a recent study successfully modified EVs with DNA aptamers against an adhesion receptor, ICAM-3 grabbing non-integrin (DC-SIGN), for the targeted delivery of therapeutic RNAs to dendritic cells 64 .…”

Section: Engineering Evs As Smart Nanotherapeutics To Target Inflammamentioning

confidence: 99%

Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

Tang

Wang

et al. 2020

Theranostics

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Dysregulated inflammation is a complicated pathological process involved in various diseases, and the treatment of inflammation-linked disorders currently represents an enormous global burden. Extracellular vesicles (EVs) are nanosized, lipid membrane-enclosed vesicles secreted by virtually all types of cells, which act as an important intercellular communicative medium. Considering their capacity to transfer bioactive substances, both unmodified and engineered EVs are increasingly being explored as potential therapeutic agents or therapeutic vehicles. Moreover, as the nature's own delivery tool, EVs possess many desirable advantages, such as stability, biocompatibility, low immunogenicity, low toxicity, and biological barrier permeability. The application of EV-based therapy to combat inflammation, though still in an early stage of development, has profound transformative potential. In this review, we highlight the recent progress in EV engineering for inflammation targeting and modulation, summarize their preclinical applications in the treatment of inflammatory disorders, and present our views on the anti-inflammatory applications of EV-based nanotherapeutics.

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“…With these methods, drugs can be added in a pre-loading step by endogenous loading, in which the drugs are introduced in the sEV production stage, or they can be post-loaded with exogenous loading, in which the drugs are loaded after the isolation and purification steps of sEV production. Notably, sEVs have a shell composed of a lipid bilayer membrane and an aqueous core [82,83]. Thus, hydrophilic drugs are likely to localize to the aqueous core, whereas hydrophobic drugs tend to occupy the sEV membrane.…”

Section: The Application Of Lead Compounds As Drugs Loaded In Sevsmentioning

confidence: 99%

“…More information on engineering targeting ligands on sEVs can be found in other reviews as the methodologies mentioned in these articles may be applied to lead compound-loaded sEVs [ 81 , 97 , 110 , 133 ]. The actively targeted sEV delivery systems, however, are still on their way to gain as many achievements as other research branches in the field [ 83 ]. Of note, while developing these techniques, how to produce the sEVs in a fast, convenient, and cost-effective manner is another challenge.…”

Section: Challenges In Lead Compound-sevs Researchmentioning

confidence: 99%

Lead Compounds in the Context of Extracellular Vesicle Research

Tran

2020

Pharmaceutics

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Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine.

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Aptamer-guided extracellular vesicle theranostics in oncology

Cited by 60 publications

References 150 publications

Advances in Exosomes‐Based Drug Delivery Systems

Advances in Exosomes‐Based Drug Delivery Systems

Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

Lead Compounds in the Context of Extracellular Vesicle Research

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