2018
DOI: 10.1039/c8an00725j
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Aptamer immobilization on amino-functionalized metal–organic frameworks: an ultrasensitive platform for the electrochemical diagnostic of Escherichia coli O157:H7

Abstract: Herein, we report the development of an electrochemical biosensor for Escherichia coli O157:H7 diagnostic based on amino-functionalized metal-organic frameworks (MOFs) as a new generation of organic-inorganic hybrid nanocomposites. The electrical and morphological properties of MOFs were enhanced by interweaving each isolated MOF crystal with polyaniline (PANI). Subsequent attachment of the amine-modified aptamer to the polyanilinated MOFs was accomplished using glutaraldehyde (GA) as a cross-linking agent. Th… Show more

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Cited by 89 publications
(49 citation statements)
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“…In 2018, Shahrokhian and Ranjbar developed an electrochemical polyaniline/Cu‐MOF‐based biosensor for the direct detection of E. coli O157:H7 80. The pathway of this detection was based on the change of methylene blue reduction peak current before and after E. coli O157:H7 culture, which achieved rapid and sensitive detection of E. coli O157:H7 in the range of 21–2.1 × 10 7 CFU mL −1 with a detection limit of 2 CFU mL −1 .…”
Section: Biomedical Applications Of Mofsmentioning
confidence: 99%
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“…In 2018, Shahrokhian and Ranjbar developed an electrochemical polyaniline/Cu‐MOF‐based biosensor for the direct detection of E. coli O157:H7 80. The pathway of this detection was based on the change of methylene blue reduction peak current before and after E. coli O157:H7 culture, which achieved rapid and sensitive detection of E. coli O157:H7 in the range of 21–2.1 × 10 7 CFU mL −1 with a detection limit of 2 CFU mL −1 .…”
Section: Biomedical Applications Of Mofsmentioning
confidence: 99%
“…Particularly, the good dispersibility and biocompatibility of NMOFs ensure the biosecurity for in vivo applications. [7] In this review article, we will summarize the recent developments of MOF-based composite materials including the synthesis and functionalization [8][9][10][11][12][13][14][15] and their biomedical applications in the delivery of cargos including drugs, nucleic acids, proteins, and dyes (Table 1), [19,21-23,25-29,31b,d,34-41] bioimaging (Table 2), [43][44][45][47][48][49][50][51][52][53][54] antimicrobial (Table 3), [57,[60][61][62][63][64][65][66][67] biosensing (Table 4), [69][70][71][72][73][75][76][77][78][79][80][81][82][83...…”
Section: Doi: 101002/smll201906846mentioning
confidence: 99%
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“…Reticular framework nanoparticles have been used for a wide variety of sensing applications in diagnostics ranging from metal ions [431] to nucleic acid polymers [432] and all the way to entire organisms such as bacteria. [433] A selection of them will be presented in the following.…”
Section: Nanoparticles As Sensorsmentioning
confidence: 99%
“…The second electrochemical biosensor was described by Shahrokhian and Ranjibar. In this study Differential Pulse Voltammetry (DPV) was utilized to develop a novel aptamer-based diagnostic platform for E. coli O157:H7 using amino-functionalized metalorganic frameworks (MOFs) (Shahrokhian and Ranjbar, 2018). In their design (Figure 2B), the amino-functionalized-metalorganic frameworks (MOFs), whose electrical and morphological properties were enhanced with polyaniline (PANI), served as a nanocomposite to enhance aptamer immobilization onto the glass electrode.…”
Section: Escherichia Colimentioning
confidence: 99%