Aqua‐mediated rapid and benign synthesis of 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one‐appended novel 2‐arylidene indanones of pharmacological interest at ambient temperature

Abstract

In the present investigation, a green aqua‐mediated protocol for the synthesis of novel 2‐arylidene indanone derivatives from 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one was unveiled. The application of water in organic reactions as a solvent is one of the incredible tools of green chemistry as reactions can be carried out under benign conditions minimizing environmental hazard and chemical waste. A library of novel 2‐arylidene indanone derivatives are synthesized in good to excellent yield by utilizing the green potential of water as a solvent. The structures of all novel 2‐arylidene indanone derivatives reported herein are confirmed using Fourier‐transform infrared spectroscopy (FTIR), 1H NMR, 13C NMR, 19F NMR, distortionless enhancement by polarization transfer (DEPT), and High Resolution Mass Spectrometry (HRMS) techniques.

Spectroscopic (FTIR and UV), quantum Chemical, antifungal and antioxidant investigations of (E)‐7‐(4‐(trifluoromethyl)benzylidene)‐1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one: A combined experimental and theoretical study

“…The titled compound was re-synthesized according to our recently reported method. [42] A mixture of 1,2,6,7-tetrahydro-8H-indeno [5,4-b]furan-8-one (1, 8 mmol) and 4-(trifluoromethyl)benzaldehyde (2, 8 mmol) added into a conical flask containing water and NaOH. The mixture was warmed up to boiling and stirred until the formation of the product (monitored by the thin-layer chromatography using 7:3 (n-hexane: ethyl acetate) mobile phase).…”

Synthesis, Characterization and Theoretical Insights into Molecular Properties of 2-(4-fluorophenyl)-4H-chromen-4-one

“…Researchers have been studying flavonoids as oxidative reaction inhibitors and anti-inflammatory agents in recent years [5,6]. They have been shown to have anxiolytic, antiviral, antiprotozoal, anti-microbial, and anti-carcinogenic properties [7][8][9][10][11][12]. Usually chalcones are the precursors used for the synthesis of flavones.…”

Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives

“…With developing need towards greener approaches, the use and modification of traditional methodologies is the need of the present, and in such a circumstance, PEG might be the solvent of higher preference because of its versatile blessings as a green reaction media. Since the arrival of green chemistry, various green chemistry orientated synthetic methods have been progressed so one can synthesize a wide variety of compounds without or less environmental hazard . One such strategy which has pulled brilliant attention of researchers in the organic synthesis using benign reaction media.…”

“…Since the arrival of green chemistry, various green chemistry orientated synthetic methods have been progressed so one can synthesize a wide variety of compounds without or less environmental hazard. [19][20][21][22][23][24][25][26] One such strategy which has pulled brilliant attention of researchers in the organic synthesis using benign reaction media. PEG solvents are perceived to be cheap, easily accessible, recyclable, thermally stable, biologically compatible and non-lethal.…”