Aquafoldmer-Based Aquaporin-like Synthetic Water Channel

Shen, Jie; Ye, Ruijuan; Romanies, Alyssa; Roy, Arundhati; Chen, Feng; Ren, Changliang; Liu, Zhiwei; Zeng, Huaqiang

doi:10.1021/jacs.0c02013

Cited by 88 publications

(106 citation statements)

References 44 publications

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“…3c ). Translocation of water molecules as singly aligned waterwires has been reported in typical natural and synthetic water channels which are capable of salt rejection 9 , 11 – 13 , 35 , 36 . This is because of the confinement of water within channels with window opening sizes smaller than 1 nm.…”

Section: Resultsmentioning

confidence: 99%

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Porous organic cages as synthetic water channels

et al. 2020

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Nature has protein channels (e.g., aquaporins) that preferentially transport water molecules while rejecting even the smallest hydrated ions. Aspirations to create robust synthetic counterparts have led to the development of a few one-dimensional channels. However, replicating the performance of the protein channels in these synthetic water channels remains a challenge. In addition, the dimensionality of the synthetic water channels also imposes engineering difficulties to align them in membranes. Here we show that zero-dimensional porous organic cages (POCs) with nanoscale pores can effectively reject small cations and anions while allowing fast water permeation (ca. 109 water molecules per second) on the same magnitude as that of aquaporins. Water molecules are found to preferentially flow in single-file, branched chains within the POCs. This work widens the choice of water channel morphologies for water desalination applications.

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Section: Resultsmentioning

confidence: 99%

“…Empirically observed, channels with a window opening size of ca. 3 Å (close to that of aquaporins) can effectively exclude hydrated ions 11 – 13 . Unfortunately, this may come at the expense of much lower water permeabilities 12 .…”

Section: Introductionmentioning

confidence: 92%

Porous organic cages as synthetic water channels

et al. 2020

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“…Importantly, the approximately 20 % enlargement in Å‐scale pore volume results in the formation of dynamic, more fluidic pores, which induce a 15‐fold enhancement of water transport. This sheds light on the fastest AWC to date, which is able to translocate water at a rate of ∼3×10 9 H 2 O s −1 channel −1 with a high rejection of NaCl and KCl [25d] …”

Section: Artificial Water Channels: Synthetic Aqpsmentioning

confidence: 78%

“…Importantly, the deviation from the thermodynamically stable, hydrogen‐bonded, strongly confined structures observed within the single‐crystal structures toward more relaxed molecules of supramolecular aggregates, which generate more relaxed and highly permeable water clusters, is one of the most important discoveries that can be considered for the simultaneous improvement of both water permeability and selectivity. Relaxed I‐quartet sponges, [22, 24] aquafoldamers, [25d] or porous organic cages (POCs) [50] as well as confined pillararene networks are representative examples that have been independently reported during the last two years (2018–2020)!…”

Section: Discussionmentioning

confidence: 99%

Artificial Water Channels: Towards Biomimetic Membranes for Desalination

Huang

Vincenzo

et al. 2020

Chemistry A European J

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Natural Aquaporin (AQP) channels are efficient water translocating proteins, rejecting ions. Inspired by this masterpiece of nature, Artificial Water Channels (AWCs) with controlled functional structures, can be potentially used to mimic the AQPs to a certain extent, offering flexible avenues toward biomimetic membranes for water purification. The objective of this paper is to trace the historical development and significant advancements of current reported AWCs. Meanwhile, we attempt to reveal important structural insights and supramolecular self‐assembly principles governing the selective water transport mechanisms, toward innovative AWC‐based biomimetic membranes for desalination.

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“…20 On the other hand, driven by intermolecular forces, bilayerspanning helices are assembled into versatile membrane proteins with N-and C-termini heading towards the cytosol, and these specialized membrane proteins are featured with well-de ned angstrom-scale channels and chemical functionality, 21,22 which synergistically combine size, charge, van der Waals, and other speci c binding interactions to achieve the selective and super-fast transport of target species. 23,24 For example, the AQP within cellular membrane exhibits a high permeability of 3 × 10 9 H 2 O molecules per second per AQP subunit but completely excludes all ionic species; 25 the CO 2 permeability can reach up to 120000 molecules per second per AQP subunit; 26 the potassium permeation rate is ~ 10 8 ions/s with a super high potassium/ sodium ion selectivity of ~ 1000. 2 The elegant structure and unprecedented performances of cellular membranes provide archetypes and grant germane inspirations for the design of highly e cient membranes for sub-angstrom/angstromscale ion or molecule separations.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired nano-ordered liquid membrane for precise molecular separation

Dou¹,

Xu²,

Wang³

et al. 2020

Preprint

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Cellular membranes provide ideal archetypes for molecule or ion separations with sub-angstrom scale precision, which are featured with both extremely high permeability and selectivity due to the well-defined membrane protein channels. However, the development of bioinspired membranes with artificial channels for sub-angstrom scale ethylene/ethane (0.416 nm / 0.443 nm) separation remains an uncharted territory and a significant challenge. Herein, a bioinspired nano-ordered liquid membrane is constructed by a facile ion/molecule self-assembly strategy for highly efficient ethylene/ethane separation, which mimics the structure of cellular membrane elegantly and possesses plenty of three-dimensional (3D) nanochannels. The elaborate regulation of non-covalent interactions by optimizing the ion/molecule compositions within membrane confers the nano-ordered liquid structure with interpenetrating and bi-continuous apolar domains and polar domains, which results in the formation of regular carrier wires and enormous 3D interconnected ethylene transport nanochannels. By virtue of these 3D nanochannels, the bioinspired nano-ordered liquid membrane manifests simultaneously super-high selectivity, excellent permeance and long-term stability, which exceeds previously reported ethylene/ethane separation membranes. This methodology in this work for construction of bioinspired membrane with tunable 3D nanochannels through ion/molecule self-assembly will enlighten the design and development of high-performance separation membranes for angstrom/sub-angstrom scale ion or molecule separations.

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Aquafoldmer-Based Aquaporin-like Synthetic Water Channel

Cited by 88 publications

References 44 publications

Porous organic cages as synthetic water channels

Porous organic cages as synthetic water channels

Artificial Water Channels: Towards Biomimetic Membranes for Desalination

Bioinspired nano-ordered liquid membrane for precise molecular separation

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