Aquaporin‐1 in breast cancer

Traberg-Nyborg, Laura; Login, Frédéric H.; Edamana, Sarannya; Tramm, Trine; Borgquist, Signe; Nejsum, Lene N.

doi:10.1111/apm.13192

Cited by 16 publications

(7 citation statements)

References 66 publications

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“…Bystrup [ 107 ] considers that understanding the underlying molecular mechanisms of how AQP5 contributes to cancer development and progression is crucial for the potential use of AQP5 as a prognostic biomarker and for the development of targeted intervention strategies for the treatment of breast cancer patients. A similar observation was presented by Traberg-Nyborg [ 108 ] on aquaporin-1 and by Milkovic [ 109 ] on aquaporins 3 and 5. In addition to the above-mentioned statement, a study by Moosavi [ 110 ] found that overexpression of AQP1, AQP3, and AQP5 is inextricably linked to carcinogenesis, metastasis, decreased survival rate, lymph node metastasis, a worse prognosis, and cellular migration and that furthermore, cancer therapies associated with these markers suggest AQP decreases during treatment.…”

Section: Resultssupporting

confidence: 87%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: (a) breast/chest radiation exposure, (b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and (c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and (d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. Randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.

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Section: Resultssupporting

confidence: 87%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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“…Excessive RONS absorbed by AQPs can induce nitro-oxidative stress within the cell, leading to damage to intracellular biomolecules and signaling pathways, ultimately resulting in cell death [ 212 ]. AQPs are often overexpressed in various types of cancer cells, including breast [ 213 , 214 ], lung [ 215 ], ovarian [ 216 , 217 ], and colorectal cancer [ 218 , 219 ]. This overexpression allows AQPs to increase the intracellular RONS level in cancer cells compared to normal cells, making CAP more detrimental to cancer cells than to normal cells [ 220 , 221 ].…”

Section: Non-reactive MD Simulations Of Proteinsmentioning

confidence: 99%

Effects of Nitro-Oxidative Stress on Biomolecules: Part 1—Non-Reactive Molecular Dynamics Simulations

Ghasemitarei,

Ghorbi,

Yusupov

et al. 2023

Biomolecules

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Plasma medicine, or the biomedical application of cold atmospheric plasma (CAP), is an expanding field within plasma research. CAP has demonstrated remarkable versatility in diverse biological applications, including cancer treatment, wound healing, microorganism inactivation, and skin disease therapy. However, the precise mechanisms underlying the effects of CAP remain incompletely understood. The therapeutic effects of CAP are largely attributed to the generation of reactive oxygen and nitrogen species (RONS), which play a crucial role in the biological responses induced by CAP. Specifically, RONS produced during CAP treatment have the ability to chemically modify cell membranes and membrane proteins, causing nitro-oxidative stress, thereby leading to changes in membrane permeability and disruption of cellular processes. To gain atomic-level insights into these interactions, non-reactive molecular dynamics (MD) simulations have emerged as a valuable tool. These simulations facilitate the examination of larger-scale system dynamics, including protein-protein and protein-membrane interactions. In this comprehensive review, we focus on the applications of non-reactive MD simulations in studying the effects of CAP on cellular components and interactions at the atomic level, providing a detailed overview of the potential of CAP in medicine. We also review the results of other MD studies that are not related to plasma medicine but explore the effects of nitro-oxidative stress on cellular components and are therefore important for a broader understanding of the underlying processes.

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“…Leptin-upregulated AQP1 protein expression was inhibited by treatment with OB-R BP (Figure 4E,F) and AG490 (Figure 4G,H), indicating that AQP1 is upregulated by the leptin/Ob-R/STAT3 pathway. High AQP1 expression affects the cellular processes including cell migration, proliferation, and angiogenesis [48]. Overexpression of AQP1 using the activation plasmid (Figure 5A,B) effectively increased VM (Figure 5C,D) and upregulated the expression of VM-related proteins (Figure 5E,F), indicating that AQP1 itself could induce VM.…”

Section: Discussionmentioning

confidence: 98%

Leptin Promotes Vasculogenic Mimicry in Breast Cancer Cells by Regulating Aquaporin-1

Han,

Lee

2024

IJMS

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Leptin is an obesity-related hormone that plays an important role in breast cancer progression. Vasculogenic mimicry (VM) refers to the formation of vascular channels lined by tumor cells. This study aimed to investigate the relationship between leptin and VM in human breast cancer cells. VM was measured by a 3D culture assay. Signal transducers and activators of transcription 3 (STAT3) signaling, aquaporin-1 (AQP1), and the expression of VM-related proteins, including vascular endothelial cadherin (VE-cadherin), twist, matrix metalloproteinase-2 (MMP-2), and laminin subunit 5 gamma-2 (LAMC2), were examined by Western blot. AQP1 mRNA was analyzed by a reverse transcriptase-polymerase chain reaction (RT-PCR). Leptin increased VM and upregulated phospho-STAT3, VE-cadherin, twist, MMP-2, and LAMC2. These effects were inhibited by the leptin receptor-blocking peptide, Ob-R BP, and the STAT3 inhibitor, AG490. A positive correlation between leptin and AQP1 mRNA was observed and was confirmed by RT-PCR. Leptin upregulated AQP1 expression, which was blocked by Ob-R BP and AG490. AQP1 overexpression increased VM and the expression of VM-related proteins. AQP1 silencing inhibited leptin-induced VM and the expression of VM-related proteins. Thus, these results showed that leptin facilitates VM in breast cancer cells via the Ob-R/STAT3 pathway and that AQP1 is a key mediator in leptin-induced VM.

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Aquaporin‐1 in breast cancer

Cited by 16 publications

References 66 publications

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

Effects of Nitro-Oxidative Stress on Biomolecules: Part 1—Non-Reactive Molecular Dynamics Simulations

Leptin Promotes Vasculogenic Mimicry in Breast Cancer Cells by Regulating Aquaporin-1

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