Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases

Olesen, Emma Tina Bisgaard; Fenton, Robert A.

doi:10.1038/s41581-021-00447-x

Cited by 51 publications

(49 citation statements)

References 152 publications

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“…AQP8 is expressed in the inner membrane of mitochondria and involved in H 2 O 2 transport linked with the accumulation of reactive oxygen species (ROS) [52], revealing an unexpected breadth of physiologically important roles for AQPs across phyla [13,56] and highlighting many gaps in our knowledge that are yet to be addressed. Recent perspectives have provided comprehensive synopses of AQP-related diseases beyond the scope of this review [57][58][59][60][61][62][63][64][65][66][67][68].…”

Section: Aqp Permeabilities: An Expanding Repertoirementioning

confidence: 99%

Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

Wagner

Unger

Salman

et al. 2022

IJMS

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The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders.

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Section: Aqp Permeabilities: An Expanding Repertoirementioning

confidence: 99%

Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

Wagner

Unger

Salman

et al. 2022

IJMS

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“…Interestingly, NaCl is known to increase Aqp2 independent of exogenous vasopressin, but the contribution of endogenous vasopressin had never been studied (5, 22). We found that V2R was activated in-vitro by endogenous vasopressin in response to hypertonic stress.…”

Section: Discussionmentioning

confidence: 99%

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

Arroyo

Terker

Zuchowski

et al. 2022

Preprint

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Vasopressin has traditionally been thought to be produced by the neurohypophyseal system and then released into the circulation where it regulates water homeostasis. The syndrome of inappropriate secretion of anti-diuretic hormone (vasopressin) made us question if vasopressin could be produced outside of the brain and whether the kidney could be a source of vasopressin. We found that mouse and human kidneys expressed vasopressin mRNA. Using an antibody that detects the pre-pro-vasopressin, we found that immunoreactive pre-pro-vasopressin protein is found in mouse and human kidneys. Moreover, we found that murine collecting duct cells make biologically active vasopressin which increases in response to NaCl mediated hypertonicity, and that water restriction increases the abundance of kidney-derived vasopressin mRNA and protein expression in mouse kidneys. Thus, we provide evidence of biologically active production of kidney-derived vasopressin in kidney tubular epithelial cells.

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“…Relocalisation of AQP2 to the apical membrane of kidney collecting duct cells in response to the anti-diuretic hormone, arginine vasopression, was the first discovered example of an AQP regulated by subcellular relocalisation [43] , [44] , and remains the most well characterised. AQP2 relocalisation has been extensively reviewed elsewhere [45] , [46] , [47] , so we intend to give the reader only a brief overview.…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanisms governing aquaporin relocalisation

Markou

Unger

Abir-Awan

et al. 2022

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Aquaporin 2 regulation: implications for water balance and polycystic kidney diseases

Cited by 51 publications

References 152 publications

Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease

Kidney collecting duct cells make vasopressin in response to NaCl induced hypertonicity

Molecular mechanisms governing aquaporin relocalisation

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