Aquaporins in health and disease

Magouliotis, Dimitrios; Tasiopoulou, Vasiliki S.; Svokos, Alexis; Svokos, Konstantina

doi:10.1016/bs.acc.2020.02.005

Cited by 10 publications

(7 citation statements)

References 139 publications

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“…However, different kidney diseases, such as nephrogenic diabetes insipidus (NDI), autosomal dominant polycystic kidney disease (ADPKD), and acute kidney injury (AKI), would be caused by the occurrence of mutations or deletions of AQPs. Nevertheless, it is different from other diseases related to AQPs, for instance, the high expression of AQPs will aggravate the edema of astrocytoma and eventually lead to an increase in mortality; the severity of chronic obstructive pulmonary disease (COPD) and asthma is related to the high expression of AQPs [9,30,31].…”

Section: Plos Onementioning

confidence: 99%

“…AQP12 is divided into two subtypes called AQP12A and AQP12B [8]. By adjusting cell permeability, mediating glycerol translocation, taking part in some specific signaling pathways and other biological functions, AQPs are not only expressed in various epithelial and nonepithelial tissues for regulating rapid water movement but also actively implicate and regulate a variety of cancers [9]. For instance, previous studies had identified the expression and prognostic value of AQPs in pancreatic cancer and gastric cancer [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma

et al. 2022

PLoS ONE

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Aquaporins (AQPs) are a kind of transmembrane proteins that exist in various organs of the human body. AQPs play an important role in regulating water transport, lipid metabolism and glycolysis of cells. Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the kidney, and the prognosis is worse than other types of renal cell cancer (RCC). The impact of AQPs on the prognosis of ccRCC and the potential relationship between AQPs and the occurrence and development of ccRCC are demanded to be investigated. In this study, we first explored the expression pattern of AQPs by using Oncomine, UALCAN, and HPA databases. Secondly, we constructed protein-protein interaction (PPI) network and performed function enrichment analysis through STRING, GeneMANIA, and Metascape. Then a comprehensive analysis of the genetic mutant frequency of AQPs in ccRCC was carried out using the cBioPortal database. In addition, we also analyzed the main enriched biological functions of AQPs and the correlation with seven main immune cells. Finally, we confirmed the prognostic value of AQPs throughGEPIA and Cox regression analysis. We found that the mRNA expression levels of AQP0/8/9/10 were up-regulated in patients with ccRCC, while those of AQP1/2/3/4/5/6/7/11 showed the opposite. Among them, the expression differences of AQP1/2/3/4/5/6/7/8/9/11 were statistically significant. The differences in protein expression levels of AQP1/2/3/4/5/6 in ccRCC and normal renal tissues were consistent with the change trends of mRNA. The biological functions of AQPs were mainly concentrated in water transport, homeostasis maintenance, glycerol transport, and intracellular movement of sugar transporters. The high mRNA expression levels of AQP0/8/9 were significantly correlated with worse overall survival (OS), while those of AQP1/4/7 were correlated with better OS. AQP0/1/4/9 were prognostic-related factors, and AQP1/9 were independent prognostic factors. In general, this research has investigated the values of AQPs in ccRCC, which could become new survival markers for ccRCC targeted therapy.

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Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma

et al. 2022

PLoS ONE

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“…Future Trends and Potential Therapeutic Targets in Breast Cancer 3.6.1. Aquaporins Aquaporins (AQPs) are membrane channels that belong to the large family of major intrinsic proteins (MIPs), of which there are thirteen classes with tissue-specific distributions in humans, as summed up by Khan [103] and Magouliotis [104]. As important physiological modulators of water and solute homeostasis, mutations and dysfunctions in aquaporins have been linked to pathologies in all major organs.…”

Section: Prognosismentioning

confidence: 99%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

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Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: (a) breast/chest radiation exposure, (b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and (c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and (d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. Randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.

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“…From a clinical point of view, it was reported that AQP3 and AQP5 are involved in the pathophysiology of esophageal, gastric, pancreatic, hepatocellular, colorectal, breast and cervical cancers [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. In a recent metanalysis, increased production of AQP1and AQP5 was correlated with reduced survival rate, bad prognosis, and lymph node diffusion; remarkably, tumor chemotherapy caused AQP decrease [ 70 , 71 , 72 , 73 ].…”

Section: Aquaporins and Cancermentioning

confidence: 99%

Critical Role of Aquaporins in Cancer: Focus on Hematological Malignancies

Allegra

Cicero

Mirabile

et al. 2022

Cancers

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Aquaporins are transmembrane molecules regulating the transfer of water and other compounds such as ions, glycerol, urea, and hydrogen peroxide. Their alteration has been reported in several conditions such as cancer. Tumor progression might be enhanced by aquaporins in modifying tumor angiogenesis, cell volume adaptation, proteases activity, cell–matrix adhesions, actin cytoskeleton, epithelial–mesenchymal transitions, and acting on several signaling pathways facilitating cancer progression. Close connections have also been identified between the aquaporins and hematological malignancies. However, it is difficult to identify a unique action exerted by aquaporins in different hemopathies, and each aquaporin has specific effects that vary according to the class of aquaporin examined and to the different neoplastic cells. However, the expression of aquaporins is altered in cell cultures and in patients with acute and chronic myeloid leukemia, in lymphoproliferative diseases and in multiple myeloma, and the different expression of aquaporins seems to be able to influence the efficacy of treatment and could have a prognostic significance, as greater expression of aquaporins is correlated to improved overall survival in leukemia patients. Finally, we assessed the possibility that modifying the aquaporin expression using aquaporin-targeting regulators, specific monoclonal antibodies, and even aquaporin gene transfer could represent an effective therapy of hematological malignancies.

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Aquaporins in health and disease

Cited by 10 publications

References 139 publications

Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma

Abnormal expression and the significant prognostic value of aquaporins in clear cell renal cell carcinoma

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

Critical Role of Aquaporins in Cancer: Focus on Hematological Malignancies

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