Aquaporins, Vasopressin, and Aging: Current Perspectives

Tamma, Grazia; Goswami, Nandu; Reichmuth, Johannes; Santo, Natale G. De; Valenti, Giovanna

doi:10.1210/en.2014-1812

Cited by 47 publications

(40 citation statements)

References 125 publications

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“…In this study, the strong negative association between age and NaC was also observed in patients not treated with diuretics [19]. It is therefore possible that ageing per se causes alterations of sodium and water homeostasis either peripherally, e.g., kidney, or centrally, e.g., osmotic receptors in the hypothalamus [20]. Chronic kidney disease, hence a reduced eGFR, is associated with an increased incidence of either hypo- or hypernatremia [21].…”

Section: Discussionmentioning

confidence: 64%

Patterns of Drug Use and Serum Sodium Concentrations in Older Hospitalized Patients: A Latent Class Analysis Approach

Woodman

Wood

Kunnel

et al. 2016

Drugs - Real World Outcomes

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BackgroundSeveral drugs may lower serum sodium concentrations (NaC) in older patients. However, distinguishing their individual effects is particularly difficult in this population because of the high prevalence of polypharmacy and disease states that are per se associated with hyponatremia.ObjectivesOur objective was to identify specific patterns of medication use in older hospitalized patients and determine whether these patterns were associated with serum NaC.MethodsWe collected clinical and demographic data, pre-admission drugs, Drug Burden Index (DBI) score, and average NaC during hospitalization in a consecutive series of older medical patients (n = 101, mean ± standard deviation [SD] age 87 ± 6 years). We used latent class analysis (LCA) to identify specific patterns of drug use and multivariate regression to determine the associations between 14 separate drug classes, identified patterns of drug use, and NaC.ResultsLCA revealed three patterns: lower overall drug use (class 1), anticoagulant use and higher drug use (class 2), and antiplatelet use (class 3). Mean (±SD) DBI score in each class was 2.7 ± 1.3, 3.3 ± 1.6, and 2.4 ± 1.5, respectively (p = 0.04). Mean (± SD) NaC in classes 1, 2, and 3 were 140.6 ± 6.8, 138.7 ± 5.3, and 136.5 ± 4.7 mmol/l, respectively (p = 0.006). After adjustment for age, sex, Charlson Comorbidity Index score, estimated glomerular filtration rate (eGFR), DBI score, and digoxin use, mean NaC in class 2 and class 3 was significantly lower than in class 1 (−3.9 mmol/l; 95% confidence interval [CI] −7.1 to −0.8, p = 0.01 and −5.2 mmol/l; 95% CI −7.9 to −2.5, p < 0.001, respectively). Mean serum NaC was not significantly associated with any of the 14 individually assessed drug classes. In addition to latent class, increasing age and higher eGFR were also independently associated with lower serum NaC (p = 0.002 and p = 0.03, respectively).ConclusionLCA enabled us to identify patterns of drug use associated with lower serum NaC in older inpatients. Our results suggest that older patients using antiplatelets or anticoagulants are especially at risk of lower serum NaC.

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Section: Discussionmentioning

confidence: 64%

Patterns of Drug Use and Serum Sodium Concentrations in Older Hospitalized Patients: A Latent Class Analysis Approach

Woodman

Wood

Kunnel

et al. 2016

Drugs - Real World Outcomes

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“…In addition, hyponatremia is known to be associated with osteoporosis and increased fracture risk. Increased arginine vasopressin (AVP) levels, which are frequently observed in the elderly, can cause water retention and hyponatremia, often stimulating calcium liberation from bones, leading to osteoporosis and increased fracture risk [14]. AQP9 expression has been shown to increase under normal physiological conditions during osteoclast biogenesis [9]; this has been reported to be important in the pathophysiology of various diseases that involve bone resorption [30].…”

Section: Discussionmentioning

confidence: 99%

“…Evaluation of the immunohistochemical labeling was performed using H-SCORE analyses, as previously described [14]. The intensity of AQP1 and AQP3 immunoreactivity was semi-quantitatively evaluated using the following intensity categories: 0 (no staining), 1+ (weak but detectable staining), 2+ (moderate or distinct staining), and 3+ (intense staining).…”

Section: Evaluation Of the Immunohistochemistrymentioning

confidence: 99%

Investigation of Age-Related Changes in Expression of Aquaporin-1 and Aquaporin-3 in Rat Bone

Sapmaz¹

2016

Ann Clin Anal Med

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ÖzetAmaç: Aquaporinler su ve iyon transportu sağlayan membran kanal proteinleridir. Yaşlanma ile dokulardaki aquaporinlerin miktarı değişmektedir. Aquaporin-1 (AQP1) ve aquaporin-3 (AQP3)'ün kıkırdak dokuda yaşlanma ile azaldığı gösterilmiştir. Ancak kemik dokuda yaşlanma ile aquaporinlerin miktarında değişim gösterilmemiştir. Bu çalışmada genç ve yaşlı hayvanların kemik dokularında AQP1, AQP3 ve tip I kollajen ekspresyonlarının immünohis-tokimyasal olarak araştırılması amaçlandı. Gereç ve Yöntem: Bu çalışmada 14 adet Wistar Albino cinsi sıçan kullanıldı. Grup I (n=7) iki aylık genç sıçan-lardan, Grup II (n=7) onsekiz aylık yaşlı sıçanlardan oluşmaktaydı. Kemik dokusu (femur) histopatolojik ve immunohistokimyasal değerlendirme için alın-dı. Rutin histolojik prosedürün ardından parafine gömülen dokulardan 4-5 µm kalınlığında kesitler alındı. İmmunohistokimyasal olarak AQP1, AQP3 ve tip I kollajen boyama ayrıca Hematoksilen-eozin boyama yapıldı. Bulgular: Genç ve yaşlı sıçanlarda immünohistokimyasal olarak AQP1, AQP3 ve tip I kollajen ekspresyonu gösterildi. Yaşlanma ile AQP1, AQP3 ve tip I kollajen miktarında azalma olduğu gözlendi. Tartışma: AQP1 ve AQP3 mik tarındaki azalmanın kemik dokuda yaşa bağlı değişikliklerle ilgili olabilece ği kanaatindeyiz. Anahtar KelimelerSıçan; Kemik Dokusu; Yaşlanma; Aquaporin 1; Aquaporin 3 Özet Aim: Aquaporins are membrane channel proteins that transport water and ions. The amount of aquaporins in tissue changes with age. The amount of aquaporin-1 (AQP1) and aquaporin-3 (AQP3) is considered to decrease in cartilage tissue with age. However, no age-related change has been reported regarding the amount of aquaporins in bone tissue. In this study, our aim was to examine expressions of AQP1, AQP3, and type I collagen immunohistochemically in the bone tissues of young and old rats. Material and Method: Fourteen Wistar Albino rats were included in this study. Group I (n=7) consisted of young rats that were two months old, while Group II (n=7) consisted of old rats that were eighteen months old. Bone tissue (femur) was dissected and examined histopathologically and immunohistochemically. After routine histological procedure, sections at 4-5 µm thickness were obtained from tissues embedded in paraffin. Sections were stained immunohistochemically for AQP1, AQP3, and type I collagen as well as with hematoxylin-eosin. Results: Immunohistochemically, expressions of AQP1, AQP3, and type I collagen were demonstrated in both young and old rats. AQP1, AQP3, and type I collagen amounts were found to decrease with aging. Discussion: Our findings suggest that reduced amounts of AQP1 and AQP3 may be related to agerelated changes in bone tissue.

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“…Furthermore, decreased renin-aldosterone activity exists in aged individuals leading to abnormal movement of solutes (56). The final result of these abnormalities is higher sensitivity to water overload or dehydration, and increased risk for developing hypo-or hypernatremia.…”

Section: Aging and Water Balancementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

Diamanti-Kandarakis

Dattilo²,

Macut

et al. 2017

European Journal of Endocrinology

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Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic-pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.

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Aquaporins, Vasopressin, and Aging: Current Perspectives

Cited by 47 publications

References 125 publications

Patterns of Drug Use and Serum Sodium Concentrations in Older Hospitalized Patients: A Latent Class Analysis Approach

Patterns of Drug Use and Serum Sodium Concentrations in Older Hospitalized Patients: A Latent Class Analysis Approach

Investigation of Age-Related Changes in Expression of Aquaporin-1 and Aquaporin-3 in Rat Bone

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

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