Aquaretic inhibits renal cancer proliferation: Role of vasopressin receptor-2 (V2-R)

Bolignano, Davide; Medici, Maria Antonietta; Coppolino, Giuseppe; Sciortino, Maria Teresa; Marino-Merlo, Francesca; Campo, Susanna; Donato, Valentina; Venuti, Assunta; Sturiale, Alessio; Zaccaria, Daniela; Buemi, Antoine; Lacquaniti, Antonio; Buemi, Michele

doi:10.1016/j.urolonc.2008.12.014

Cited by 20 publications

(21 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, this growth was completely avoided by the preventive addition of the V2-R antagonist (Satavaptan). 19 This study thus showed that aquaretic drugs might be used not only to prevent hyponatremia caused by chemotherapy or other drugs but also to inhibit proliferation of several cancers.…”

Section: Disorders Of Hydroelectrolitic Balance During Neoplasiamentioning

confidence: 93%

Nephro-oncology: a link in evolution

et al. 2015

Self Cite

View full text Add to dashboard Cite

A multidisciplinary approach represents the best method to interact with patients. Neoplastic and renal diseases are closely related to each other because of an increased risk of cancer among individuals with end-stage renal disease and because of the high prevalence of renal failure in cancer patients. Physicians should be able to know how to prevent and treat the possible complications which may appear during the course of neoplastic disease that may lead to kidney damage such as the Acute Tumor Lysis Syndrome, disorders of hydroelectrolitic balance, metabolic alterations in the calcium-phosphorus, anemia, interstitial and glomerular impairment due to chemotherapy. It is very important to know patients' renal function and directly monitor it, before and during treatment, using formulas for estimating glomerular filtration rate (GFR) and above all, specific biomarkers are more early and sensitive than the increase of creatinine, like neutrophil gelatinase-associated lipocalin. Additionally, physician should consider that alteration of GFR or substitutive renal treatments severely influence dosage of tumor markers and it could lead to wrong diagnosis of cancer. The aim of this article is to provide a review of problems related to cancer relevant in the development of renal failure and try to define the best therapeutic strategies to cope with possible kidney imbalances induced by cancer or its treatment.

show abstract

Section: Disorders Of Hydroelectrolitic Balance During Neoplasiamentioning

confidence: 93%

Nephro-oncology: a link in evolution

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…A growing body of studies have suggested that vasopressin is involved in cell growth and proliferative mechanisms in different types of carcinomas including prostatic, testicular, ovarian cancer, pancreatic cancers, colon, nasopharyngeal, kidney and gastrointestinal cancers (North, 2000;Bolignano et al, 2010;Khegai et al, 2014;North et al, 2014). It has been suggested that AVS exercises multifaceted effects on tumor growth and metabolism via its receptors, including the V2-R, which have been found on cell surfaces of most cancers where AVS is expressed (North, 2000;Treschan et al, 2006).…”

Section: Electrolyte Dysregulation and Hallmarks Of Cancermentioning

confidence: 99%

Health effects of desalinated water: Role of electrolyte disturbance in cancer development

Nriagu

Darroudi²,

Shomar

2016

Environmental Research

View full text Add to dashboard Cite

“…Moreover, AVP interacts with hormones and the components of certain regulatory pathways, and its central effects may influence behavior [19]. The three AVP receptors V1a-R, V1b-R, and V2-R are expressed on the surface of pulmonary, pancreatic, and breast cancer cells [34]. An additional study found that small cell lung cancer and breast cancer express the vasopressin gene and an abnormal form of the V2 receptor in addition to the three normal receptors [35].…”

Section: Avp and Its Diverse Effects On Carcinogenesismentioning

confidence: 99%

“…AVP acts as the primary controller of water homeostasis by regulating water retention and diuresis [20]. Binding of AVP to V2 receptors induces production of the membrane protein aquaporin 2 (AQP2) [34], which is expressed by cells of the renal collecting ducts and most other cell types [36]. When AVP binds to AQP2, water is transported through large channels in cell membranes that were previously unavailable and causes the absorption of abnormally high volumes of water [35].…”

Section: Avp and Its Diverse Effects On Carcinogenesismentioning

confidence: 99%

“…Furthermore, overproduction of AVP and its receptors influences tumor growth and metabolism, and AVP may act as an autocrine growth factor in some cancers [31,32,34]. The following list summarizes how the synergy of high levels of ROS and AVP production and secretion maintains a balance among dysregulated proliferation, cell cycle arrest, apoptosis, and genomic instability.…”

Section: Excessive Ros and Avp Synergize To Contribute To Oncogenesismentioning

confidence: 99%

See 1 more Smart Citation

The Altered Water System: Excess Levels of Free Radicals Contribute to Carcinogenesis by Altering Arginine Vasopressin Production and Secretion and Promoting Dysregulated Water Homeostasis in Concert with Other Factors

Beutler

Strand

2014

Physiology Journal

View full text Add to dashboard Cite

A large body of evidence accumulated during the last decade has revealed diverse roles of dysregulated water homeostasis in tumorigenesis. In particular, many tumors hypersecrete arginine vasopressin (AVP) causing hypoosmolar conditions associated with different cancers. Excess levels of free radicals and nonosmotic stimuli may act as signals in water homeostasis and induce the production and secretion of AVP. Hypoosmolar conditions cause alterations in the expression of many genes. Other alterations in hydration patterns may induce mutations and increase the levels of protein kinases to contribute to oncogenesis. Furthermore, AVP regulates the hypothalamic-pituitary-adrenal axis and angiogenesis, and its overproduction may contribute to tumor growth and metabolism. This review article describes a mechanism by which oxygen radical species and other free radicals act as signaling molecules that, in concert with increased AVP production and secretion, pleiotropically affect tumor growth and metabolism, resulting in dysregulated proliferation, cell cycle arrest, apoptosis, and genomic instability.

show abstract

Aquaretic inhibits renal cancer proliferation: Role of vasopressin receptor-2 (V2-R)

Cited by 20 publications

References 22 publications

Nephro-oncology: a link in evolution

Nephro-oncology: a link in evolution

Health effects of desalinated water: Role of electrolyte disturbance in cancer development

The Altered Water System: Excess Levels of Free Radicals Contribute to Carcinogenesis by Altering Arginine Vasopressin Production and Secretion and Promoting Dysregulated Water Homeostasis in Concert with Other Factors

Contact Info

Product

Resources

About