Aquasomes: A Nanoparticulate Drug Carrier System

Abstract

Nanotechnology has emerged fields of biomedical research in the last few decades the presents context is an attempt to present the brief information about nanobiotechnological applications.Aquasomes are one of the most recently developed delivery system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Aquasomes are spherical in shape with 60-300 nm particles size. Aquasomes are nanoparticulate carrier system but instead of being simple nanoparticles these are three layered self assembled structures, comprised of a solid core coated with oligomeric film to which biochemically active molecules are adsorbed with or without modification. These structures are self assembled by non covalent and ionic bonds. The solid core provides the structural stability, while the carbohydrate coating protects against dehydration and stabilizes the biochemically active molecules. This article reviews the principles of self assembly, strategies used in chemical synthesis, methods of preparation, characterization and application of Aquasomes.

Aquasomes: an updated review

“…Method/Composition of Preparation of Aquasomes [14,4] In principle, an inorganic core is created, which is subsequently covered with Lactose to generate a polyhydroxylated core, which is then filled with model pharmaceutical. Aquasomes are prepared in three phases based on the self-assembly idea.…”

“…Nanobiopharmaceutics entails the administration of biopharmaceutical products using various biomaterials [2]. Aquasomes, which were first developed by NirKossovsky [3], are the most recently developed drug delivery system for therapeutics because they have the ability to deliver active molecules such as proteins, peptides, hormones, antigens, genes, and drugs of various categories to specific sites [4]. Kossovsky proposed a method for creating nanoparticles containing Aquasomes, which have a particle size (less than 1000 nm) that is suited for parenteral delivery since it prevents bloodstream capillary constriction.…”