Aquatic Hypoxia Is a Teratogen and Affects Fish Embryonic Development

Shang, E.; Wu, Rudolf S.S.

doi:10.1021/es0496423

Cited by 203 publications

(123 citation statements)

References 28 publications

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“…A recent study found that hypoxia can be an endocrine disruptor and teratogen in fish (Wu et al 2003, Shang & Wu 2004. It would be instructive to investigate whether low oxygen levels could also cause disruption of reproductive and growth hormones (e.g.…”

Section: Discussionmentioning

confidence: 99%

Bioenergetics, growth and reproduction of amphipods are affected by moderately low oxygen regimes

Wu¹,

Or²

2005

Mar. Ecol. Prog. Ser.

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Section: Discussionmentioning

confidence: 99%

Bioenergetics, growth and reproduction of amphipods are affected by moderately low oxygen regimes

Wu¹,

Or²

2005

Mar. Ecol. Prog. Ser.

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“…To understand further how embryo development may be affected by sperm selection during the first 24 hpf, we examined the occurrence of apoptotic cells (15), which are a potential indicator of embryonic fitness (16,17), in embryos at the age of 8 hpf (experiment 4) ( Fig. 2 A and B).…”

Section: Significancementioning

confidence: 99%

Haploid selection within a single ejaculate increases offspring fitness

Alavioon

Hotzy

Nakhro

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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An inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have farreaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring. Using the zebrafish Danio rerio, we show that selection on phenotypic variation among intact fertile sperm within an ejaculate affects offspring fitness. Longer-lived sperm sired embryos with increased survival and a reduced number of apoptotic cells, and adult male offspring exhibited higher fitness. The effect on embryo viability was carried over into the second generation without further selection and was equally strong in both sexes. Sperm pools selected by motile phenotypes differed genetically at numerous sites throughout the genome. Our findings clearly link within-ejaculate variation in sperm phenotype to offspring fitness and sperm genotype in a vertebrate and have major implications for adaptive evolution.

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“…At the cellular level, hypoxia has been shown to be an endocrine disruptor, impairing the ability for fish to reproduce, as well as a teratogen, leading to malformed embryos (Wu and others 2003;Shang and Wu 2004). Although many laboratory studies indicate decreased consumption and growth as a result of hypoxia exposure, some indicate that these effects may not be seen in the wild because fish have the ability to detect and avoid hypoxia (Burleson and others 2001;Roberts and others 2011;Vanderplancke and others 2015).…”

Section: Introductionmentioning

confidence: 99%

From Bacteria to Fish: Ecological Consequences of Seasonal Hypoxia in a Great Lakes Estuary

Weinke

Biddanda

2017

Ecosystems

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The occurrence of bottom-water hypoxia is increasing in bodies of water around the world. Hypoxia is of concern due to the way it negatively impacts lakes and estuaries at the whole ecosystem level. During 2015, we examined the influence of hypoxia on the Muskegon Lake ecosystem by collecting surface-and bottom-water nutrient samples, bacterial abundance counts, benthic fish community information, and performing profiles of chlorophyll and phycocyanin as proxies for phytoplankton and cyanobacterial growth, respectively. Several significant changes occurred in the bottom waters of the Muskegon Lake ecosystem as a result of hypoxia. Lake-wide concentrations of soluble reactive phosphorus (SRP) and total phosphorus increased with decreasing dissolved oxygen (DO). Bacterial abundance was significantly lower when DO was less than 2.2 mg L -1 . Whereas there were no drastic changes in surface chlorophyll a concentration through the season, phycocyanin increased threefold during and following a series of major wind-mixing events. Phycocyanin remained elevated for over 1.5 months despite several strong wind events, suggesting that high SRP concentrations in the bottom waters may have mixed into the surface waters, sustaining the bloom. The fish assemblage in the hypolimnion also changed in association with hypoxia. Overall fish abundance, number of species, and maximum length all decreased in catch as a function of bottom DO concentrations. The link between hypoxia and wind events appears to serve as a positive feedback loop by continuing internal loading and cyanobacterial blooms in the lake, while simultaneously eroding habitat quality for benthic fish.

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Aquatic Hypoxia Is a Teratogen and Affects Fish Embryonic Development

Cited by 203 publications

References 28 publications

Bioenergetics, growth and reproduction of amphipods are affected by moderately low oxygen regimes

Bioenergetics, growth and reproduction of amphipods are affected by moderately low oxygen regimes

Haploid selection within a single ejaculate increases offspring fitness

From Bacteria to Fish: Ecological Consequences of Seasonal Hypoxia in a Great Lakes Estuary

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