Rapidly changing climate is disrupting the High Arctic's water systems. As tracers of hydrological processes, stable water isotopes can be used for high quality monitoring of Arctic waters to better reconstruct past changes and assess future environmental threats. However, logistical challenges typically limit the length and scope of isotopic monitoring in High Arctic landscapes. Here, we present a comprehensive isotopic survey of 535 water samples taken in 2018 and 2019 of the lakes and other surface waters of the periglacial Pituffik Peninsula in far northwest Greenland. The δ18O, δ2H, and deuterium‐excess values of these samples, representing 196 unique sites, grant unprecedented insight into the environmental drivers of the regional hydrology and water isotopic variability. We find that the spatial variability of lake water isotopes can best be explained through evaporation and the hydrological ability of a lake to replace evaporative water losses with precipitation and snowmelt. Temporally, summer‐long evaporation can drive lake water isotopes beyond the isotopic range observed in precipitation, and wide interannual changes in lake water isotopes reflect annual weather differences that influenced evaporation. Following this, water isotope samples taken at individual times or sites in similar periglacial landscapes may have limited regional representativeness, and increasing the spatiotemporal extent of isotopic sampling is critical to producing accurate and informative High Arctic paleoclimate reconstructions. Overall, our survey highlights the diversity of isotopic compositions in Pituffik surface waters, and our complete isotopic and geospatial database provides a strong foundation for future researchers to study hydrological changes at Pituffik and across the Arctic.
