Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration

Galin, Miles A.; Nano, Hugo D.; Davidson, Richard

doi:10.1001/archopht.1961.01840020807010

Cited by 18 publications

(4 citation statements)

References 7 publications

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“…The amount of urea in the aqueous humor is known to increase in proportion to blood urea, and oxidized glutathione is increased in the aqueous humor in patients with renal failure, which is described as urea, and may be toxic to the corneal endothelium. [ 39 , 40 ] However, since our sample size was small, additional research and analyses are needed.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding renal function and corneal endothelial cell status, Ohguro et al [38] reported that polymegethism and pleomorphism were increased in patients with chronic renal failure. The amount of urea in the aqueous humor is known to increase in proportion to blood urea, and oxidized glutathione is increased in the aqueous humor in patients with renal failure, which is described as urea, and may be toxic to the corneal endothelium [39,40] . However, since our sample size was small, additional research and analyses are needed.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of corneal endothelial cell changes after phacoemulsification between type 2 diabetic and nondiabetic patients

Joo

Kim

2021

Medicine

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The aim of this study is to compare the endothelial cell density (ECD) and morphology between diabetic mellitus (DM) and nondiabetic patients at 1 year after phacoemulsification in operated eyes and nonoperated eyes. Evaluation was performed in 28 patients (56 eyes) with type 2 diabetes and 37 patients (74 eyes) without diabetes who underwent 1-year interval cataract surgery. Using a noncontact specular microscope and Scheimpflug rotating camera, corneal parameters were analyzed before and 1 year after surgery. Subgroups analysis was performed based on a disease duration 10 years and HbA1c concentration 7% and Pearson correlation analysis was performed. The mean change in ECD at 1 year after surgery was 13.28% in the DM group and 11.40% in the control group. In the fellow nonoperated eyes, the mean change was 4.47% and 3.63% in the DM and control groups, respectively. There was no significant difference in postoperative ECD, coefficient of variance, hexagonality, and central corneal thickness between 2 groups. In the subgroup analysis, the long disease duration DM group (≥10 years) had a significantly greater ECD loss than the control and short disease duration DM groups (<10 years). Blood urea nitrogen (BUN) showed a significant correlation with postoperative ECD change ( r = −0.474, P = .011). The diabetic group with a longer disease duration showed significantly greater ECD decrease compared to the nondiabetic group and BUN correlated with ECD changes after phacoemulsification. Postoperative ECD loss may be high if the disease duration is long or if the BUN level is high.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of corneal endothelial cell changes after phacoemulsification between type 2 diabetic and nondiabetic patients

Joo

Kim

2021

Medicine

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“…While no statistically signi cant differences were found in anemia or liver function tests between groups, renal function tests (BUN, creatinine) were found to be more common in group 1. The level of urea in the aqueous humor has been shown to increase with increased urea levels in the serum [29]. The design of this study is not suitable to understand the effects of increased blood urea and creatinine levels on DM/endothelium complex so further studies are needed to reveal the pathophysiology.…”

Section: Discussionmentioning

confidence: 96%

“…The level of urea in the aqueous humor has been shown to increase with increased urea levels in the serum. 30 The design of this study is not suitable to understand the effects of increased blood urea and creatinine levels on the DM-endothelium complex, so further studies are needed to reveal the pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

Effects of Systemic Diseases on Graft Preparation in Descemet Membrane Endothelial Keratoplasty

Özkan

Koçluk

Kasım

2022

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Purpose: To evaluate the effects of the systemic diseases and drugs of the donor on Descemet's membrane (DM) graft preparation.Methods: 78 corneas of 58 donors, of whom the DM grafts were used in Descemet's membrane endothelial keratoplasty (DMEK) surgery, between January 2018 -January 2020, were enrolled in this retrospective study. The hospital records of the donors were analyzed. Age, gender, blood type, systemic diseases, and drugs; complete blood count, biochemistry panel for liver and kidney functions in the last 48 hours, and the drugs used in the hospital, if any, in the last 24 hours were recorded. The grafts with tears that occurred while preparation, were included in group 1, and the successful grafts with no tears were included in group 2.Results: There were no statistically signi cant differences in the characteristics of the donors between groups. However, the breast cancer and the use of sevelamer were found to be signi cantly higher in group 1 (p=0.010, p=0.033, respectively) Conclusion: Although diabetic donors have been reported to be inappropriate candidates for the preparation of DM grafts for DMEK, most of the donors with several systemic diseases including diabetes can be used in DMEK surgery, with the right technique in DM graft preparation.

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Ophthalmic Pharmacology and Toxicology

Drance¹

1962

Archives of Ophthalmology

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Aqueous and Blood Urea Nitrogen Levels After Intravenous Urea Administration

Cited by 18 publications

References 7 publications

Comparison of corneal endothelial cell changes after phacoemulsification between type 2 diabetic and nondiabetic patients

Comparison of corneal endothelial cell changes after phacoemulsification between type 2 diabetic and nondiabetic patients

Effects of Systemic Diseases on Graft Preparation in Descemet Membrane Endothelial Keratoplasty

Ophthalmic Pharmacology and Toxicology

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