Aqueous Bark Extract of &lt;em&gt;Cinnamomum Zeylanicum&lt;/em&gt;: A Potential Therapeutic Agent for Streptozotocin- Induced Type 1 Diabetes Mellitus (T1DM) Rats

Hassan, Syed Atif; Barthwal, Ritu; Nair, Maya S.; Haque, Syed S

doi:10.4314/tjpr.v11i3.12

Cited by 26 publications

(26 citation statements)

References 16 publications

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“…Therefore, the product most probably can prevent dyslipidemia-related complications of diabetic patients. The hypolipidemic action of MSEC is in agreement with earlier studies that reported that A. sativum , C. zeylanicum, N. sativa , S. officinalis, and T. polium decrease the levels of serum triglyceride and cholesterol in diabetic animals [8, 11, 12, 16, 18]. …”

Section: Discussionsupporting

confidence: 91%

Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats

Shafiee-Nick

Ghorbani

Bagheri

et al. 2012

Advances in Pharmacological Sciences

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The effects of a polyherbal compound, containing six plants (Allium sativum, Cinnamomum zeylanicum, Nigella sativa, Punica granatum, Salvia officinalis and Teucrium polium) were tested on biochemical parameters in streptozotocin-induced diabetic rats. Streptozotocin caused an approximately 3-fold increase in fasting blood sugar level after 2 days. The diabetic control rats showed further increase in blood glucose after 30 days (384 ± 25 mg/dl in day 30 versus 280 ± 12 mg/dl in day 2, P < 0.001). Administration of the compound blocked the increase of blood glucose (272 ± 7 and 269 ± 48 mg/dl at day 2 and day 30, respectively). Also, there was significant difference in the level of triglyceride (60 ± 9 versus 158 ± 37 mg/dl, P < 0.01), total cholesterol (55 ± 2 versus 97 ± 11 mg/dl, P < 0.01) and aspartate amino transferase activity (75 ± 12 versus 129 ± 18 U/L, P < 0.05) between treated rats and diabetic control group. In conclusion, the MSEC inhibited the progression of hyperglycemia and decreased serum lipids and hepatic enzyme activity in diabetic rats. Therefore, it has the potential to be used as a natural product for the management of diabetes.

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Section: Discussionsupporting

confidence: 91%

Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats

Shafiee-Nick

Ghorbani

Bagheri

et al. 2012

Advances in Pharmacological Sciences

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“…Hassan et al have also shown similar results in diabetic subjects (39). In contrast to these observations, Sambaiah et al examined the effects of cinnamon on rats' lipid profiles at a concentration proportional to what is used in human diets, and indicated that this treatment did not change the animals' lipid profiles in a significant way (40).…”

Section: -mentioning

confidence: 78%

The Effects of Cinnamomum zeylanicum on Lipid Profiles and Histology Via Up-Regulation of LDL Receptor Gene Expression in Hamsters Fed a High Cholesterol Diet

Kassaee

Goodarzi

Roodbari

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: Recently, medicinal plants have become the focus of more attention due to their potentially effective roles in the prevention and treatment of many diseases. Objectives: The aim of this research was to examine the effects of Cinnamomum zeylanicum (CZ) on lipid profile and histological changes due to LDL receptor (LDL-R) gene expression in hamsters fed a high cholesterol diet. Methods: Thirty-two male hamsters were allocated into four groups (eight in each group under four weeks of treatment) as follows: group ND were fed a standard normal diet; group HCD were fed a normal diet supplemented with high cholesterol; group HCD + CZ2 were fed a high cholesterol diet (HCD) along with 2% CZ; and group HCD + CZ8 were fed an HCD diet along with 8% CZ. After the treatment process, blood samples were taken from all of studied animals, and sera were prepared for lipid profile assays. Liver LDL-R gene expression was assayed using the real-time polymerase chain reaction (PCR) method. Liver histological changes were determined using the hematoxylin and eosin staining method. Results: A significant reduction was observed in serum triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), very-low-density lipoprotein cholesterol (VLDL-c), aspartate transaminase (AST), and alanine transaminase (ALT) levels in the HCD + CZ8 group, while serum high density lipoprotein cholesterol (HDL-c) levels increased when compared with the HCD group (P < 0.001). The HCD group demonstrated decreased LDL-R gene expression in the animals' livers, whereas treatment with CZ upregulated its expression. The scores for hepatic steatosis in the HCD + CZ8 group were diminished significantly. Conclusions:The administration of CZ improved dyslipidemia in hypercholesterolemic animals, probably by increasing LDL-R gene expression in the liver; consequently, it can be concluded that CZ can reverse hepatic steatosis. Therefore, CZ was determined as having a protective role against hypercholesterolemia.

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“…[23] Cinnamonum zeylanicum (LAURACEAE): Aquous extract of cinnamonum zeylanicum significantly reduced total cholesterol, triglyceride, LDL-cholesterol and VLDL-cholesterol levels in streptozocin induced diabetic animal and elevated the tissue glycogen and HDL-cholesterol significantly [29]. Extract also showed improvement in glucose homeostatic enzymes indicating the antidiabetic activity of the extract.…”

Section: [22] Ougeinia Oojeinensis (Fabaceae)mentioning

confidence: 99%

Herbals and its marketed formulations to treat Diabetes Mellitus DM: An Overview

Gadhiya¹,

Jaithliya²,

Somani³

2018

IJTSRD

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Diabetes mellitus is one of the common metabolic disorder characterized by hyperglycemia due to defect in insulin secretion, insulin action or both and 2.8% of the population suffers from this disease throughout the world and it may cross 5.4% by the year 2025. This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. It also a very prevalent disease affecting the citizens of both developed and developing countries. There are lots of synthetic chemical agents available in market to control and treat diabetic patients like sulfonylurea, biguanides, etc. but total recovery from diabetes has not been reported up to this date. Alternative to these synthetic agents, many herbal plants with hypoglycaemic properties are known from across the world. Medicinal herbs as potential source of therapeutic aids have attained a significant role in health system all over the world for both humans and animals. India has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. Herbal medicines have shown good clinical practice in the therapy of diabetic mellitus. In This present paper aims to review various plant species and their constituents, which have been used in the traditional system of medicine and have shown hypoglycaemic activity and various branded herbal formulations like D-400 tablet, Diasulin powder, Madurisht churna, Diabecon, Dia-care, etc. available in the market as antidiabetic remedies are also discussed.

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Aqueous Bark Extract of <em>Cinnamomum Zeylanicum</em>: A Potential Therapeutic Agent for Streptozotocin- Induced Type 1 Diabetes Mellitus (T1DM) Rats

Cited by 26 publications

References 16 publications

Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats

Chronic Administration of a Combination of Six Herbs Inhibits the Progression of Hyperglycemia and Decreases Serum Lipids and Aspartate Amino Transferase Activity in Diabetic Rats

The Effects of Cinnamomum zeylanicum on Lipid Profiles and Histology Via Up-Regulation of LDL Receptor Gene Expression in Hamsters Fed a High Cholesterol Diet

Herbals and its marketed formulations to treat Diabetes Mellitus DM: An Overview

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