Aqueous decomposition behavior of solid peroxides: Effect of pH and buffer composition on oxygen and hydrogen peroxide formation

Rastinfard, Arghavan; Dalisson, Benjamin; Barralet, Jake E.

doi:10.1016/j.actbio.2022.04.004

Cited by 33 publications

(22 citation statements)

References 85 publications

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“…For the other prototypes, only a transient elevation in H 2 O 2 was observed, which may be compatible with most cell types, as the duration of exposure plays a key role in cytotoxicity particularly given the buffering capacity of culture media and physiological tissues. [49][50][51] It should be noted, however, that cells exhibit a range of sensitivities to ambient ROS and pH. Thus, care should be taken to contextualize these ranges to the targeted cells and/or tissues of interest.…”

Section: Discussionmentioning

confidence: 99%

Engineering Modular, Oxygen‐Generating Microbeads for the In Situ Mitigation of Cellular Hypoxia

Accolla

Liang

Lansberry

et al. 2023

Adv Healthcare Materials

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Insufficient oxygenation is a key obstacle in the design of clinically scalable tissue‐engineered grafts. In this work, an oxygen‐generating composite material, termed OxySite, is created through the encapsulation of calcium peroxide (CaO2) within polydimethylsiloxane and formulated into microbeads for ease in tissue integration. Key material parameters of reactant loading, porogen addition, microbead size, and an outer rate‐limiting layer are modulated to characterize oxygen generation kinetics and their suitability for cellular applications. In silico models are developed to predict the local impact of different OxySite microbead formulations on oxygen availability within an idealized cellular implant. Promising OxySite microbead variants are subsequently coencapsulated with murine β‐cells within macroencapsulation devices, resulting in improved cellular metabolic activity and function under hypoxic conditions when compared to controls. Additionally, the coinjection of optimized OxySite microbeads with murine pancreatic islets within a confined transplant site demonstrates ease of integration and improved primary cell function. These works highlight the broad translatability delivered by this new oxygen‐generating biomaterial format, whereby the modularity of the material provides customization of the oxygen source to the specific needs of the cellular implant.

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Section: Discussionmentioning

confidence: 99%

Engineering Modular, Oxygen‐Generating Microbeads for the In Situ Mitigation of Cellular Hypoxia

Accolla

Liang

Lansberry

et al. 2023

Adv Healthcare Materials

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“…The level of exhaled H 2 O 2 is extremely variable and depends on several factors that having a direct or indirect influence on its level. Environmental conditions, ventilatory pattern, measurement techniques and storage influence its concentration directly, but they may also act indirectly by changing the pH of EBC [ 40 , 210 , 211 , 212 , 213 , 214 , 215 ]. To limit variability due to sample storage and support point-of-care detection, different online detection systems and disposable sensors have been built and tested [ 212 , 216 , 217 , 218 , 219 , 220 , 221 ].…”

Section: Exhaled Hydrogen Peroxidementioning

confidence: 99%

Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics

et al. 2023

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Cancers, chronic diseases and respiratory infections are major causes of mortality and present diagnostic and therapeutic challenges for health care. There is an unmet medical need for non-invasive, easy-to-use biomarkers for the early diagnosis, phenotyping, predicting and monitoring of the therapeutic responses of these disorders. Exhaled breath sampling is an attractive choice that has gained attention in recent years. Exhaled nitric oxide measurement used as a predictive biomarker of the response to anti-eosinophil therapy in severe asthma has paved the way for other exhaled breath biomarkers. Advances in laser and nanosensor technologies and spectrometry together with widespread use of algorithms and artificial intelligence have facilitated research on volatile organic compounds and artificial olfaction systems to develop new exhaled biomarkers. We aim to provide an overview of the recent advances in and challenges of exhaled biomarker measurements with an emphasis on the applicability of their measurement as a non-invasive, point-of-care diagnostic and monitoring tool.

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“…The released H 2 O 2 under UV light generates $OH radicals which are powerful oxidizing agents that can oxidize contaminants. Inorganic solid oxidants like CaO 2 , MgO 2 and ZnO 2 are useful in different elds [15][16][17] including cancer treatment. There is only one study each on the peroxides of Mg & Zn for dye degradation.…”

Section: Introductionmentioning

confidence: 99%

Metal peroxides as potential photocatalysts for environmental remediation

et al. 2023

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Aqueous decomposition behavior of solid peroxides: Effect of pH and buffer composition on oxygen and hydrogen peroxide formation

Cited by 33 publications

References 85 publications

Engineering Modular, Oxygen‐Generating Microbeads for the In Situ Mitigation of Cellular Hypoxia

Engineering Modular, Oxygen‐Generating Microbeads for the In Situ Mitigation of Cellular Hypoxia

Exhaled Biomarkers for Point-of-Care Diagnosis: Recent Advances and New Challenges in Breathomics

Metal peroxides as potential photocatalysts for environmental remediation

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