Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues

Durak, Zahide Esra; Büber, Süleyman; Devrım, Erdinç; Kocaoğlu, Hakan; Durak, İlker

doi:10.4103/0973-1296.133232

Cited by 13 publications

(9 citation statements)

References 11 publications

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“…Aqueous extract from Taxus baccata inhibited adenosine deaminase (ADA) activities in both cancerous and noncancerous human gastric and colon tissues significantly. The ADA activities in human cancerous gastric and colon tissues were inhibited by 79.5 and 91.4%, respectively, in the study 14 . Aqueous and ethanolic extract of Taxus baccata leaf and Indian cow urine distillate showed synergistic anticancer effects as evidenced from good cytotoxicity and good recovery in clinico pathological parameters of Diethyl Nitrosamine induced hepatic cancer in mice 15 .…”

Section: Introductionmentioning

confidence: 83%

Anticancer Potential of Some Ayurvedic Plants of North Eastern India: A Comprehensive Pharmacological Review

Bora¹,

Baruah²,

Upadhyay³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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The paper highlights some of the most important Ayurvedic medicinal plants of North Eastern India having anticancer potential. A brief review of distribution and pharmacological study (both in vivo and in vitro) of ten Ayurvedic medicinal plants of the region published by various researchers is illustrated in this paper. The medicinal plants discussed here are Enhydra Fluctuans Lour (Sanskrit: Hilamochika), Ageratum conizoides Linn.

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Section: Introductionmentioning

confidence: 83%

Anticancer Potential of Some Ayurvedic Plants of North Eastern India: A Comprehensive Pharmacological Review

Bora¹,

Baruah²,

Upadhyay³

et al. 2017

Int. J. Res. Ayurveda Pharm.

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“…In our previous studies, we have found that extracts prepared from some plants like Taxus brefolia [48], Sillybum marianum [49] and Curcuma longa [50] could make significant inhibitions on the ADA activities in cancerous human gastric and colon tissues. In this study, we have also obtained similar results with Echinacea for gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Echinacea Inhibits Adenosine Deaminase Enzyme in Cancerous Human Gastric Tissue

Durak¹,

KocaoÃÂlu²

2015

J Carcinog Mutagene

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Aim: This study aims to investigate the possible effects of aqueous Echinacea (E. Purpurea, whole plant) extract on Adenosine deaminase (ADA) activity in cancerous and non-cancerous human gastric and colon tissues. Materials and Methods:Thirty three cancerous and 33 non-cancerous human gastric tissues, and 25 cancerous and non-cancerous human colon tissues removed by surgical operations were studied. In the samples, adenosine deaminase activities were measured with and without extract incubation.Results: It has been observed that Echinacea extract inhibits ADA enzyme in cancerous gastric tissues significantly. It exerts however no inhibitory effects on the ADA activities in the other tissues. Conclusion:It is proposed that inhibition of ADA enzyme by the Echinacea extract might play part in anti-cancer mechanism of Echinacea in some cancers like gastric cancer.

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“…Aqueous extract from T. baccata inhibits adenosine deaminase (ADA) activity significantly in cancerous and noncancerous human gastric and colon tissues (Durak et al, 2014). In addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA enzyme might also play a part in the anticancer properties of Taxus species.…”

Section: Anticancer Activitymentioning

confidence: 99%