Aqueous extract of Carica papaya Linn. roots potentially attenuates arsenic induced biochemical and genotoxic effects in Wistar rats

Abstract

In Africa, the fruit, leaf, seed and roots of Carica papaya Linn. are generally used to treat a variety of diseases such as malaria, cancer, and cardiovascular diseases. In this study, we evaluated the protective potentials of aqueous extract of C. papaya roots on arsenic-induced biochemical and genotoxic effects in Wistar rats. Rats were induced intraperitoneal with sodium arsenate (dissolved in distilled water at 3 mg/kg body weight) for 21 days and the animals were administered simultaneously with 200 mg/kg body weight vitamin C, 100 and 150 mg/kg body weight of the C. papaya Linn. root aqueous extract once daily for three weeks. Results obtained reveals that activities of plasma 8-OHdG, serum lipids concentration, atherogenic index (AI), coronary artery index (CRI), aspartate transaminase, alanine transaminase, alkaline phosphatase, total bilirubin levels were elevated significantly (p < 0.05) and catalase, glutathione peroxidase, superoxide dismutase, plasma hematological profile were progressively reduced (p < 0.05) in arsenic-alone exposed rats. Significant increase in the quantity of chromosomal aberrations (CA), micronuclei (MN) frequency, oxidative damages in the bone marrow cells from arsenic alone rats was observed. Though, mitotic index scores in these cells were progressively reduced (p < 0.05). In animals administered with aqueous extract of C. papaya roots and vitamin C, the altered parameters were significantly recovered towards the levels observed in normal control rats. These results suggest that aqueous C. papaya roots preparations might have therapeutic potential as a supplement that can be applied in arsenic poisoning.

Comparative Evaluation of the In Vitro Anthelminthic Effects of the Leaves, Stem, and Seeds of Carica papaya (Linn) Using the Pheretima posthuma Model

“…e leaves are thought to increase breast milk and used in the treatment of tonsillitis, ulcerative stomatitis, and gingivitis [12]. e roots have been suggested to be beneficial in managing arsenic poisoning [13]. Different preparations from the leaves have found use in managing haemorrhoids, management of asthma, treatment of urinary tract infections, poultice for sores [12], and treatment of helminth infections [14].…”

Effect of an Edible Coating Based on Chitosan and Oxidized Starch on Shelf Life of Carica papaya L., and Its Physicochemical and Antimicrobial Properties

“…Papaya (Carica papaya L.) is a perennial plant with a rapid growth, and it provides fruits for more than twenty years [1]. Papaya is considered one of the most important fruits worldwide because of its high contents of ascorbic acid, provitamin A, calcium, and carotenoids [2].…”

Carica papaya and Mangifera indica modulate haematological, biochemical and histological alterations in atrazine-intoxicated fish, Clarias gariepinus (Burchell 1822)

“…Although the ameliorative effects of both the CPE and MIE on atrazine-induced toxicity in fish have not been reported so far, previous studies have suggested the in vivo ameliorative potentials of the two extracts against toxins in mammalian models (Adeneye et al, 2015;Awodele et al, 2016;Ojo et al, 2018). The results of these studies are in tandem with those observed in the present study regarding the prevention of leakage of tissue enzyme biomarkers from the cytoplasm, where they are originally domiciled, into adjacent cells and general circulation, and the antioxidant property of the extracts.…”