Aqueous extract of Polygonatum sibiricum ameliorates glucose and lipid metabolism via PI3K / AKT signaling pathway in high‐fat diet and streptozotocin‐induced diabetic mice

Abstract

This study was aimed to investigate the protective effects and elucidate the mechanisms of aqueous extract of Polygonatum sibiricum (PSAE) on glucolipid metabolism during the development of type 2 diabetes (T2DM). C57BL/6J mice fed with 60% high‐fat diet (HFD) combined with streptozotocin (STZ) injection to simulate the occurrence process of T2DM. PSAE was administered daily by oral gavage during the experiment. The results demonstrated the protective effects in mice supplied with PSAE on the indicators of glycolipid metabolism (body weight, fasting blood glucose, the area under the curve, hemoglobin A1c, serum total cholesterol, triglyceride, low‐density lipoprotein cholesterol, and liver triglyceride) compared with the Model group mice. Furthermore, PSAE can ameliorate insulin resistance in mice liver by activating phosphoinositide‐3‐kinase/protein kinase B (PI3K/AKT) pathway signaling. Overall, our research suggested that PSAE can effectively regulate glucose and lipid metabolism during the development of T2DM as an alternative functional food. Practical applications Diabetes is a chronic metabolic disease which is characterized by abnormal metabolism of glucose and lipoid and nowadays it has been one of the most representative chronic systemic progressive metabolic diseases. Polygonatum sibiricum is a traditional Chinese galenical and it also can be used as food ingredients. PSAE is the aqueous extract of Polygonatum sibiricum. 34% polysaccharides were detected in PSAE and it can effectively regulate glucose and lipid metabolism during the development of T2DM in mice. Thus, PSAE might be a promising functional food for regulation of glucolipid metabolism and the study also provides a theoretical basis for the development and application of food about Polygonatum sibiricum.

Regulation of Glucolipid Metabolism in Mice Using Dendrobium huoshanense Extract and PI3k/Akt Signaling Pathway Activation

“…Many studies have shown that interfering with PI3K/Akt and other pathways can result in hypoglycemic efects [39,40]. By activating the PI3K/AKT signaling pathway, the aqueous extract of Flos Aureus is also able to improve hepatic insulin resistance in mice [41]. Extracts from a variety of plants, such as white buttercup and Acanthopanax, have also been shown to afect glycolipid metabolism in mice by this pathway [18,42,43].…”

Traditional herbs: mechanisms to combat cellular senescence

“…In studies based on hyperlipidemic and obese mouse models, Thujaplicins reduced the expression levels of SREBPs and PPARα and exerted regulatory lipid metabolism and antiinflammatory effects through activation of the AMPK signaling pathway [122,123]. In studies based on T2DM mice, Thujaplicins and aqueous extracts of C. tigris reduced blood glucose levels and blood lipid levels in mice, and Thujaplicins also repaired pancreatic β-cells to improve disorders of glucolipid metabolism [124,125].…”

Black Rice Anthocyanidins Regulates Gut Microbiota and Alleviates Related Symptoms through PI3K/AKT Pathway in Type 2 Diabetic Rats

“…Currently, clinical drugs for the treatment of diabetes may have certain side efects and their application is limited. More evidence shows that dietary modifcations can alleviate dyslipidemia and hyperglycemia to some extent [9,13], so the risk of developing T2DM and its complications can be reduced by consuming plants and their bioactive ingredients with efcacy and safety.…”