Aqueous extract of Stevia rebaudiana (Bertoni) Bertoni abrogates death‐related signaling pathways via boosting the expression profile of oxidative defense systems

Abstract

Diabetes is recognized as a disease with large social, financial, and health system burdens across the world. It is recently reported that 451 million people were living with diabetes in 2017, worldwide, which is expected to increase to 693 million by 2045 (Cho et al., 2018).The discovery of insulin in 1922, strongly helped the control of diabetes mellitus type 1 (DM1), but oral administration of insulin is impossible and daily injection could cause side effects such as hypoglycemic-allergic reaction in patients with diabetes. Also, insulin resistance is another major drawback for patients with DM1