Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

Li, Jingjie; Zheng, Lianwen; Gu, Lijuan; Wang, Yunbo; Lee, Mi-ra; Sung, Chang‐Keun

doi:10.1155/2014/878162

Cited by 6 publications

(6 citation statements)

References 32 publications

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“…27 28 It is believed that a variety of important growth factors that drive rapid regeneration of velvet antler may be associated with its growth-promoting activity. 13 In Traditional Chinese Medicine, velvet antler can be regarded as an effective promoter of health, which promotes rapid growth and regeneration by tonic action. 22 However, the detailed underlying mechanism remained less understood.…”

Section: Research Articlementioning

confidence: 99%

Antler Collagen/Chitosan Scaffolds Improve Critical Calvarial Defect Healing in Rats

Yu¹,

Huang²,

Wang³

et al. 2015

j biomater tissue eng

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This study was to develop chitosan scaffolds combined with collagen derived from deer antler and test its in vivo bone regeneration capacity in the calvarial defect model. Chitosan was crosslinked with deer antler-derived collagen by chemical reaction and lyophilized to attain porous scaffolds. Untreated chitosan was taken as control. Proliferation rate of rat bone marrow-derived mesenchymal stem cells was measured at 3 or 5 day after seeded on the porous scaffold in vitro. Sprague-Dawley rats were subjected to operation to make calvarial bone critical defects. Then the defects were left empty or implanted with chitosan scaffolds, or antler collagen/chitosan (A-collagen/chitosan) scaffolds. Samples were collected for micro-CT then decalcified for histology analysis 8 weeks post-surgery. Cell proliferation was significantly enhanced when they seeded onto the A-collagen/chitosan scaffolds compared with chitosan only scaffolds. The volume of mineralized tissue was also markedly increased in the calvarial defect region when implanted with A-collagen/chitosan compared with chitosan only scaffolds. Histological results also showed more new bone forming beneath the A-collagen/chitosan scaffolds, which was consistent with that of micro-CT analysis. In conclusion, A-collagen/chitosan scaffolds showed promising reparative effect in rat critical-sized calvarial bone defect models.

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Section: Research Articlementioning

confidence: 99%

Antler Collagen/Chitosan Scaffolds Improve Critical Calvarial Defect Healing in Rats

Yu¹,

Huang²,

Wang³

et al. 2015

j biomater tissue eng

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“…Pilose antler contains biologically active components including proteins, peptides, amino acids, and a variety of growth factors (such as insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and nerve growth factor (HGF), which have physiological activities such as promoting wound healing, enhancing immunity, and promoting cell regeneration ( Sui et al, 2014 ). Furthermore, in recent studies, some certain bioactive protein extracts from pilose antler were proven to be delivered through the skin, efficiently fostering hair growth ( Li et al, 2014 ; Tansathien et al, 2021 ), and it has been shown that uridine, a metabolite in pilose antler, has a significant role in hair growth ( Liu et al, 2022 ). However, until now, it’s unclear whether pilose antler could alleviate the AGA disease.…”

Section: Introductionmentioning

confidence: 99%

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Wang,

He,

Liu

et al. 2024

Front. Pharmacol.

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Background: Angrogenetic alopecia (AGA) is one of the most prevalent hair loss disorders worldwide. The hair follicle stem cell (HFSC) is closely related to the formation of hair follicle (HF) structure and HF self-renewal. The activation of HFSC in AGA is critical for hair growth. Pilose antler has been reported to have hair growth-promoting activity, but the mechanism of action on AGA and HFSC has not been reported.Methods: We previously extracted an active component from the pilose antler known as PAEs. In this study, we conducted experiments using AGA mice and HFSC. The effects of PAEs on hair growth in AGA mice were firstly detected, and then the mechanisms of PAEs for AGA were predicted by integrating network pharmacology and de novo transcriptomics data of pilose antler. Finally, biological experiments were used to validate the molecular mechanism of PAEs in treating AGA both in vivo and in vitro.Results: It was found that PAEs promoted hair regrowth by accelerating the activation of anagen, delaying the anagen-catagen transition. It also alleviated the morphological changes, such as hair shortening, thinning, miniaturization, and HF number reduction, and regulated the hair regeneration process of four subtypes of hair. We further found that PAEs could promote the proliferation of HFSC, outer root sheath (ORS) cells, and hair bulb cells in AGA mice. We then integrated network pharmacology and pilose antler transcriptomics data to predict that the mechanism of PAEs treatment in AGA mice is closely related to the PI3K-AKT/Wnt-β-Catenin pathways. Subsequently, it was also verified that PAEs could activate both pathways in the skin of AGA mice. In addition, we found that PAEs perhaps increased the number of blood vessels around dermal papilla (DP) in experiments in vivo. Meanwhile, the PAEs stimulated the HFSC proliferation in vitro and activated the AKT and Wnt pathways. However, the proliferative activity of HFSC was inhibited after blocking the Wnt pathway and AKT activity.Conclusion: This study suggests that the hair growth-promoting effect of PAEs in AGA mice may be closely related to the stimulation of the AKT and Wnt pathways, which in turn activates the proliferation of HFSC.

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“…The effect of deer antler extract was believed to strengthen the body, improve immune function, and regulate cardiovascular health and function. In particular, recent studies have reported that the biological effects of deer antler extracts include promotion of hair growth and hematopoietic properties [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

13-Week repeated oral dose toxicity study on mixture of Korean red ginseng and deer antler extract in Sprague-Dawley rats

et al. 2019

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Owing to an increase in the consumption of herbal products as supplementary diets or functional foods, their safety has become an important issue. Repeated oral administration to rats for 13-week was performed to evaluate the potential toxicity of a mixture of Korean red ginseng and deer antler extract, the most popular traditional herbal ingredients. Three test groups for the mixture of Korean red ginseng and deer antler extract were administered at 500, 1000, and 2000 mg/kg/day in addition to a control group (water for injection). 10 male and 10 female rats were included in each group, and we evaluated the clinical, clinicopathological, and histopathological changes in the rats. One male rat in the test group at 1000 mg/ kg/day died; however, it was considered a spontaneous death unrelated to the administration of the test substance. No test substance-related toxic effects were noted in rats in terms of body weight, food consumption, ophthalmological findings, urinalysis, hematological parameters, blood biochemical parameters, organ weights, gross postmortem findings, and histopathological findings. The present results suggest that the no observed adverse effect level of the mixture of Korean red ginseng and deer antler extract was greater than 2000 mg/kg/day in all rats after repeated oral administration for 13-week under the present study conditions. KeywordsKorean red ginseng extract • Deer antler extract • 13-Weeks repeated oral dose toxicity study • No-observedadverse-effect level * Seung-Ho So

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Aqueous Extract of Red Deer Antler Promotes Hair Growth by Regulating the Hair Cycle and Cell Proliferation in Hair Follicles

Cited by 6 publications

References 32 publications

Antler Collagen/Chitosan Scaffolds Improve Critical Calvarial Defect Healing in Rats

Antler Collagen/Chitosan Scaffolds Improve Critical Calvarial Defect Healing in Rats

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

13-Week repeated oral dose toxicity study on mixture of Korean red ginseng and deer antler extract in Sprague-Dawley rats

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