Aqueous extracts and suspensions of restructured pork formulated with Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis distinctly affect the in vitro α-glucosidase activity and glucose diffusion

Garcimartín, Alba; Benedı́, Juana; Bastida, Sara; Sánchez‐Muniz, Francisco J.

doi:10.1016/j.lwt.2015.06.050

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…It is necessary to look for effective therapeutic natural medications with less side effects. Garcimartn et al [263] showed that a α-glucosidase inhibitory effect on restructured pork treated with seaweeds such as Undaria pinnatifida, Himanthalia elongata, and Porphyra umbilicalis caused a reduction in the blood glucose absorption. Padina tetrastromatica phenolic extracts inhibited both α -glucosidase and α -amylase, with higher inhibition linked with a higher phenolic concentration in the extracts.…”

Section: Antidiabetics Activitymentioning

confidence: 99%

Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review

et al. 2022

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Since ancient times, seaweeds have been employed as source of highly bioactive secondary metabolites that could act as key medicinal components. Furthermore, research into the biological activity of certain seaweed compounds has progressed significantly, with an emphasis on their composition and application for human and animal nutrition. Seaweeds have many uses: they are consumed as fodder, and have been used in medicines, cosmetics, energy, fertilizers, and industrial agar and alginate biosynthesis. The beneficial effects of seaweed are mostly due to the presence of minerals, vitamins, phenols, polysaccharides, and sterols, as well as several other bioactive compounds. These compounds seem to have antioxidant, anti-inflammatory, anti-cancer, antimicrobial, and anti-diabetic activities. Recent advances and limitations for seaweed bioactive as a nutraceutical in terms of bioavailability are explored in order to better comprehend their therapeutic development. To further understand the mechanism of action of seaweed chemicals, more research is needed as is an investigation into their potential usage in pharmaceutical companies and other applications, with the ultimate objective of developing sustainable and healthier products. The objective of this review is to collect information about the role of seaweeds on nutritional, pharmacological, industrial, and biochemical applications, as well as their impact on human health.

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Section: Antidiabetics Activitymentioning

confidence: 99%

Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review

et al. 2022

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“…There have been indications that algae could be used as antidiabetic foods/ingredients, but the mechanisms of action remain unclear. Likewise, it is important to differentiate between including a whole alga or an extract, because the extraction process determines the subsequent activity observed, or their isolated compounds [ 22 , 23 ]. Despite their potential health benefits, recent controversy exists about the utility of algae as some adverse events have been associated with their consumption.…”

Section: Introductionmentioning

confidence: 99%

Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus

Burgos

Macho-González

Garcimartín

et al. 2021

IJMS

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Type-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioactive molecules with potential antidiabetic activity. This review delves into the applications of algae and their components in T2DM, as well as to ascertain the mechanism involved (e.g., glucose absorption, lipids metabolism, antioxidant properties, etc.). PubMed, and Google Scholar databases were used. Papers in which whole alga, algal extracts, or their isolated compounds were studied in in vitro conditions, T2DM experimental models, and humans were selected and discussed. This review also focuses on meat matrices or protein concentrate-based products in which different types of alga were included, aimed to modulate carbohydrate digestion and absorption, blood glucose, gastrointestinal neurohormones secretion, glycosylation products, and insulin resistance. As microbiota dysbiosis in T2DM and metabolic alterations in different organs are related, the review also delves on the effects of several bioactive algal compounds on the colon/microbiota-liver-pancreas-brain axis. As the responses to therapeutic diets vary dramatically among individuals due to genetic components, it seems a priority to identify major gene polymorphisms affecting potential positive effects of algal compounds on T2DM treatment.

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“…It is critical to seek effective therapeutic natural drugs that have fewer negative effects. In this case, one seaweed compound (phenolic compound or fucoidan) [59,146] or two conjugated compounds from seaweeds (crude ethanolic extract) [147] can be a key to seaweeds being a natural therapeutic for diabetes. Nonetheless, dieckol increased the activity of antioxidant enzymes in liver tissues, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-px), as well as the phosphorylation of AMPK and Akt in muscle tissues, implying that dieckol could be developed as a therapeutic agent for type 2 diabetes [123,128].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Seaweeds as Nutraceutical Elements and Drugs for Diabetes Mellitus: Future Perspectives

Cotas,

Lomartire,

Pereira

et al. 2024

Marine Drugs

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Diabetes mellitus is a chronic metabolic condition marked by high blood glucose levels caused by inadequate insulin synthesis or poor insulin use. This condition affects millions of individuals worldwide and is linked to a variety of consequences, including cardiovascular disease, neuropathy, nephropathy, and retinopathy. Diabetes therapy now focuses on controlling blood glucose levels through lifestyle changes, oral medicines, and insulin injections. However, these therapies have limits and may not successfully prevent or treat diabetic problems. Several marine-derived chemicals have previously demonstrated promising findings as possible antidiabetic medicines in preclinical investigations. Peptides, polyphenols, and polysaccharides extracted from seaweeds, sponges, and other marine species are among them. As a result, marine natural products have the potential to be a rich source of innovative multitargeted medications for diabetes prevention and treatment, as well as associated complications. Future research should focus on the chemical variety of marine creatures as well as the mechanisms of action of marine-derived chemicals in order to find new antidiabetic medicines and maximize their therapeutic potential. Based on preclinical investigations, this review focuses on the next step for seaweed applications as potential multitargeted medicines for diabetes, highlighting the bioactivities of seaweeds in the prevention and treatment of this illness.

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Aqueous extracts and suspensions of restructured pork formulated with Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis distinctly affect the in vitro α-glucosidase activity and glucose diffusion

Cited by 11 publications

References 26 publications

Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review

Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review

Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus

Seaweeds as Nutraceutical Elements and Drugs for Diabetes Mellitus: Future Perspectives

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