Aqueous flare is increased in patients with clinically significant cystoid macular oedema after cataract surgery

Ersoy, Lebriz; Caramoy, Albert; Ristau, Tina; Kirchhof, Bernd; Fauser, Sascha

doi:10.1136/bjophthalmol-2012-302995

Cited by 48 publications

(54 citation statements)

References 14 publications

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“…Therefore it seems reasonable to take strong measures to minimize the inflammatory process, possibly including the administration of both corticosteroids and NSAIDs together. A recent study by Ersoy et al [65] that quantitatively assessed aqueous flare after phacoemulsification reported that patients who developed CME had significantly higher flare values than those who did not, suggesting that inflammatory pathogenesis and a breakdown of the blood-ocular barrier may be involved.…”

Section: Macular Edema After Cataract Surgerymentioning

confidence: 99%

Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema

Russo

Costagliola

Delcassi

et al. 2013

Mediators of Inflammation

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are nowadays widely used in ophthalmology to reduce eye inflammation, pain, and cystoid macular edema associated with cataract surgery. Recently, new topical NSAIDs have been approved for topical ophthalmic use, allowing for greater drug penetration into the vitreous. Hence, new therapeutic effects can be achieved, such as reduction of exudation secondary to age-related macular degeneration or diabetic maculopathy. We provide an updated review on the clinical use of NSAIDs for retinal diseases, with a focus on the potential future applications.

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Section: Macular Edema After Cataract Surgerymentioning

confidence: 99%

Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema

Russo

Costagliola

Delcassi

et al. 2013

Mediators of Inflammation

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“…Excess sterile intraocular postoperative inflammation and breakdown of the bloodretinal barrier as marked by aqueous flare have been shown to be connected with the risk for PCME (Ersoy et al 2013). Excess sterile intraocular postoperative inflammation and breakdown of the bloodretinal barrier as marked by aqueous flare have been shown to be connected with the risk for PCME (Ersoy et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Anti‐inflammatory medication following cataract surgery: a randomized trial between preservative‐free dexamethasone, diclofenac and their combination

Ylinen

Holmström

Laine

et al. 2018

Acta Ophthalmologica

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“…With the advancement of surgical technique and the improvement of surgical outcome, one of the main concerns for surgeons is to avoid or treat CME in pseudophakic patients 5 . Atraumatic surgery itself may be considered a prophylactic measure for edema 26 . Currently no standardized protocol exists for the prophylaxis and management of PCME because of a lack of prospective randomized clinical trials.…”

Section: Prophylaxis For Cmementioning

confidence: 99%

Cistoidni makularni edem nakon operacije katarakte

Merlak

Gržetić-Lenac

Babić

et al. 2019

Med. Flum. (Online)

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Pseudophakic cystoid macular edema (PCME) is the most common complication of cataract surgery and is one of the possible causes of low visual acuity after cataract surgery. Various factors are implicated in its development but the core mechanism is likely surgically induced anterior segment inflammation that results in the release of endogenous inflammatory mediators. Anti-inflammatory medicines, including steroid and nonsteroid anti-inflammatory drugs, are postulated as having a role in both the prophylaxis and treatment of PCME. This article presents an updated review on the pathogenesis, risk factors, prophylaxis and treatment in PCME that reflect current research and practice.Sažetak: Cistoidni makularni edem komplikacija je nakon operacije katarakte i najčešći je uzrok loše vidne oštrine nakon operacije katarakte. Različiti su patofiziološki mehanizmi nastanka makularnog edema, ali najčešće se dovodi u vezu s postoperativnom upalom pri kojoj se oslobađaju medijatori upale i dovode do nakupljanja tekućine u području makule. Protuupalni lijekovi, uključujući steroide i nesteroidne antireumatike, imaju veliku ulogu u profilaksi i terapiji cistoidnog makularnog edema. U ovom preglednom članku prikazani su najnoviji stavovi o patogenetskom mehanizmu nastanka edema, rizičnim faktorima, profilaksi i terapiji, proizišli iz istraživanja i kliničke prakse.

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Aqueous flare is increased in patients with clinically significant cystoid macular oedema after cataract surgery

Abstract: Aqueous flare as a marker for inflammation and breakdown of the blood-retinal barrier is increased in patients with CME after cataract surgery.

Cited by 48 publications

References 14 publications

Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema

Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema

Anti‐inflammatory medication following cataract surgery: a randomized trial between preservative‐free dexamethasone, diclofenac and their combination

Cistoidni makularni edem nakon operacije katarakte

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