Aqueous Humor Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Bevacizumab in Type 3 Versus Type 1 and 2 Neovascularization. A Prospective, Case-Control Study

dell’Omo, Roberto; Cassetta, Marilluccia; dell’Omo, Ermanno; Salvatore, Angela Di; Hughes, John M.; Aceto, Fabiana; Porcellini, Antonio; Costagliola, Ciro

doi:10.1016/j.ajo.2011.06.001

Cited by 40 publications

(26 citation statements)

References 42 publications

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“…VEGF and PEDF levels in the aqueous humour of patients with PM are quite different than the levels recorded in patients with diabetes or with AMD 10. Despite differences in AMD, diabetes and PM pathogenesis, there is evidence that VEGF may play a role in the development of CNV in PM, as well as in other neovascular eye diseases 20.…”

Section: Discussionmentioning

confidence: 86%

“…Lastly, in a 4-year follow-up of highly myopic patients with CNV treated with anti-VEGF drugs, Ruiz-Moreno et al 8 reported that intravitreal bevacizumab and ranibizumab are effective therapies and show similar clinical effects. However, VEGF concentrations in the aqueous humour of patients with myopic CNV (mCNV) are lower than that in normal controls9 and in patients with age-related macular degeneration (AMD) 10…”

Section: Introductionmentioning

confidence: 99%

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Effect of intravitreal ranibizumab injections on aqueous humour concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in patients with myopic choroidal neovascularisation

et al. 2015

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effect of intravitreal ranibizumab injections on aqueous humour concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in patients with myopic choroidal neovascularisation

et al. 2015

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“…It is clear that VEGF is the major stimulus for vascular endothelial cell proliferation during progression of AMD, and many studies have shown elevation of intraocular VEGF levels in patients with AMD [10,11]. However, macular edema sometimes persists and progresses despite intravitreal anti-VEGF therapy.…”

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confidence: 99%

Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

et al. 2018

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Purpose: To compare aqueous humor levels of various cytokines between patients with age-related macular degeneration (AMD) and cataract patients. Methods: Thirteen eyes with wet-type AMD (AMD group) and 14 eyes with cataract (cataract group) were studied. Aqueous humor levels of 11 factors (vascular endothelial growth factor receptors, growth factors, and inflammatory factors) were measured by the suspension array method. Results: Aqueous humor levels of vascular endothelial growth factor, soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and inflammatory factors (monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, and IL-8) were significantly higher in the AMD group than in the cataract group (all p < 0.05). In contrast, aqueous humor levels of placental growth factor (PGF), tumor necrosis factor-α, soluble intercellular adhesion molecule (sICAM)-1, IL-12 (p70), and IL-13 showed no significant difference between the two groups. There were significant correlations between sVEGFR-1 or sVEGFR-2 levels and some of the inflammatory molecules (PGF, sICAM-1, MCP-1, IL-6, and IL-8). Conclusions: These findings suggest that various cytokines/growth factors involved in inflammation and angiogenesis may be associated with the pathogenesis of AMD.

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“…Neovascularization was subdivided into three categories according to previous descriptions. 6,25 Briefly, in type 1 NV, new vessels are located beneath the RPE. The type 1 NV patient group included 13 patients with polypoidal choroidal vasculopathy (PCV), which was diagnosed based on the presence of prominent ''polyps'' and a branching of the choroidal vascular network that was visualized by ICGA.…”

Section: Patient Datamentioning

confidence: 99%

“…Proteins or cytokines in the aqueous humor (AH), such as VEGF, have been used as biomarkers of neovascular AMD (nAMD), neovascularization, and disease activity associated with AMD. 5,6 However, no proteins or cytokines that reflect the status or function of the retina and photoreceptors in this disease have been previously described in the AH of AMD patients.…”

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confidence: 99%

Wnt Modulators in the Aqueous Humor Are Associated With Outer Retinal Damage Severity in Patients With Neovascular Age-Related Macular Degeneration

Park

Choi

Yoon

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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Citation: Park KH, Choi AJ, Yoon J, et al. Wnt modulators in the aqueous humor are associated with outer retinal damage severity in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014;55:5522-5530. DOI: 10.1167/iovs.14-14566 PURPOSE. To investigate the associations of the Wnt modulators Wnt inhibitory factor 1 (WIF-1) and Dickkopf 3 (DKK-3) in the aqueous humor with neovascular age-related macular degeneration (nAMD) and to determine their clinical implications.METHODS. Seventy-four nAMD patients initially treated with an intravitreal injection of ranibizumab (IVR) and 74 age-and sex-matched controls were studied. Aqueous humor WIF-1 and DKK-3 levels were measured by Western blotting and an ELISA before and 1 month after two consecutive IVRs (pre-and post-IVR). Visual acuity assessments and spectral domain optical coherence tomography were performed pre-and post-IVR. RESULTS.Western blotting showed increased WIF-1 and DKK-3 in 12 nAMD patients compared with 12 controls. The ELISA analysis demonstrated elevated WIF-1 (pre) and DKK-3 (pre) in 62 patients compared with 62 controls (54.7 vs. 23.0 and 114.3 vs. 93.0 ng/mL, respectively). In multivariate analyses, high WIF-1 (pre) levels were associated with increased disruption in the photoreceptor junction's inner and outer segments (IS/OS) (pre and post) and high WIF-1 (post) levels. Interestingly, WIF-1 (pre) levels were significantly higher in type 3 neovascularization (NV) patients than in type 1 or 2 NV (90.5 6 36.7 vs. 48.3 6 22.5 and 41.3 6 28.8 ng/mL, respectively). However, choroidal thickness was not correlated with WIF-1 levels.CONCLUSIONS. We report, for the first time, the possibility of phenotypic, anatomic, and ocular proteomic correlations, demonstrating correlated WIF-1 and DKK-3 upregulation in nAMD patients' aqueous humor. Secreted WIF-1, reflecting the degree of retinal structure damage, may be a new biomarker for the retina's healthy and disease states.

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Aqueous Humor Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Bevacizumab in Type 3 Versus Type 1 and 2 Neovascularization. A Prospective, Case-Control Study

Cited by 40 publications

References 42 publications

Effect of intravitreal ranibizumab injections on aqueous humour concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in patients with myopic choroidal neovascularisation

Effect of intravitreal ranibizumab injections on aqueous humour concentrations of vascular endothelial growth factor and pigment epithelium-derived factor in patients with myopic choroidal neovascularisation

Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

Wnt Modulators in the Aqueous Humor Are Associated With Outer Retinal Damage Severity in Patients With Neovascular Age-Related Macular Degeneration

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