Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients

Özeç, Ayşe Vural; Dursun, Ayhan; Toker, Mustafa; Demirci, Yüksel; Topalkara, Ayşen; Erdoğan, Haydar; Arıcı, Mustafa Kemal; Ersalcan, Taner

doi:10.1007/s10384-014-0322-8

Jpn J Ophthalmol

2014

DOI: 10.1007/s10384-014-0322-8

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Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients

Ayşe Vural Özeç

Ayhan Dursun

Mustafa Toker

et al.

Abstract: This study is the first to report elevated levels of ghrelin in the AqH in eyes exhibiting exfoliation syndrome. Findings suggest ghrelin might play role in the etiopathogenesis of exfoliation syndrome to exfoliation glaucoma.

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“…In the aqueous humor of patients with glaucoma, ghrelin levels are significantly lower than that of control patients. [19][20][21] Ghrelin treatment significantly decreases the intraocular pressure in rat and rabbit acute ocular hypertension models, 18 and TUNEL positivity of retinal cells in a rat experimental glaucoma model, by reversing the increased levels of malondialdehyde and nitric oxide synthase-2 in anterior chamber fluid and tissues. 22 These results suggest that the ghrelin-GHSR-1a system may provide a neuroprotective effect in glaucoma.…”

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confidence: 99%

Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model

Zhu

Zhang

Liu

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Ghrelin, a natural ligand for the growth hormone secretagogue receptor type 1a (GHSR-1a), may protect retinal neurons against glaucomatous injury. We therefore characterized the underlying mechanism of the ghrelin/GHSR-1a-mediated neuroprotection with a rat chronic intraocular hypertension (COH) model. METHODS.The rat COH model was produced by blocking episcleral veins. A combination of immunohistochemistry, Western blot, TUNEL assay, and retrograde labeling of retinal ganglion cells (RGCs) was used.RESULTS. Elevation of intraocular pressure induced a significant increase in ghrelin and GHSR1a expression in retinal cells, including RGCs and Müller cells. Western blot confirmed that the protein levels of ghrelin exhibited a transient upregulation at week 2 after surgery (G2w), while the GHSR-1a protein levels were maintained at high levels from G2w to G4w. In COH retinas, the ratio of LC3-II/LC-I and beclin1, two autophagy-related proteins, were increased from G1w to G4w, and the cleavage product of caspase3, an apoptotic executioner, was detected from G2w to G4w. Intraperitoneal injection of ghrelin significantly increased the number of surviving RGCs; inhibited the changes of LC3-II/LC-I, beclin1, and the cleavage products of caspase3; and reduced the number of TUNEL-positive cells in COH retinas. Ghrelin treatment also reversed the decreased levels of p-Akt and p-mTOR, upregulated GHSR-1a protein levels, and attenuated glial fibrillary acidic protein levels in COH retinas.CONCLUSIONS. All these results suggest that ghrelin may provide neuroprotective effect in COH retinas through activating ghrelin/GHSR-1a system, which was mediated by inhibiting retinal autophagy, ganglion cell apoptosis, and Müller cell gliosis.

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confidence: 99%

Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model

Zhu

Zhang

Liu

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Comparison of total/active ghrelin levels in primary open angle glaucoma, pseudoexfoliation glaucoma and pseudoexfoliation syndrome

et al. 2018

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Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients

Abstract: This study is the first to report elevated levels of ghrelin in the AqH in eyes exhibiting exfoliation syndrome. Findings suggest ghrelin might play role in the etiopathogenesis of exfoliation syndrome to exfoliation glaucoma.

Cited by 2 publications

References 21 publications

Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model

Ghrelin Attenuates Retinal Neuronal Autophagy and Apoptosis in an Experimental Rat Glaucoma Model

Comparison of total/active ghrelin levels in primary open angle glaucoma, pseudoexfoliation glaucoma and pseudoexfoliation syndrome

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