Aqueous Methanolic Bark Extract of Oroxylum indicum Inhibited Testosterone induced Prostate Hyperplasia in Rat

Abstract

Oroxylum indicum is a frequently reported traditional medicinal plant known to possess antiproliferative and antitumor activity. The present study investigated the effect of crude methanolic bark extract of Oroxylum indicum on testosterone induced benign prostate hyperplasia (BPH) in rat. Adult male rats were given either corn oil or testosterone dissolved in corn oil and testosterone with aqueous methanolic bark extracts of Oroxylum indicum (10, 50 and 100 mg/kg/day) for 14 days. The inhibitory effect of Oroxylum indicum on testosterone induced hyperplasia was evaluated by prostatic index and histopathological examination. Serum marker of liver injury (alanine aminotransferase, ALT and aspartate aminotransferase, AST) and liver histopathological examination were also conducted. Compared with testosterone induced BPH model group, Oroxylum indicum extract treated groups exhibited significant reduction in the prostatic index. Oroxylum indicum treated group also exhibited reduced hyperplasia of prostatic epithelium likewise finasteride treated group. Aqueous methanolic extract of Oroxylum indicum significantly inhibited testosterone induced prostate hyperplasia thus indicated the presence of efficient ingredients which can be used for the treatment of BPH.

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“…Finasteride, a commonly used drug for the treatment of BPH, was used as the reference substance (positive control) in this study. It was suspended in distilled water and was administered to rats at a dose of 5 mg/ kg, this is in reference to previous work on BPH [23][24][25]. Aqueous and methanol extracts of M. arboreus were suspended in distilled water and tested at doses of 50, 100, and 200 mg/kg, doses that were extrapolated from previous studies (data not yet published).…”