Aqueous solutions of triblock copolymers used as the media affecting the magnetic relaxation properties of gadolinium ions trapped by metal-oxide nanostructures

Elistratova, Julia; Akhmadeev, Bulat; Korenev, Vladimir S.; Sokolov, Maxim N.; Nizameev, Irek R.; Исмаев, И. Э.; Kadirov, Marsil K.; Sapunova, Аnastasiia S.; Voloshina, Alexandra D.; Amirov, R. R.; Mustafina, Asiya R.

doi:10.1016/j.molliq.2019.111821

Cited by 8 publications

(6 citation statements)

References 43 publications

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“…In addition, it was shown that simpler molybdenum-containing POMs can be used in chemotherapy [115,116]. On the other hand, the initially predicted possibility of the formation of POM conjugates with bioactive substances, drugs, and metal cations using intra-and extrasphere interactions, the possibility of their transport (including iontophoretic) in the body, adds relevance to the studies of POM in the field of targeted drug delivery and diagnostics [117][118][119][120][121][122][123][124][125][126][127][128][129][130][131]. These prospects may relate, inter alia, to immunomodulatory and antiviral agents.…”

Section: Nanocluster Polyoxometalates (Poms)mentioning

confidence: 99%

“…The hydrophobized POMs acquire an ability to more actively interact with molecules of nonpolar substances and adsorb them [110]. There appears a possibility of formation of ionic associates based on POM and cations of metals (alkaline earths, rare earths, transition metals, including luminescent labels and magnetic resonance imaging (MRI) tags [19,[121][122][123]), and of cationic surfactants. Weaker, e.g., hydrogen, bonds also actively participate in the interaction of organic compounds with POMs [182].…”

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

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Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

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Section: Nanocluster Polyoxometalates (Poms)mentioning

confidence: 99%

Section: Association Of Poms With Bioactive Substances and Polymersmentioning

confidence: 99%

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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“…This opens new opportunities in controlling the size of the NPs and their temperature-dependent behavior. The triblock copolymers have been revealed as efficient hydrophilic agents in the synthesis of the nanoparticulate Gd 3+ -based MOFs with high contrasting ability [ 38 ]. However, an impact of their structure and temperature-induced aggregation on controlling of size, aggregation and magnetic relaxation behavior of the MOF-based CAs is not well recognized.…”

Section: Introductionmentioning

confidence: 99%

Molecular and Nano-Structural Optimization of Nanoparticulate Mn2+-Hexarhenium Cluster Complexes for Optimal Balance of High T1- and T2-Weighted Contrast Ability with Low Hemoagglutination and Cytotoxicity

et al. 2022

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The present work introduces rational design of nanoparticulate Mn(II)-based contrast agents through both variation of the μ3 (inner) ligands within a series of hexarhenium cluster complexes [{Re6(μ3-Q)8}(CN)6]4− (Re6Q8, Q = S2−, Se2− or Te2−) and interfacial decoration of the nanoparticles (NPs) K4−2xMnxRe6Q8 (x = 1.3 − 1.8) by a series of pluronics (F-68, P-123, F-127). The results highlight an impact of the ligand and pluronic for the optimal colloid behavior of the NPs allowing high colloid stability in ambient conditions and efficient phase separation under the centrifugation. It has been revealed that the K4−2xMnxRe6Se8 NPs and those decorated by F-127 are optimal from the viewpoint of magnetic relaxivities r1 and r2 (8.9 and 10.9 mM−1s−1, respectively, at 0.47 T) and low hemoagglutination activity. The insignificant leaching of Mn2+ ions from the NPs correlates with their insignificant effect on the cell viability of both M-HeLa and Chang Liver cell lines. The T1- and T2-weighted contrast ability of F-127–K4−2xMnxRe6Q8 NPs was demonstrated through the measurements of phantoms at whole body 1.5 T scanner.

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“…[5,6,20,21] Polyoxometalate (POM) clusters were used as host assemblies for contrast agents. [22,23] We explored [Ln 30 Co 8 Ge 12 W 108 O 408 (OH) 42 (OH 2 ) 30 ] 56À abbreviated as {Ln 30 Co 8 }, these POMs were also studied with Ln2[Gd III , Dy III , Eu III , Y III ]. [24] The main solvent was water as a 10 : 90 H 2 O : D 2 O mix.…”

Section: Introductionmentioning

confidence: 99%

NMR Relaxivities of Paramagnetic, Ultra‐High Spin Heterometallic Clusters within Polyoxometalate Matrix as a Function of Solvent and Metal Ion

et al. 2022

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Selectivity and image contrast are always challenging in magnetic resonance imaging (MRI), which are -inter aliaaddressed by contrast agents. These compounds still need to be improved, and their relaxation properties, i. e., their paramagnetic relaxation enhancement (PRE), needs to be understood. The main goal is to improve specificity and relaxivities, especially at the high magnetic fields currently exploited not only in material science but also in the medical environment. Longitudinal and transverse relaxivities, r 1 and r 2 , which correspond to the longitudinal and transverse relaxation rates R 1 and R 2, normalized to the concentration of the paramagnetic moieties, need to be considered because both contribute to the image contrast. 1 H-relaxivities r 1 and r 2 of high-spin heterometallic clusters were studied containing lanthanide and transition-metal ions within a polyoxometalate matrix. A wide range of magnetic fields from 0.5 T/20 MHz to 33 T/1.4 GHz was applied. The questions addressed here concern the rotational and diffusion correlation times which determine the relaxivities and are affected by the solvent's viscosity. Moreover, the variation of the lanthanide and transition-metal ions of the clusters provided insights into the sensitivity of PRE with respect to the electron spin properties of the paramagnetic centers as well as cooperative effects between lanthanides and transition metal ions.

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Aqueous solutions of triblock copolymers used as the media affecting the magnetic relaxation properties of gadolinium ions trapped by metal-oxide nanostructures

Cited by 8 publications

References 43 publications

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Molecular and Nano-Structural Optimization of Nanoparticulate Mn2+-Hexarhenium Cluster Complexes for Optimal Balance of High T1- and T2-Weighted Contrast Ability with Low Hemoagglutination and Cytotoxicity

NMR Relaxivities of Paramagnetic, Ultra‐High Spin Heterometallic Clusters within Polyoxometalate Matrix as a Function of Solvent and Metal Ion

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