Aqueous Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Decrease During Regression of Rabbit Pupillary Membrane

Yanagawa, Toshihiro; Matsuo, Toshihiko; Matsuo, Nobuhiko

doi:10.1016/s0021-5155(97)00140-8

Japanese Journal of Ophthalmology

1998

DOI: 10.1016/s0021-5155(97)00140-8

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Aqueous Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Decrease During Regression of Rabbit Pupillary Membrane

Toshihiro Yanagawa

Toshihiko Matsuo

Nobuhiko Matsuo

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Cited by 5 publications

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“…These vessels are known to regress during the later stages of ocular development, prenatally in humans and within the first few weeks of postnatal development in rodents. The PMs of newborn rats, which arise from the vessels of the iris stroma and cover the anterior surface of the lens, have been utilized as a model system for studying the mechanism underlying vascular regression during development (15,16,20,28). To date, apoptosis has been implicated in the process of PM regression (15); however, little is known of the mechanism that governs the initiation of apoptosis during this process.…”

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confidence: 99%

Iris movement mediates vascular apoptosis during rat pupillary membrane regression

Morizane

Mohri

Kosaka

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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In the course of mammalian lens development, a transient capillary meshwork known as the pupillary membrane (PM) forms, which is located at the pupil area; the PM nourishes the anterior surface of the lens and then regresses to make the optical path clear. Although the involvement of apoptotic process has been reported in the PM regression, the initiating factor remains unknown. We initially found that regression of the PM coincided with the development of iris motility, and iris movement caused cessation and resumption of blood flow within the PM. Therefore, we investigated whether the development of the iris's ability to constrict and dilate functions as an essential signal that induces apoptosis in the PM. Continuous inhibition of iris movement with mydriatic agents from postnatal day 7 to day 12 suppressed apoptosis of the PM and migration of macrophage toward the PM, and resulted in the persistence of PM in rats. The distribution of apoptotic cells in the regressing PM was diffuse and showed no apparent localization. These results indicated that iris movement induced regression of the PM by changing the blood flow within it. This study suggests the importance of the physiological interactions between tissues-in this case, the iris and the PM-as a signal to advance vascular regression during organ development, and defines a novel function of the iris during ocular development in addition to the well-known function, that is, optimization of light transmission into the eye.

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mentioning

confidence: 99%

Iris movement mediates vascular apoptosis during rat pupillary membrane regression

Morizane

Mohri

Kosaka

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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A small foveal avascular zone may be an historic mark of prematurity

Knight-Nanan²,

et al. 1999

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Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

Lobov

Brooks

Lang

2002

Proc. Natl. Acad. Sci. U.S.A.

609

466

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Modulation of Tie2 receptor activity by its angiopoietin ligands is crucial for angiogenesis, blood vessel maturation, and vascular endothelium integrity. It has been proposed that angiopoietins 1 (Ang1) and 2 (Ang2) are pro-and anti-angiogenic owing to their respective agonist and antagonist signaling action through the Tie2 receptor. The function of Ang2 has remained controversial, however, with recent reports suggesting that in some circumstances, it may be pro-angiogenic. We have examined this issue using the transient ocular microvessel network called the pupillary membrane as a unique in vivo model for studying the effects of vascular regulators. We show that in vivo, in the presence of endogenous vascular endothelial growth factor (VEGF)-A, Ang2 promotes a rapid increase in capillary diameter, remodeling of the basal lamina, proliferation and migration of endothelial cells, and stimulates sprouting of new blood vessels. By contrast, Ang2 promotes endothelial cell death and vessel regression if the activity of endogenous VEGF is inhibited. These observations support a model for regulation of vascularity where VEGF can convert the consequence of Ang2 stimulation from anti-to pro-angiogenic.angiogenesis ͉ pupillary membrane

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Aqueous Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Decrease During Regression of Rabbit Pupillary Membrane

Cited by 5 publications

References 23 publications

Iris movement mediates vascular apoptosis during rat pupillary membrane regression

Iris movement mediates vascular apoptosis during rat pupillary membrane regression

A small foveal avascular zone may be an historic mark of prematurity

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

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