Aqueous Zn2+ analysis: Specific recognition and instant imaging by Schiff base fluorescent probes

He, Hao; Cheng, Zhao; Zheng, Lei

doi:10.1016/j.molstruc.2020.129522

Cited by 21 publications

(10 citation statements)

References 31 publications

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“…The target compounds ( 4a–4i ) were synthesized according to Scheme 2 . In details, reaction of ester 1 with hydrazine hydrate gave hydrazide 2 as described previously [ 57 , 65 ]. Hydrazones 3a – 3d were obtained through acid- catalyzed condensation of 2 with the corresponding aromatic aldehydes [ 66 – 70 ].…”

Section: Methodsmentioning

confidence: 99%

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Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

et al. 2022

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Background Compounds possessing urea/thiourea moiety have a wide range of biological properties including anticancer activity. On the other hand, taking advantage of the low toxicity and structural diversity of hydrazone derivatives, they are presently being considered for designing chemical compounds with hydrazone moiety in the field of cancer treatment. With this in mind, a series of novel ureido/thioureido derivatives possessing a hydrazone moiety bearing nitro and chloro substituents (4a–4i) have been designed, synthesized, characterized and evaluated for their in vitro cytotoxic effect on HT-29 human colon carcinoma and HepG2 hepatocarcinoma cell lines. Results Two compounds (4c and 4e) having the chloro phenylurea group hybridized with phenyl hydrazone bearing nitro or chloro moieties demonstrated potent anticancer effect with the IC50 values between 2.2 and 4.8 µM at 72 h. The mechanism of action of compound 4c was revealed in hepatocellular carcinoma cells as an inducer of apoptosis in a caspase-independent pathway. Conclusion Taken together, the current work presented compound 4c as a potential lead compound in developing future hepatocellular carcinoma chemotherapy drugs. Methods The compounds were synthesized and then characterized by physical and spectral data (FT-IR, 1H-NMR, 13C-NMR, Mass). The anticancer activity was assessed using MTT assay, flowcytometry, annexin-V, DAPI staining and Western blot analysis. Graphical Abstract

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Section: Methodsmentioning

confidence: 99%

“…Each value represents the mean ± SEM of three independent experiments. One-way ANOVA analysis with Tukey post test was performed [57,65]. Hydrazones 3a-3d were obtained through acidcatalyzed condensation of 2 with the corresponding aromatic aldehydes [66][67][68][69][70].…”

Section: Chemistrymentioning

confidence: 99%

Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

et al. 2022

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“…3.4.1 Fluorescence imaging 267,268 . Fluorescence imaging permits monitoring of various processes in cells, tissues, and organelles in real-time via fluorescence microscopy.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Fluorescent Schiff base sensors as a versatile tool for metal ion detection: strategies, mechanistic insights, and applications

Goshisht¹,

2022

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“…It mainly follows the ''turn-on'' and ''turn-off'' mechanisms of fluorescence, so as to realize the detection of fluorescence, and is widely used in various fields due to its advantages of simple operation, high sensitivity, a low detection limit, high selectivity and low cost. [21][22][23][24][25] Some fluorescence sensing compounds, such as metal-organic frameworks (MOFs), 26,27 coumarins, 28,29 rhodamine, 30,31 Schiff-bases, 32,33 and nanoparticles, 34,35 have been widely used in the design of fluorescence probes.…”

Section: Nhmentioning

confidence: 99%

Zinc(ii) Schiff base complexes as dual probes for the detection of NH₄⁺ and HPO₄²⁻ ions

Xiong

et al. 2022

New J. Chem.

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Aqueous Zn2+ analysis: Specific recognition and instant imaging by Schiff base fluorescent probes

Cited by 21 publications

References 31 publications

Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Fluorescent Schiff base sensors as a versatile tool for metal ion detection: strategies, mechanistic insights, and applications

Zinc(ii) Schiff base complexes as dual probes for the detection of NH₄⁺ and HPO₄²⁻ ions

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Aqueous Zn2+ analysis: Specific recognition and instant imaging by Schiff base fluorescent probes

Cited by 21 publications

References 31 publications

Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity

Fluorescent Schiff base sensors as a versatile tool for metal ion detection: strategies, mechanistic insights, and applications

Zinc(ii) Schiff base complexes as dual probes for the detection of NH4+ and HPO42− ions

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Zinc(ii) Schiff base complexes as dual probes for the detection of NH₄⁺ and HPO₄²⁻ ions