Beginning in the 1850s, Christian missionary organizations established schools in Ottoman Palestine. A variety of networks developed over the years, principally those of the Anglicans and Catholics. Initially, these schools provided an education emphasizing European Christian values and subjects. Over time, however, a slow process of indigenization occurred. The first fruits of this process are illustrated by young leaders like Emil Tume and Tewfik Tubi who were prominent in the political opposition in Israel's first years of statehood. Another generation produced such notables as author Raja Shehadeh and Hanan Ashwari. In today's Israel and the Palestinian territories, the best schools, from a standpoint of matriculation, are Christian private schools that are open to all communities. Through this history, the article examines the development of a Christian school network and the political activism, involvement, and empowerment they engendered. It also provides a case study of the Rosary Sisters' school system.