Unified Communications and Collaboration (UCC) is a technology that combines conventional communication with computer technology to provide a more efficient communication platform. During the COVID-19 pandemic, UCC applications, such as Microsoft Team, Zoom Meeting, and Google Meet played major roles to support the teaching and learning process. However, the acceptance of UCC applications and their impacts on the future of teaching and learning process, especially for university students in rural areas, are concerned. Based on this, the current study aims to examine the factors that influence the acceptance of UCC applications at the University in Sumbawa Island, Indonesia using adapted theories of Unified Theory of Acceptance and Use of Technology model (UTAUT). In light, survey questionnaire was distributed online to 210 undergraduate students at the University in Sumbawa Island, Indonesia, to test seven factors, Facilitating Condition (FC), Performance Expectancy (PE), Effort Expectancy (EE), Social Influence (SI), Motivation (MO), Collaboration (CO), and Behavioural Intention (BI) which were analysed using SPSS software. The findings reveal that PE, EE, SI, FC, MO, CO, and BI are significant factors that influence the acceptance of UCC applications. This finding will be a sound reference to improve the use of UCC applications for teaching and learning as well as help universities strategies their future teaching and learning system.