Arabic gum plus colistin coated moxifloxacin-loaded nanoparticles for the treatment of bone infection caused by Escherichia coli

Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

“…Very recently, a similar biofilm-targeting strategy was reported using Arabic gum (AG) to coat MSNs. 741 AG is a branched-chain, complex polysaccharide composed of 1,3-linked beta- d -galactopyranosyl monomers linked to the principal chain through 1,6-linkages [27] whose degradation by secreted bacterial enzymes enhances the retention of MSNs on the biofilm. The nanosystem demonstrated high affinity toward an E. coli biofilm matrix, thanks to the AG shell, and remarkable antibacterial activity due to the combined effect of two antibiotics: moxifloxacin loaded in MSNs, with bactericidal effect, and colistin, entrapped into the AG coating, with disaggregating effect.…”

Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment

“…This branched-chain complex polysaccharide is composed of 1,3-linked beta-Dgalactopyranosyl monomers connected to the main chain through 1,6-linkages, whose degradation by secreted bacterial enzymes improves the retention of MSNs on the biofilm. The nanosystem demonstrated high affinity toward E. coli biofilm matrix, thanks to the Arabic gum coating and, loaded with two clinically relevant antibiotics such as moxifloxacin and colistin, exhibits substantial in vivo efficacy against an osteomyelitis provoked by E. coli [112].…”

“…Once the ability of these MSNs to internalise into the bacteria and the biofilm has been demonstrated, the second challenge in the fight against antimicrobial resistance consists in the design of nanosystems with enhanced antimicrobial efficacy, through the combination of different antimicrobial elements within the same nanoplatform. To this aim, different research groups have reported innovative strategies based in either the co-delivery of antibiotics [112][113][114][115], or the combination of antibiotics plus antimicrobial metal nanoparticles or ions [28].…”

“…Along this line, Meber et al [114] reported the synthesis of core-shell MSNs to simultaneously deliver gentamicin and rifamycin by using a multilayer construction of MSNs, following a step-by-step loading of these antibiotics. In a very recent study, Aguilera-Correa et al [112] described an original methodology to engineer moxifloxacin-loaded MSNs coated with Arabic gum plus colistin to address E.coli bone infections. Significant antibacterial in vitro and in vivo efficacy was observed thanks to the Arabic gum targeting capability towards E. coli biofilm, the disaggregating and antibacterial effect of colistin, and a remarkable antibiofilm action due to the bactericidal activity of moxifloxacin and colistin.…”

Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy

“…Furthermore, engineered and innovative recent formulations based in MSNs are envisioned as new nanoantibiotics for bacterial infection treatment [18]. For example, the combination of different antimicrobial elements within the same nanoplatform, such as the targeted co-delivery of antibiotics [19], or the combination of antibiotics plus multiactive metal ions [20] have been reported as advanced strategies in the fight against antimicrobial resistance. It is also feasible to functionalize MSNs with nanogates that can be opened to deliver antimicrobial cargo upon the application of an external or internal given stimuli, as has been widely reported [21][22][23].…”