Arabidopsis TSPO and porphyrins metabolism

Vanhee, Céline; Batoko, Henri

doi:10.4161/psb.6.9.16477

Cited by 18 publications

(13 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4C). The strong expression of FC, which plays an essential role in heme synthesis, ensures the supply of cofactors for hemoproteins that may be required in response to ALA-and OF-induced photodynamic stress as well as the stress conditions caused by norflurazon (NF), paraquat, wounding, ozone, and drought [24,32,[51][52][53][54]. Transcript levels of HO1 encoding HO, which catalyzes the formation of biliverdin-IXα from heme [55], decreased in ALA-and OF-treated plants, whereas transcript levels of HO2 greatly increased after 2 days of both treatments (Fig.…”

Section: Tablementioning

confidence: 99%

Perturbed porphyrin biosynthesis contributes to differential herbicidal symptoms in photodynamically stressed rice (Oryza sativa) treated with 5-aminolevulinic acid and oxyfluorfen

Phung

Jung

2014

Pesticide Biochemistry and Physiology

View full text Add to dashboard Cite

Section: Tablementioning

confidence: 99%

Perturbed porphyrin biosynthesis contributes to differential herbicidal symptoms in photodynamically stressed rice (Oryza sativa) treated with 5-aminolevulinic acid and oxyfluorfen

Phung

Jung

2014

Pesticide Biochemistry and Physiology

View full text Add to dashboard Cite

“…19 Interestingly, TSPO is reported to play a similar role in regulating the accumulation of porphyrin in mammalian cell lines 95 when challenged with protoporphyrin IX, although recent studies in the TSPO knockout mouse do not confirm this role. 61 In plants, 37,57,96 a role for At TSPO in scavenging of heme and porphyrins is reported, involving degradation of TSPO via an autophagy mechanism. Recent data in mouse also indicate that TSPO is involved in regulating mitochondrial ROS levels and mitophagy, dependent on the ratio of TSPO to VDAC1.…”

Section: Tspo Induction Under Stress Conditions Across Evolutionmentioning

confidence: 99%

Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

et al. 2016

View full text Add to dashboard Cite

Translocator protein 18 kDa (TSPO) was previously known as the peripheral benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the mitochondrial outer membrane. Considerable evidence indicates that it plays regulatory roles in steroidogenesis and apoptosis and is involved in various human diseases, such as metastatic cancer, Alzheimer’s and Parkinson’s disease, inflammation, and anxiety disorders. Ligands of TSPO are widely used as diagnostic tools and treatment options, despite there being no clear understanding of the function of TSPO. An ortholog in the photosynthetic bacterium Rhodobacter was independently discovered as the tryptophan-rich sensory protein (TspO) and found to play a role in the response to changes in oxygen and light conditions that regulate photosynthesis and respiration. As part of this highly conserved protein family found in all three kingdoms, the rat TSPO is able to rescue the knockout phenotype in Rhodobacter, indicating functional as well as structural conservation. Recently, a major breakthrough in the field was achieved: the determination of atomic-resolution structures of TSPO from different species by several independent groups. This now allows us to reexamine the function of TSPO with a molecular perspective. In this review, we focus on recently determined structures of TSPO and their implications for potential functions of this ubiquitous multifaceted protein. We suggest that TSPO is an ancient bacterial receptor/stress sensor that has developed additional interactions, partners, and roles in its mitochondrial outer membrane environment in eukaryotes.

show abstract

“…In an Arabidopsis transgenic cell line over-expressing TSPO, ROS levels were found to be higher than in the wild type. This suggests that the plant TSPO, which is considered a heme scavenger, may mediate ROS homeostasis [ 127 ]. Moreover, TSPO levels are decreased 48 h after abscisic acid (ABA)-induced stress [ 125 ].…”

Section: Plants Tspo and Tetrapyrrolesmentioning

confidence: 99%

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Veenman

Vainshtein

Yasin

et al. 2016

IJMS

View full text Add to dashboard Cite

The 18 kDa translocator protein (TSPO) is highly 0conserved in eukaryotes and prokaryotes. Since its discovery in 1977, numerous studies established the TSPO’s importance for life essential functions. For these studies, synthetic TSPO ligands typically are applied. Tetrapyrroles present endogenous ligands for the TSPO. Tetrapyrroles are also evolutionarily conserved and regulate multiple functions. TSPO and tetrapyrroles regulate each other. In animals TSPO-tetrapyrrole interactions range from effects on embryonic development to metabolism, programmed cell death, response to stress, injury and disease, and even to life span extension. In animals TSPOs are primarily located in mitochondria. In plants TSPOs are also present in plastids, the nuclear fraction, the endoplasmic reticulum, and Golgi stacks. This may contribute to translocation of tetrapyrrole intermediates across organelles’ membranes. As in animals, plant TSPO binds heme and protoporphyrin IX. TSPO-tetrapyrrole interactions in plants appear to relate to development as well as stress conditions, including salt tolerance, abscisic acid-induced stress, reactive oxygen species homeostasis, and finally cell death regulation. In bacteria, TSPO is important for switching from aerobic to anaerobic metabolism, including the regulation of photosynthesis. As in mitochondria, in bacteria TSPO is located in the outer membrane. TSPO-tetrapyrrole interactions may be part of the establishment of the bacterial-eukaryote relationships, i.e., mitochondrial-eukaryote and plastid-plant endosymbiotic relationships.

show abstract

Arabidopsis TSPO and porphyrins metabolism

Cited by 18 publications

References 8 publications

Perturbed porphyrin biosynthesis contributes to differential herbicidal symptoms in photodynamically stressed rice (Oryza sativa) treated with 5-aminolevulinic acid and oxyfluorfen

Perturbed porphyrin biosynthesis contributes to differential herbicidal symptoms in photodynamically stressed rice (Oryza sativa) treated with 5-aminolevulinic acid and oxyfluorfen

Translocator Protein 18 kDa (TSPO): An Old Protein with New Functions?

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

Contact Info

Product

Resources

About