Arabinoxylan as well as β-glucan in barley promotes GLP-1 secretion by increasing short-chain fatty acids production

Mio, Kento; Ogawa, Reina; Tadenuma, Natsuki; Aoe, Seiichiro

doi:10.1016/j.bbrep.2022.101343

Cited by 15 publications

(10 citation statements)

References 31 publications

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“…More and more researchers have found that barley AX has better hypoglycemic and immunomodulatory abilities. To begin with, Kento et al [ 16 ] extracted AX from barley flour and experimentally studied the hypoglycemic ability of AX in mice. They discovered for the first time that AX promotes the secretion of GLP-1, which in turn promotes the secretion of insulin to decrease blood glucose.…”

Section: Biological Activity Of Ax From Various Origin Sourcesmentioning

confidence: 99%

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Recent Developments in Molecular Characterization, Bioactivity, and Application of Arabinoxylans from Different Sources

et al. 2023

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Arabinoxylan (AX) is a polysaccharide composed of arabinose, xylose, and a small number of other carbohydrates. AX comes from a wide range of sources, and its physicochemical properties and physiological functions are closely related to its molecular characterization, such as branched chains, relative molecular masses, and substituents. In addition, AX also has antioxidant, hypoglycemic, antitumor, and proliferative abilities for intestinal probiotic flora, among other biological activities. AXs of various origins have different molecular characterizations in terms of molecular weight, degree of branching, and structure, with varying structures leading to diverse effects of the biological activity of AX. Therefore, this report describes the physical properties, biological activities, and applications of AX in diverse plants, aiming to provide a theoretical basis for future research on AX as well as provide more options for crop breeding.

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Section: Biological Activity Of Ax From Various Origin Sourcesmentioning

confidence: 99%

“…SCFAs may also stimulate the release of the heterotropic hormone glucagon-like protein 1 (GLP-1) via G protein-coupled receptor 43 (Gpr43) in L cells of gastrointestinal endocrine cells. GLP-1 boosts insulin secretion and improves insulin resistance [ 16 ]. Therefore, AX has a hypoglycemic effect because of the increase of GLP-1 in vivo.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Molecular Characterization, Bioactivity, and Application of Arabinoxylans from Different Sources

et al. 2023

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“…Indeed, SCFA stimulate the release of GLP-1 incretin hormones via the G protein-coupled receptor 43 in endocrine cells. GLP-1 promotes insulin secretion [188,189]. In a clinical study, Pino et al showed that β-glucan consumption leads to reduced GLP-1 and insulin production in T2D patients [187].…”

Section: Effects On Glucose Metabolismmentioning

confidence: 99%

“…This effect is associated with the post-prandial response of insulin and serum glucose lowering. Mio et al (2022) observed in their preclinical study an increase in GLP-1 secretion enhanced by SCFA increase linked with barley AX consumption by mice [189]. Lafond et al (2015) described an increase in GLP-1 secretion in overweight women who ate a high-fibre breakfast.…”

Section: Effects On Glucose Metabolismmentioning

confidence: 99%

Functional and Nutritional Characteristics of Natural or Modified Wheat Bran Non-Starch Polysaccharides: A Literature Review

Sztupecki

Rhazi

Dépeint

et al. 2023

Foods

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Wheat bran (WB) consists mainly of different histological cell layers (pericarp, testa, hyaline layer and aleurone). WB contains large quantities of non-starch polysaccharides (NSP), including arabinoxylans (AX) and β-glucans. These dietary fibres have long been studied for their health effects on management and prevention of cardiovascular diseases, cholesterol, obesity, type-2 diabetes, and cancer. NSP benefits depend on their dose and molecular characteristics, including concentration, viscosity, molecular weight, and linked-polyphenols bioavailability. Given the positive health effects of WB, its incorporation in different food products is steadily increasing. However, the rheological, organoleptic and other problems associated with WB integration are numerous. Biological, physical, chemical and combined methods have been developed to optimise and modify NSP molecular characteristics. Most of these techniques aimed to potentially improve food processing, nutritional and health benefits. In this review, the physicochemical, molecular and functional properties of modified and unmodified WB are highlighted and explored. Up-to-date research findings from the clinical trials on mechanisms that WB have and their effects on health markers are critically reviewed. The review points out the lack of research using WB or purified WB fibre components in randomized, controlled clinical trials.

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“…Beta-glucans increase the viscosity of digesta in the intestine, lowering the reuptake of cholesterol and reducing the postprandial concentration of glucose in the blood. The regular consumption of barley contributes to improving the values of serum TC and LDL cholesterol and preventing cardiovascular diseases [7][8][9]. A disease risk health claim was also authorized in the European Union, enabling the marketing of foods (that contain at least 1 g of b-G per quantified portion) with a claim that barley beta-glucans have been shown to lower blood cholesterol, which is a risk factor in the development of coronary heart disease [10].…”

Section: Introductionmentioning

confidence: 99%

Differences in Ratio of Carbon Stable Isotopes among Barley Grain Milling Fractions with Various Concentrations of Beta-Glucans

Levanič,

Cigić,

Germ

et al. 2023

Molecules

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The grains of three barley varieties were milled and sieved to obtain respective milling fractions with a content of beta-glucans (b-G) from 1.4 to 10.7%. The enriched fraction obtained by the extraction and precipitation contained 24.7% of b-G. The differences between the ratio of stable C carbon isotopes were established. Milling fractions with coarse particles had more beta-glucans and a more negative ratio of δ13C isotope in comparison to the respective intact barley grain. However, the enriched fraction had a less negative isotope ratio. So, it is not expected that the deviation from the stable isotope ratio of grain in milling fractions is the result of the content of b-G, but it depends on other barley grain constituents. In different parts of barley grain, there are substances with different stable isotope ratios, and by milling and sieving, they are assorted to the same milling fraction with most of the b-G. The method for determining the ratio of a stable carbon isotope in diverse barley grain fractions, applied in this investigation, is potentially opening the possibility for an additional method of screening the concentration of bioactive constituents in barley grain.

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Arabinoxylan as well as β-glucan in barley promotes GLP-1 secretion by increasing short-chain fatty acids production

Cited by 15 publications

References 31 publications

Recent Developments in Molecular Characterization, Bioactivity, and Application of Arabinoxylans from Different Sources

Recent Developments in Molecular Characterization, Bioactivity, and Application of Arabinoxylans from Different Sources

Functional and Nutritional Characteristics of Natural or Modified Wheat Bran Non-Starch Polysaccharides: A Literature Review

Differences in Ratio of Carbon Stable Isotopes among Barley Grain Milling Fractions with Various Concentrations of Beta-Glucans

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