Arachidonic acid and its COX1/2 metabolites inhibit interferon-γ mediated induction of indoleamine-2,3 dioxygenase in THP-1 cells and Human monocytes

Bassal, Nesrine Kamal; Hughes, B P; Costabile, Maurizio

doi:10.1016/j.plefa.2012.08.001

Cited by 16 publications

(16 citation statements)

References 44 publications

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“…Pretreatment schedule with COX and LOX inhibitors 6 AA and ALX RIN5f cells (20 3 10 3 /100 mL/well) in 96 well plates were treated with 1 mM indomethacin (IM) and 1 mM nordihydroguaiaretic acid (NDGA) 6 10 mg/mL AA for 5 hr. NDGA is a potent inhibitor of LOX enzyme and hence, was used in the present study to know possible involvement of LOX in the actions of AA [37][38][39][40]. At the end of 5 hr of incubation, the cells were treated with 6 mM ALX for 1 hr.…”

Section: Simultaneous Treatment Schedule With Pufa and Alxmentioning

confidence: 99%

Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo

Gundala¹,

Naidu

Das³

2016

BioFactors

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Section: Simultaneous Treatment Schedule With Pufa and Alxmentioning

confidence: 99%

Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo

Gundala¹,

Naidu

Das³

2016

BioFactors

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“…COX-1 is expressed in most tissues and is a constitutive enzyme, whereas COX-2 is mainly present in inammatory cells. 5 There are various signaling pathways involved in the inammation progress, and NF-kB is the central hub molecule for inammation. NF-kB, a nuclear transcription factor, regulates the expression of various genes, including cytokines, iNOS and COX-2, which play critical roles in inammation.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages

Liu

Wang

et al. 2019

RSC Adv.

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“…AA was also shown to maintain an inflammatory state in THP1 and primary monocytes by interfering with the IFN-γ signalling pathway, reducing the phosphorylation of the signal transducer and activator of transcription ( STAT )-1, and ultimately blocking the immunosuppressive activity of indoleamine 2,3-dioxygenase ( IDO ) in vivo [ 118 ].…”

Section: Fatty Acids and Immune Cells: Regulation Of Transcription Factors Inflammatory Pathways And Effector Functionsmentioning

confidence: 99%

Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response

Cornò

Varì

Scazzocchio

et al. 2021

Cells

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Colorectal cancer (CRC) is among the major threatening diseases worldwide, being the third most common cancer, and a leading cause of death, with a global incidence expected to increase in the coming years. Enhanced adiposity, particularly visceral fat, is a major risk factor for the development of several tumours, including CRC, and represents an important indicator of incidence, survival, prognosis, recurrence rates, and response to therapy. The obesity-associated low-grade chronic inflammation is thought to be a key determinant in CRC development, with the adipocytes and the adipose tissue (AT) playing a significant role in the integration of diet-related endocrine, metabolic, and inflammatory signals. Furthermore, AT infiltrating immune cells contribute to local and systemic inflammation by affecting immune and cancer cell functions through the release of soluble mediators. Among the factors introduced with diet and enriched in AT, fatty acids (FA) represent major players in inflammation and are able to deeply regulate AT homeostasis and immune cell function through gene expression regulation and by modulating the activity of several transcription factors (TF). This review summarizes human studies on the effects of dietary FA on AT homeostasis and immune cell functions, highlighting the molecular pathways and TF involved. The relevance of FA balance in linking diet, AT inflammation, and CRC is also discussed. Original and review articles were searched in PubMed without temporal limitation up to March 2021, by using fatty acid as a keyword in combination with diet, obesity, colorectal cancer, inflammation, adipose tissue, immune cells, and transcription factors.

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Arachidonic acid and its COX1/2 metabolites inhibit interferon-γ mediated induction of indoleamine-2,3 dioxygenase in THP-1 cells and Human monocytes

Cited by 16 publications

References 44 publications

Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo

Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo

Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages

Dietary Fatty Acids at the Crossroad between Obesity and Colorectal Cancer: Fine Regulators of Adipose Tissue Homeostasis and Immune Response

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